Mayo Center for Cell Signaling in Gastroenterology

梅奥胃肠病学细胞信号转导中心

• 批准号: 7908858
• 负责人: Nicholas F. LaRusso
• 金额: $ 113.33万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908858
• 关键词: Mayo; Center; Cell; Signaling; Gastroenterology

The long-term objective of the Mayo Center for Cell Signaling in Gastroenterology (MCCSG) is to understand the signaling pathways that control the function of gastrointestinal cells in health and disease. The Center members are organized into three Mechanistic Research Theme interest groups: i.) signal transduction; ii.) membrane receptors and ion channels; and, iii.) genetics and gene regulation. Each Mechanistic Research Theme represents an important area of signaling research that is an area of tremendous strength at Mayo Clinic. Our global hypothesis is that rapid advances in clinical care for patients with digestive diseases requires strong support of basic science research to identify disease mechanisms and intermediate biomarkers for digestive diseases, and that these basic science discoveries will generate translational research opportunities resulting in clinical trials. The Center goals are to promote and enhance cell signaling research by: i.) fostering collaborative, multidisciplinary research both by expanding the technical and collaborative capabilities of established Gl scientists and by attracting investigators from other disciplines; ii.) developing and implementing a robust and diverse Scientific Enrichment Program that includes seminars, workshops, symposia, a visiting faculty program, mini-sabbaticals, and web-based curricula; iii.) identifying and nurturing development of new Gl investigators via a rigorously peer-reviewed, widely publicized Pilot and Feasibility Program; and, iv.) promoting synergistic interaction between the signaling research base and the clinical research expertise of Mayo Gl investigators through activities that support signaling-related research and promote translation of basic science discoveries into clinical research. The Center seeks to support the three Mechanistic Research Themes by creating a supportive infrastructure that makes technologies more easily accessible, provides technical expertise to members from experts in a particular technology, uses existing resources efficiently, and develops novel methodologies through three linked biomedical Center Cores. The proposed biomedical cores are the: i.) Clinical Core; ii.) Genetics Core; and, iii.) Optical Microscopy Core. These Cores were developed by Center leadership in response to detailed and thoughtful analysis of barriers to cell signaling research and Center member surveys. The Core's specific goals are to: i.) develop and/or exploit advanced methods in biospecimen acquisition, processing, and annotation to enhance biospecimen collection and accessibility for Center investigators; ii.) enhance Center member's access to and implementation of current and emerging key genetic technologies; and, iii.) provide Center members with reliable access to state-of-the-art microscopic technology and expertise that will facilitate investigations of the pathogenesis of gastrointestinal and liver diseases.

马约胃肠病学细胞信号传导中心（MCCSG）的长期目标是了解控制健康和疾病中胃肠细胞功能的信号传导途径。该中心的成员被组织成三个机械研究主题兴趣小组：i。信号转导; ii.）膜受体和离子通道;和，iii.）遗传学和基因调控。每个机制研究主题代表了信号研究的一个重要领域，这是马约诊所的一个巨大优势领域。我们的全球假设是，消化系统疾病患者临床护理的快速发展需要基础科学研究的大力支持，以确定消化系统疾病的疾病机制和中间生物标志物，并且这些基础科学发现将产生转化研究机会，从而导致临床试验。该中心的目标是通过以下方式促进和加强细胞信号传导研究：i.通过扩大既定GI科学家的技术和协作能力以及吸引其他学科的研究人员来促进协作性、多学科研究; ii.）制定和实施一个强大而多样化的科学充实计划，包括研讨会、讲习班、专题讨论会、客座教师计划、迷你休假和基于网络的课程; iii.）通过严格的同行评审、广泛宣传的试点和可行性计划，确定和培养新的全球投资研究人员;以及iv.）通过支持信号相关研究和促进基础科学发现转化为临床研究的活动，促进信号研究基地与马约GI研究者的临床研究专业知识之间的协同互动。该中心旨在通过创建一个支持性的基础设施，使技术更容易获得，提供技术专业知识，以支持三个机械研究主题，从专家在特定技术的成员，有效地利用现有资源，并通过三个相互关联的生物医学中心核心开发新的方法。建议的生物医学核心是：i.）临床核心; ii.）遗传学核心;和，iii.）光学显微镜核心。这些核心是由中心领导层开发的，以响应对细胞信号研究障碍的详细和周到的分析以及中心成员的调查。核心的具体目标是：开发和/或利用生物样本采集、处理和注释方面的先进方法，以增强生物样本采集和中心研究者的可访问性; ii.）加强中心成员对现有和新兴关键遗传技术的获取和实施; iii.）为中心成员提供可靠的最先进的显微技术和专业知识，这将有助于研究胃肠道和肝脏疾病的发病机制。