Mayo Center for Cell Signaling in Gastroenterology

梅奥胃肠病学细胞信号转导中心

• 批准号: 8699451
• 负责人: Nicholas F. LaRusso
• 金额: $ 119.25万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8699451
• 关键词: Biological Models; Cells; Clinic; Clinical; Clinical Trials; Diagnosis; Digestive System Disorders; Direct Costs; Discipline; Educational Curriculum; Educational workshop; Equipment; Faculty; Fostering; Funding; Gastroenterology; Gastrointestinal Diseases; Gene Expression Regulation; Genetic; Genetic Models; Goals; Grant; Growth; Health; Interdisciplinary Study; Ion Channel; Lead; Membrane; Methodology; Microscopic; Microscopy; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Online Systems; Optics; Pathway interactions; Patients; Peer Review; Prevention; Process; Public Health; Reagent; Research; Research Infrastructure; Research Personnel; Research Support; Scientist; Signal Pathway; Signal Transduction; Technology; Therapeutic; Translations; Visit; base; clinical care; cost; gastrointestinal; genetic technology; health care service utilization; human disease; improved; member; multidisciplinary; patient oriented; practical application; programs; public health relevance; receptor; symposium; therapeutic target

DESCRIPTION, OVERALL (provided by applicant): The goal of the Mayo Clinic Center for Cell Signaling in Gastroenterology (C-SiG) is to connect discovery, translational, and patient-oriented investigators to enhance understanding and therapeutically exploit signaling pathways in gastrointestinal cells to improve the health of patients with digestive diseases. The Research Base consists of 59 scientists and $23 million (direct costs, 70% growth) in digestive disease related funding. C-SiG members are organized into three Mechanistic Research Themes: 1) Ion channels/membrane receptors; ii) Signal transduction; and, iii) Genetics and gene regulation. Our CENTRAL HYPOTHESIS is that advances in clinical care of patients with digestive diseases requires a facilitative infrastructure supporting meaningful interactions among multidisciplinary scientists investigating cellular mechanisms, pathways and therapeutic targets to enhance rapid translation of basic discoveries into clinical trials. C-SiG's OVERALL SPECIFIC AIMS are to: i) Foster multidisciplinary research by expanding technical and collaborative capabilities of established Gl scientists and attracting investigators from other disciplines; li) Develop and implement a robust Scientific Enrichment Program that includes seminars, workshops, symposia, a visiting faculty program, minisabbatical, and Web-based curricula; iii) Offer specialized equipment, technologies, methodologies, reagents, and expertise to assist C-SiG members through the C-SiG Cores, including: a) State-of-the-art microscopic technology and consultative expertise (Optical Microscopy Core); b) Accelerated and expanded biospecimen acquisition, processing, and annotation (Clinical Core); c) Emerging genetic technologies and model systems (Genetics and Model Systems Core); iv) Identify and nurture new Gl investigators via a peer-reviewed Pilot and Feasibility Program; v) Promote synergistic interactions between C-SiG members and other Gl investigators at Mayo and at other Gl centers to facilitate clinical trials resulting from the identification of cellular therapeutic tarets; vi) Share technologies with other NIDDK centers at Mayo (e.g., PKD Center) and existing Digestive Disease Research Core Centers, especially in the Midwest (i.e. Midwest DDRCC Alliance).

总体描述（由申请人提供）：马约胃肠病学细胞信号传导临床中心（C-SiG）的目标是将发现、转化和以患者为导向的研究者联系起来，以增强对胃肠细胞中信号传导通路的理解并在治疗上加以利用，从而改善消化系统疾病患者的健康。该研究基地由59名科学家和2300万美元（直接成本，增长70%）的消化系统疾病相关资金组成。C-SiG成员分为三个机制研究主题：1）离子通道/膜受体; ii）信号转导; iii）遗传学和基因调控。我们的中心假设是，消化系统疾病患者临床护理的进步需要一个促进性的基础设施，支持多学科科学家之间有意义的互动，研究细胞机制，途径和治疗靶点，以促进基本发现快速转化为临床试验。C-SiG的总体具体目标是：i）通过扩大知名GI科学家的技术和协作能力并吸引其他学科的研究人员来促进多学科研究; li）开发和实施一个强大的科学充实计划，包括研讨会、讲习班、专题讨论会、客座教师计划、迷你实习和基于网络的课程; iii）提供专门的设备、技术、方法、试剂和专业知识，通过C-SiG核心协助C-SiG成员，包括：（光学显微镜核心）; B）加速和扩展的生物样本采集、处理和注释（c）新兴遗传技术和模型系统iv）通过同行评审的试点和可行性计划识别和培养新的GI研究者; v）促进C-SiG成员与马约和其他GI中心的其他GI研究者之间的协同相互作用，以促进由细胞治疗靶点的鉴定产生的临床试验; vi）与马约的其他NIDDK中心分享技术（例如，PKD中心）和现有的消化系统疾病研究核心中心，特别是在中西部（即中西部DDRCC联盟）。