Mayo Center for Cell Signaling in Gastroenterology

梅奥胃肠病学细胞信号中心（MCCSG）的长期目标是了解控制胃肠细胞在健康和疾病中的功能的信号通路。中心成员分为三个机械研究主题兴趣小组：1)信号转导；Ii)膜受体和离子通道；3)遗传学和基因调控。每个机制研究主题代表了信号研究的一个重要领域，这是梅奥诊所的一个巨大力量领域。我们的总体假设是，消化系统疾病患者临床护理的快速发展需要基础科学研究的有力支持，以确定消化系统疾病的疾病机制和中间生物标志物，这些基础科学发现将产生转化研究机会，从而导致临床试验。中心的目标是通过以下方式促进和加强细胞信号研究：1)通过扩大已有的Gl科学家的技术和协作能力以及吸引其他学科的研究人员来促进多学科合作研究；ii.)制定和实施一个强有力的、多样化的科学充实计划，包括研讨会、讲习班、专题讨论会、访问教师计划、小型休假和网络课程；iii)通过严格的同行评审、广泛宣传的试点和可行性计划，确定和培养新的Gl研究人员；iv)通过支持信号相关研究和促进基础科学发现转化为临床研究的活动，促进信号研究基地与Mayo Gl研究人员临床研究专业知识之间的协同互动。该中心寻求通过创建支持性基础设施来支持三个机械研究主题，使技术更容易获得，为特定技术专家的成员提供技术专业知识，有效利用现有资源，并通过三个相互关联的生物医学中心核心开发新方法。提出的生物医学核心是：1。临床核心;二)。遗传学的核心;第三,)。光学显微镜核心。这些核心是由中心领导层根据对细胞信号研究障碍的详细和深思熟虑的分析和中心成员调查而开发的。核心的具体目标是：i.)开发和/或利用生物标本采集、处理和注释的先进方法，以增强中心研究人员的生物标本收集和可及性；ii)加强中心成员对当前和新兴关键遗传技术的获取和实施；iii)为中心成员提供可靠的途径，使其能够接触到最先进的显微技术和专业知识，这将有助于研究胃肠道和肝脏疾病的发病机制。

The long-term objective of the Mayo Center for Cell Signaling in Gastroenterology (MCCSG) is to understand the signaling pathways that control the function of gastrointestinal cells in health and disease. The Center members are organized into three Mechanistic Research Theme interest groups: i.) signal transduction; ii.) membrane receptors and ion channels; and, iii.) genetics and gene regulation. Each Mechanistic Research Theme represents an important area of signaling research that is an area of tremendous strength at Mayo Clinic. Our global hypothesis is that rapid advances in clinical care for patients with digestive diseases requires strong support of basic science research to identify disease mechanisms and intermediate biomarkers for digestive diseases, and that these basic science discoveries will generate translational research opportunities resulting in clinical trials. The Center goals are to promote and enhance cell signaling research by: i.) fostering collaborative, multidisciplinary research both by expanding the technical and collaborative capabilities of established Gl scientists and by attracting investigators from other disciplines; ii.) developing and implementing a robust and diverse Scientific Enrichment Program that includes seminars, workshops, symposia, a visiting faculty program, mini-sabbaticals, and web-based curricula; iii.) identifying and nurturing development of new Gl investigators via a rigorously peer-reviewed, widely publicized Pilot and Feasibility Program; and, iv.) promoting synergistic interaction between the signaling research base and the clinical research expertise of Mayo Gl investigators through activities that support signaling-related research and promote translation of basic science discoveries into clinical research. The Center seeks to support the three Mechanistic Research Themes by creating a supportive infrastructure that makes technologies more easily accessible, provides technical expertise to members from experts in a particular technology, uses existing resources efficiently, and develops novel methodologies through three linked biomedical Center Cores. The proposed biomedical cores are the: i.) Clinical Core; ii.) Genetics Core; and, iii.) Optical Microscopy Core. These Cores were developed by Center leadership in response to detailed and thoughtful analysis of barriers to cell signaling research and Center member surveys. The Core's specific goals are to: i.) develop and/or exploit advanced methods in biospecimen acquisition, processing, and annotation to enhance biospecimen collection and accessibility for Center investigators; ii.) enhance Center member's access to and implementation of current and emerging key genetic technologies; and, iii.) provide Center members with reliable access to state-of-the-art microscopic technology and expertise that will facilitate investigations of the pathogenesis of gastrointestinal and liver diseases.