Mayo Center for Cell Signaling in Gastroenterology

梅奥胃肠病学细胞信号转导中心

• 批准号: 8309305
• 负责人: Nicholas F. LaRusso
• 金额: $ 113.33万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8309305
• 关键词: Affect; Area; Basic Science; Biological Markers; Cells; Clinic; Clinical; Clinical Research; Clinical Trials; Collection; Development; Digestive System Disorders; Discipline; Disease; Educational Curriculum; Educational workshop; Faculty; Fostering; Gastroenterology; Gastrointestinal Diseases; Gene Expression Regulation; Genetic; Goals; Grant; Health; Interdisciplinary Study; Interest Group; Investigation; Ion Channel; Leadership; Link; Liver diseases; Membrane; Methodology; Methods; Microscopic; Microscopy; Online Systems; Optics; Pathogenesis; Patient Care; Patients; Peer Review; Process; Public Health; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Scientist; Signal Pathway; Signal Transduction; Surveys; Technical Expertise; Technology; Translational Research; Translations; Visit; base; clinical care; cost; gastrointestinal function; genetic technology; health care service utilization; improved; member; novel; programs; receptor; response; symposium

The long-term objective of the Mayo Center for Cell Signaling in Gastroenterology (MCCSG) is to understand the signaling pathways that control the function of gastrointestinal cells in health and disease. The Center members are organized into three Mechanistic Research Theme interest groups: i.) signal transduction; ii.) membrane receptors and ion channels; and, iii.) genetics and gene regulation. Each Mechanistic Research Theme represents an important area of signaling research that is an area of tremendous strength at Mayo Clinic. Our global hypothesis is that rapid advances in clinical care for patients with digestive diseases requires strong support of basic science research to identify disease mechanisms and intermediate biomarkers for digestive diseases, and that these basic science discoveries will generate translational research opportunities resulting in clinical trials. The Center goals are to promote and enhance cell signaling research by: i.) fostering collaborative, multidisciplinary research both by expanding the technical and collaborative capabilities of established Gl scientists and by attracting investigators from other disciplines; ii.) developing and implementing a robust and diverse Scientific Enrichment Program that includes seminars, workshops, symposia, a visiting faculty program, mini-sabbaticals, and web-based curricula; iii.) identifying and nurturing development of new Gl investigators via a rigorously peer-reviewed, widely publicized Pilot and Feasibility Program; and, iv.) promoting synergistic interaction between the signaling research base and the clinical research expertise of Mayo Gl investigators through activities that support signaling-related research and promote translation of basic science discoveries into clinical research. The Center seeks to support the three Mechanistic Research Themes by creating a supportive infrastructure that makes technologies more easily accessible, provides technical expertise to members from experts in a particular technology, uses existing resources efficiently, and develops novel methodologies through three linked biomedical Center Cores. The proposed biomedical cores are the: i.) Clinical Core; ii.) Genetics Core; and, iii.) Optical Microscopy Core. These Cores were developed by Center leadership in response to detailed and thoughtful analysis of barriers to cell signaling research and Center member surveys. The Core's specific goals are to: i.) develop and/or exploit advanced methods in biospecimen acquisition, processing, and annotation to enhance biospecimen collection and accessibility for Center investigators; ii.) enhance Center member's access to and implementation of current and emerging key genetic technologies; and, iii.) provide Center members with reliable access to state-of-the-art microscopic technology and expertise that will facilitate investigations of the pathogenesis of gastrointestinal and liver diseases.

梅奥胃肠病细胞信号中心(MCCSG)的长期目标是了解在健康和疾病中控制胃肠道细胞功能的信号通路。中心成员被组织成三个力学研究主题兴趣小组：i)信号转导；ii.)膜受体和离子通道；以及遗传学和基因调控。每个机械学研究主题都代表了信号研究的一个重要领域，这是梅奥诊所非常有实力的领域。我们的全球假设是，消化疾病患者临床护理的快速进步需要基础科学研究的大力支持，以确定消化系统疾病的发病机制和中间生物标志物，并且这些基础科学发现将产生转化研究机会，从而导致临床试验。该中心的目标是通过以下方式促进和加强细胞信号研究：i)通过扩大全球实验室现有科学家的技术和协作能力，以及通过吸引其他学科的研究人员，促进协作、多学科研究；2)制定和实施强有力和多样化的科学丰富计划，其中包括研讨会、研讨会、座谈会、访问教员计划、迷你休假和基于网络的课程；通过严格的同行评审、广泛宣传的试点和可行性计划，确定和培育新的全球调查人员的发展；以及，iv)通过支持信号相关研究并促进基础科学发现转化为临床研究的活动，促进信号研究基地与Mayo Gl研究人员的临床研究专业知识之间的协同互动。该中心寻求通过创建一个支持性基础设施来支持三个机械研究主题，使技术更容易获得，向成员提供特定技术专家的技术专长，有效利用现有资源，并通过三个相互关联的生物医学中心核心开发新的方法。建议的生物医学核心是：i.)临床核心；ii.)遗传学核心；以及，iii.)光学显微镜核心。这些核心是由中心领导层在对细胞信号研究和中心成员调查的障碍进行详细和深思熟虑的分析后开发的。核心的具体目标是：i.)开发和/或利用生物标本采集、处理和注释方面的先进方法，以加强生物标本的收集和中心调查人员的可及性；2)促进中心成员获得和实施当前和新兴的关键基因技术；以及为中心成员提供可靠的获取最先进的显微技术和专业知识的途径，这些技术和专业知识将有助于研究胃肠道和肝脏疾病的发病机制。