Mayo Center for Cell Signaling in Gastroenterology

马约胃肠病学细胞信号中心（C-SiG）的目标是将发现， 翻译和以患者为导向的研究人员，以加强理解和治疗利用 胃肠细胞中的信号通路，以改善消化系统疾病患者的健康。的 研究基地由59名科学家和2300万美元（直接成本，70%的增长）在消化系统疾病相关 经费C-SiG成员被组织成三个机械研究主题：1）离子 通道/膜受体; ii）信号转导;和iii）遗传学和基因调控。我们 中心假设是，消化系统疾病患者的临床护理的进步需要一个 促进基础设施，支持多学科科学家之间有意义的互动， 细胞机制，途径和治疗目标，以促进基本发现的快速转化， 临床试验C-SiG的总体具体目标是：i）通过扩大 技术和协作能力，并吸引来自其他国家的研究人员 （i）制定和实施一个强有力的科学充实方案，包括研讨会， 讲习班，研讨会，访问教师计划，迷你休假，和基于网络的课程; iii）提供 专门的设备、技术、方法、试剂和专业知识，以协助C-SiG成员 通过C-SiG核心，包括：a）最先进的显微技术和咨询专业知识 （光学显微镜核心）; B）加速和扩展的生物样本采集、处理，以及 c）新兴的遗传技术和模型系统（遗传学和模型系统） 系统核心）; iv）通过同行评审的试点和可行性确定和培养新的GI研究人员 v）促进C-SiG成员与马约其他GI研究人员之间的协同互动 以及在其他GI中心，以促进由鉴定细胞治疗剂产生的临床试验。 目标; vi）与马约的其他NIDDK中心分享技术（例如，PKD中心）和现有消化系统 疾病研究核心中心，特别是在中西部（即。中西部DDRCC联盟）。

The goal of the Mayo Clinic Center for Cell Signaling in Gastroenterology (C-SiG) is to connect discovery, translational, and patient-oriented investigators to enhance understanding and therapeutically exploit signaling pathways in gastrointestinal cells to improve the health of patients with digestive diseases. The Research Base consists of 59 scientists and $23 million (direct costs, 70% growth) in digestive disease-related funding. C-SiG members are organized into three Mechanistic Research Themes: 1) Ion channels/membrane receptors; ii) Signal transduction; and, iii) Genetics and gene regulation. Our CENTRAL HYPOTHESIS is that advances in clinical care of patients with digestive diseases requires a facilitative infrastructure supporting meaningful interactions among multidisciplinary scientists investigating cellular mechanisms, pathways and therapeutic targets to enhance rapid translation of basic discoveries into clinical trials. C-SiG's OVERALL SPECIFIC AIMS are to: i) Foster multidisciplinary research by expanding technical and collaborative capabilities of established Gl scientists and attracting investigators from other disciplines; li) Develop and implement a robust Scientific Enrichment Program that includes seminars, workshops, symposia, a visiting faculty program, mini-sabbatical, and Web-based curricula; iii) Offer specialized equipment, technologies, methodologies, reagents, and expertise to assist C-SiG members through the C-SiG Cores, including: a) State-of-the-art microscopic technology and consultative expertise (Optical Microscopy Core); b) Accelerated and expanded biospecimen acquisition, processing, and annotation (Clinical Core); c) Emerging genetic technologies and model systems (Genetics and Model Systems Core); iv) Identify and nurture new GI investigators via a peer-reviewed Pilot and Feasibility Program; v) Promote synergistic interactions between C-SiG members and other Gl investigators at Mayo and at other Gl centers to facilitate clinical trials resulting from the identification of cellular therapeutic targets; vi) Share technologies with other NIDDK centers at Mayo (e.g., PKD Center) and existing Digestive Disease Research Core Centers, especially in the Midwest (i.e.. Midwest DDRCC Alliance).