CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 由外力产生的临译势在必行！科学中心（CISC）已经开始改变哈佛及其附属的学术医疗中心（AHC）。这些机构拥有巨大的智力、人力和财政资源，长期以来一直保持着行政和财政独立，合作有限，特别是在临床和翻译领域！（C/T）研究。CTSC认可的重要性，加上参与全国性CTSA的机会，为哈佛大学、医学院及其AHC提供了杠杆作用，促使它们承诺提供大量新的资金，这些资金与NIH的资金相结合，确保了哈佛CTSC的成功。一个强大的和完全前所未有的治理模式，放弃最终权力的CTSC领导，已经开发和大学和AHCs的领导层认可。在每一节的开头都总结了一项全面的差距分析，得出的结论是，要取得成功，我们就必须把重点放在使信息和基础设施无障碍上，并把来自不同学科的调查人员聚集在一起。为此，我们的CTSC旨在：1）提高研究人员识别信息和访问资源和工具的能力，这些都是构思和成功完成C/T实验所必需的; 2）以团队为基础的方法吸引来自许多不同领域的专家，以解决C/T研究中具有挑战性的问题; 3）让传统上不从事C/T研究的学科以及工业界成员参与解决翻译挑战; 4）提供新的咨询和促进人力资源，以降低进行创新，合作和跨机构的C/T实验的障碍; 5）教育更广泛的哈佛研究社区的机会，挑战和C/T研究的目标; 6）提高C/T研究对服务不足的人群和社区的影响; 7）确保C/T研究的机会平等地提供给所有人。因此，我们将把重点放在从事这项工作的人及其培训上。我们将为他们提供资源和咨询，以确定相关的合作者进行成功的C/T实验。这种新的协作和跨学科环境，新的工具和新的概念方法，将促进翻译，这将导致实质性的发现，影响我们的病人和那些处于危险之中的健康。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The external force generated by the imperative to create a Clinical and Translationa! Science Center (CISC) has begun to transform Harvard and its affiliated Academic Healthcare Centers (AHCs). These institutions, with their enormous intellectual, human subject, and fiscal resources, have a long history of administrative and financial independence and limited collaboration, especially in the disciplines of clinical and translations! (C/T) research. The importance of CTSC recognition coupled with the opportunity to participate in the nationwide CTSA provided the leverage to induce Harvard University, the Medical School and its AHCs to commit substantial new funding that when combined with NIH dollars ensures the success of the Harvard CTSC. A powerful and completely unprecedented governance model, ceding final authority to the CTSC eadership, has been developed and endorsed by the leadership of the University and AHCs. A comprehensive gap analysis, summarized at the beginning of each Section, concluded that success would require us to focus on making information and infrastructure accessible and to bring investigators from diverse disciplines together. To this end, our CTSC is designed to: 1) enhance the ability of investigators to identify information and access resources and tools necessary to conceive and successfully complete C/T experiments; 2) engage experts from many diverse areas in a team-based approach to address challenging questions in C/T research; 3) involve academic disciplines not traditionally engaged in C/T research as well as members of industry in addressing translational challenges; 4) provide novel advisory and facilitative human resources to lower the barriers to performing innovative, collaborative, and cross-institutional C/T experiments; 5) educate the broader Harvard research community as to the opportunities, challenges, and goals of C/T research; 6) improve the impact of C/T research on underserved populations and communities; and 7) ensure that opportunities in C/T research are equally afforded to all. Therefore, we will focus on the people doing the work and their training. We will provide them with the resources and consultation to identify relevant collaborators to perform successful C/T experiments. This new collaborative and trans-disciplinary environment, with new tools and new conceptual approaches, will catalyze translation that will result in substantive discoveries impacting the health of our patients and those at risk.