Mayo Center for Cell Signaling in Gastroenterology

梅奥胃肠病学细胞信号转导中心

• 批准号: 8903714
• 负责人: Nicholas F. LaRusso
• 金额: $ 119.25万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8903714
• 关键词: Archives; Biological Models; Cells; Center for Translational Science Activities; Clinic; Clinical; Clinical Trials; Comprehensive Cancer Center; Diagnosis; Digestive System Disorders; Direct Costs; Discipline; Disease; Educational Curriculum; Educational workshop; Enteral; Equipment; Extramural Activities; Faculty; Focus Groups; Fostering; Funding; Gastroenterology; Gastrointestinal Diseases; Gene Expression Regulation; Genetic; Genetic Models; Germ-Free; Goals; Grant; Growth; Health; Inflammation; Instruction; Interdisciplinary Study; Ion Channel; Lead; Liver; Membrane; Methodology; Microscopic; Microscopy; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Neurosciences; Online Systems; Optics; Pathway interactions; Patients; Peer Review; Plasmids; Polycystic Kidney Diseases; Population Sciences; Prevention; Process; Productivity; Public Health; Reagent; Research; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Scientist; Signal Pathway; Signal Transduction; Techniques; Technology; Training; Translations; United States National Institutes of Health; Visit; animal facility; base; cell transformation; cellular imaging; clinical care; cost; cost effective; gastrointestinal; genetic technology; health care service utilization; human disease; improved; individualized medicine; member; microbiome; model development; multidisciplinary; patient oriented; patient population; practical application; programs; receptor; symposium; therapeutic target

The goal of the Mayo Clinic Center for Cell Signaling in Gastroenterology (C-SiG) is to connect discovery, translational, and patient-oriented investigators to enhance understanding and therapeutically exploit signaling pathways in gastrointestinal cells to improve the health of patients with digestive diseases. The Research Base consists of 59 scientists and $23 million (direct costs, 70% growth) in digestive disease-related funding. C-SiG members are organized into three Mechanistic Research Themes: 1) Ion channels/membrane receptors; ii) Signal transduction; and, iii) Genetics and gene regulation. Our CENTRAL HYPOTHESIS is that advances in clinical care of patients with digestive diseases requires a facilitative infrastructure supporting meaningful interactions among multidisciplinary scientists investigating cellular mechanisms, pathways and therapeutic targets to enhance rapid translation of basic discoveries into clinical trials. C-SiG's OVERALL SPECIFIC AIMS are to: i) Foster multidisciplinary research by expanding technical and collaborative capabilities of established Gl scientists and attracting investigators from other disciplines; li) Develop and implement a robust Scientific Enrichment Program that includes seminars, workshops, symposia, a visiting faculty program, mini-sabbatical, and Web-based curricula; iii) Offer specialized equipment, technologies, methodologies, reagents, and expertise to assist C-SiG members through the C-SiG Cores, including: a) State-of-the-art microscopic technology and consultative expertise (Optical Microscopy Core); b) Accelerated and expanded biospecimen acquisition, processing, and annotation (Clinical Core); c) Emerging genetic technologies and model systems (Genetics and Model Systems Core); iv) Identify and nurture new GI investigators via a peer-reviewed Pilot and Feasibility Program; v) Promote synergistic interactions between C-SiG members and other Gl investigators at Mayo and at other Gl centers to facilitate clinical trials resulting from the identification of cellular therapeutic targets; vi) Share technologies with other NIDDK centers at Mayo (e.g., PKD Center) and existing Digestive Disease Research Core Centers, especially in the Midwest (i.e.. Midwest DDRCC Alliance).

梅奥临床胃肠病学细胞信号中心(C-SIG)的目标是将发现， 翻译的，以病人为导向的研究人员，以增进理解和治疗开发 胃肠道细胞中的信号通路以改善消化系统疾病患者的健康。这个 研究基地由59名科学家和2300万美元(直接成本，70%增长)的消化系统疾病相关人员组成 资金问题。C-SIG成员被组织成三个力学研究主题：1)离子 通道/膜受体；ii)信号转导；以及iii)遗传学和基因调控。我们的 中心假设是，消化系统疾病患者的临床护理的进步需要 促进基础设施，支持多学科科学家之间有意义的互动 细胞机制、途径和治疗靶点以促进基本发现快速转化为 临床试验。C-SIG的总体具体目标是：i)通过扩大规模促进多学科研究 现有全球科学家的技术和协作能力，并吸引来自其他国家的研究人员 学科；li)制定和实施强有力的科学丰富计划，其中包括研讨会， 研讨会、座谈会、访问教员计划、迷你休假和基于网络的课程；iii)提供 协助C-SIG成员的专门设备、技术、方法、试剂和专业知识 通过C-Sig核心，包括：a)最先进的微观技术和咨询专门知识 (光学显微镜核心)；b)加速和扩大生物显微镜的获取、处理和 注解(临床核心)；c)新兴基因技术和模型系统(遗传学和模型 系统核心)；四)通过同行评审的试点和可行性确定和培养新的GI调查员 方案；v)促进C-Sig成员与Mayo的其他Gl调查员之间的协同互动 和其他G1中心，以促进通过鉴定细胞疗法而产生的临床试验 目标；vi)与设在Mayo的其他NIDDK中心(例如，PKD中心)和现有的消化系统共享技术 疾病研究核心中心，特别是在中西部(即中西部DDRCC联盟)。