Mayo Center for Cell Signaling in Gastroenterology

梅奥胃肠病学细胞信号转导中心

• 批准号: 8699451
• 负责人: Nicholas F. LaRusso
• 金额: $ 119.25万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8699451
• 关键词: Biological Models; Cells; Clinic; Clinical; Clinical Trials; Diagnosis; Digestive System Disorders; Direct Costs; Discipline; Educational Curriculum; Educational workshop; Equipment; Faculty; Fostering; Funding; Gastroenterology; Gastrointestinal Diseases; Gene Expression Regulation; Genetic; Genetic Models; Goals; Grant; Growth; Health; Interdisciplinary Study; Ion Channel; Lead; Membrane; Methodology; Microscopic; Microscopy; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Online Systems; Optics; Pathway interactions; Patients; Peer Review; Prevention; Process; Public Health; Reagent; Research; Research Infrastructure; Research Personnel; Research Support; Scientist; Signal Pathway; Signal Transduction; Technology; Therapeutic; Translations; Visit; base; clinical care; cost; gastrointestinal; genetic technology; health care service utilization; human disease; improved; member; multidisciplinary; patient oriented; practical application; programs; public health relevance; receptor; symposium; therapeutic target

DESCRIPTION, OVERALL (provided by applicant): The goal of the Mayo Clinic Center for Cell Signaling in Gastroenterology (C-SiG) is to connect discovery, translational, and patient-oriented investigators to enhance understanding and therapeutically exploit signaling pathways in gastrointestinal cells to improve the health of patients with digestive diseases. The Research Base consists of 59 scientists and $23 million (direct costs, 70% growth) in digestive disease related funding. C-SiG members are organized into three Mechanistic Research Themes: 1) Ion channels/membrane receptors; ii) Signal transduction; and, iii) Genetics and gene regulation. Our CENTRAL HYPOTHESIS is that advances in clinical care of patients with digestive diseases requires a facilitative infrastructure supporting meaningful interactions among multidisciplinary scientists investigating cellular mechanisms, pathways and therapeutic targets to enhance rapid translation of basic discoveries into clinical trials. C-SiG's OVERALL SPECIFIC AIMS are to: i) Foster multidisciplinary research by expanding technical and collaborative capabilities of established Gl scientists and attracting investigators from other disciplines; li) Develop and implement a robust Scientific Enrichment Program that includes seminars, workshops, symposia, a visiting faculty program, minisabbatical, and Web-based curricula; iii) Offer specialized equipment, technologies, methodologies, reagents, and expertise to assist C-SiG members through the C-SiG Cores, including: a) State-of-the-art microscopic technology and consultative expertise (Optical Microscopy Core); b) Accelerated and expanded biospecimen acquisition, processing, and annotation (Clinical Core); c) Emerging genetic technologies and model systems (Genetics and Model Systems Core); iv) Identify and nurture new Gl investigators via a peer-reviewed Pilot and Feasibility Program; v) Promote synergistic interactions between C-SiG members and other Gl investigators at Mayo and at other Gl centers to facilitate clinical trials resulting from the identification of cellular therapeutic tarets; vi) Share technologies with other NIDDK centers at Mayo (e.g., PKD Center) and existing Digestive Disease Research Core Centers, especially in the Midwest (i.e. Midwest DDRCC Alliance).

描述，总体（由申请人提供）：胃肠病学（C-SIG）中蛋黄酱诊所信号转导的目标是连接发现，转化和以患者为导向的研究者，以增强理解和治疗利用胃肠道细胞中的信号通路，以改善患有消化性疾病患者的健康状况。研究基础包括59位科学家和2300万美元（直接成本，增长70％）与消化疾病有关的资金组成。 C-SIG成员分为三个机械研究主题：1）离子通道/膜受体； ii）信号转导； iii）遗传学和基因调节。我们的中心假设是，消化疾病患者的临床护理进展需要促进基础设施，以支持多学科科学家之间有意义的相互作用，研究了细胞机制，途径和治疗靶标，以将基本发现的快速转化为临床试验。 C-SIG的总体具体目的是：i）通过扩大已建立GL科学家的技术和协作能力来培养多学科研究，并吸引其他学科的研究人员； li）制定并实施一个强大的科学丰富计划，其中包括研讨会，研讨会，研讨会，访问教师计划，MiniSablation和基于Web的课程； iii）提供专业设备，技术，方法，试剂和专业知识，以通过C-SIG核心为C-SIG成员提供帮助，包括：a）最先进的显微镜技术和咨询专业知识（光学显微镜核心）； b）加速和扩大生物素的获取，加工和注释（临床核心）； c）新兴的遗传技术和模型系统（遗传学和模型系统核心）； iv）通过同行评审的飞行员和可行性计划来识别和培养新的GL研究人员； v）促进梅奥和其他GL中心的C-SIG成员与其他GL研究者之间的协同相互作用，以促进鉴定细胞治疗焦油的临床试验； vi）与Mayo（例如PKD中心）和现有的消化疾病研究核心中心的其他NIDDK中心共享技术，尤其是在中西部（即中西部DDRCC联盟）。