Mayo Center for Cell Signaling in Gastroenterology

梅奥胃肠病学细胞信号转导中心

• 批准号: 10630250
• 负责人: Nicholas F. LaRusso
• 金额: $ 117.98万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10630250
• 关键词: Acceleration; Cell Communication; Cell Therapy; Cells; Clinic; Clinical; Clinical Trials; Collaborations; Diagnosis; Digestive System Disorders; Direct Costs; Discipline; Disease; Educational Curriculum; Educational workshop; Enteral; Environment; Epigenetic Process; Equipment; Faculty; Feedback; Focus Groups; Fostering; Funding; Gastroenterology; Gastrointestinal Diseases; Genes; Genetic; Goals; Grant; Growth; Health; Inflammation; Infrastructure; Institution; Interdisciplinary Study; Investigation; Investments; Knowledge; Liver; Manuscripts; Mentorship; Methodology; Microscopy; Midwestern United States; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Neurosciences; Optics; Pathogenesis; Pathway interactions; Patient Care; Patients; Peer Review; Prevention; Productivity; Public Health; Publications; Reagent; Research; Research Personnel; Research Support; Research Training; Resources; Science; Scientific Advances and Accomplishments; Scientist; Services; Signal Pathway; Signal Transduction; Structure; Technology; Technology Transfer; Therapeutic; Translations; Update; Visit; base; career development; cell transformation; cellular imaging; collaborative environment; cost; cost effective; epigenomics; gastrointestinal; health care service utilization; imaging capabilities; improved; innovation; intercellular communication; interest; member; multidisciplinary; novel; patient oriented; practical application; programs; quality assurance; response; sabbatical; symposium; therapeutic target; translational applications

PROJECT SUMMARY The overall objective of the Mayo Clinic Center for Cell Signaling in Gastroenterology (C-SiG) is to exploit signaling pathways in gastrointestinal cells to improve the health of patients with digestive diseases. To do this, C-SiG provides a robust infrastructure, thematic platforms, and career development opportunities to integrate and amplify impactful investigation along the discovery-translation-application paradigm. Our Research Base now consists of 68 scientists (15% growth) involving 18 departments and $23.7 million (direct costs, 2.5% growth) in digestive disease-related funding. Responding to members' evolving interests and scientific advances, we've re-aligned members into three interconnected Mechanistic Research Themes (intracellular signaling, cell-to-cell communication, and genetics/epigenetics), each intersecting with three Disease Focus Groups (liver pathobiology, enteric neurosciences, inflammation/transformation), a matrix that fosters both discovery and disease relevant investigation. Our ongoing CENTRAL HYPOTHESIS is that advances in care of patients with digestive diseases requires a facilitative infrastructure supporting meaningful interactions among multidisciplinary scientists investigating cellular mechanisms, pathways, and therapeutic targets to enhance rapid translation of basic discoveries into clinical trials. Our OVERALL SPECIFIC AIMS are to: i) Foster multidisciplinary research by expanding technical and collaborative capabilities of established GI scientists and attracting investigators from other disciplines; ii) Identify and nurture new GI investigators via a peer-reviewed Pilot and Feasibility (P/F) Program including career development workshops, curricula, and structured mentorship (19/26, 73% of P/F recipients achieving federal funding); iii) Offer core-based specialized equipment, technologies, methodologies, reagents, and expertise (Optical Microscopy, Clinical, and Gene Editing and Epigenomics Cores), with continuous core menu updates, quality assurance and assessments, and project management oversight in response to member feedback; iv) Support a robust Enrichment Program; and v) Promote interactions between C-SiG with other NIDDK centers at Mayo (e.g., PKD Center) and existing DDRCCs, especially in the Midwest (i.e., Midwest DDRCC Alliance). Our global efforts have resulted in 215 manuscripts, with 56% percent intra- and 44% inter-thematic publications (70% involving two or more members). Importantly, we've made critical advances in understanding disease pathogenesis relevant to signal transduction, cell-to-cell communication and genetics/epigenetics, thereby identifying potential disease modifying targets.

项目总结

项目成果

Autophagy-mediated reduction of miR-345 contributes to hepatic cystogenesis in polycystic liver disease.

• DOI: 10.1016/j.jhepr.2021.100345
• 发表时间: 2021-10
• 期刊: JHEP reports : innovation in hepatology
• 作者: Masyuk T;Masyuk A;Trussoni C;Howard B;Ding J;Huang B;LaRusso N
• 通讯作者: LaRusso N

Association of beclin 1 expression with response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal carcinoma.

• DOI: 10.1002/ijc.29496
• 发表时间: 2015-09-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Zaanan, Aziz;Park, Jae Myung;Tougeron, David;Huang, Shengbing;Wu, Tsung-Teh;Foster, Nathan R.;Sinicrope, Frank A.
• 通讯作者: Sinicrope, Frank A.

The cell biology of cryptosporidium infection.

• DOI: 10.1016/j.micinf.2011.03.008
• 发表时间: 2011-08
• 期刊: Microbes and infection
• 影响因子: 5.8
• 作者: O'Hara SP;Chen XM
• 通讯作者: Chen XM

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes.

• DOI: 10.1002/hep.28252
• 发表时间: 2016-03
• 期刊: Hepatology (Baltimore, Md.)
• 作者: Ibrahim SH;Hirsova P;Tomita K;Bronk SF;Werneburg NW;Harrison SA;Goodfellow VS;Malhi H;Gores GJ
• 通讯作者: Gores GJ

An aged immune system drives senescence and ageing of solid organs.

• DOI: 10.1038/s41586-021-03547-7
• 发表时间: 2021-06
• 期刊: Nature
• 影响因子: 64.8
• 作者: Yousefzadeh MJ;Flores RR;Zhu Y;Schmiechen ZC;Brooks RW;Trussoni CE;Cui Y;Angelini L;Lee KA;McGowan SJ;Burrack AL;Wang D;Dong Q;Lu A;Sano T;O'Kelly RD;McGuckian CA;Kato JI;Bank MP;Wade EA;Pillai SPS;Klug J;Ladiges WC;Burd CE;Lewis SE;LaRusso NF;Vo NV;Wang Y;Kelley EE;Huard J;Stromnes IM;Robbins PD;Niedernhofer LJ
• 通讯作者: Niedernhofer LJ