HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 外力产生的势在必行，创造了临床与翻译a！科学中心(CISC)已经开始改变哈佛大学及其附属的学术医疗中心(AHC)。这些机构拥有巨大的智力、人力和财政资源，在行政和财务上独立的历史悠久，合作有限，特别是在临床和翻译领域！(C/T)研究。CTSC的重要性加上参与全国CTSA的机会提供了杠杆，促使哈佛大学、医学院及其AHC承诺提供大量新资金，再加上NIH的资金，确保了哈佛CTSC的成功。一种强大的、完全史无前例的治理模式--将最终权力让渡给CTSC教职人员--已经制定并得到了大学和AHCs领导层的支持。每一节开头总结的一项全面差距分析得出的结论是，要想取得成功，就需要我们把重点放在使信息和基础设施无障碍上，并把来自不同学科的调查人员聚集在一起。为此，我们的CTSC旨在：1)提高研究人员识别信息和获取构思并成功完成C/T实验所需的资源和工具的能力；2)以团队为基础的方法吸引来自多个不同领域的专家，以解决C/T研究中具有挑战性的问题；3)让传统上不从事C/T研究的学术学科以及行业成员参与解决翻译挑战；4)提供新颖的咨询和促进人力资源，以降低进行创新、协作和跨机构C/T实验的障碍；5)就C/T研究的机遇、挑战和目标对更广泛的哈佛研究界进行教育；6)改善C/T研究对未得到充分服务的人群和社区的影响；7)确保C/T研究的机会平等地给予所有人。因此，我们将重点放在做工作的人和他们的培训上。我们将为他们提供资源和咨询，以确定成功进行C/T实验的相关合作者。这种新的协作和跨学科的环境，加上新的工具和新的概念方法，将催化翻译，从而产生影响我们患者和风险患者健康的实质性发现。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The external force generated by the imperative to create a Clinical and Translationa! Science Center (CISC) has begun to transform Harvard and its affiliated Academic Healthcare Centers (AHCs). These institutions, with their enormous intellectual, human subject, and fiscal resources, have a long history of administrative and financial independence and limited collaboration, especially in the disciplines of clinical and translations! (C/T) research. The importance of CTSC recognition coupled with the opportunity to participate in the nationwide CTSA provided the leverage to induce Harvard University, the Medical School and its AHCs to commit substantial new funding that when combined with NIH dollars ensures the success of the Harvard CTSC. A powerful and completely unprecedented governance model, ceding final authority to the CTSC eadership, has been developed and endorsed by the leadership of the University and AHCs. A comprehensive gap analysis, summarized at the beginning of each Section, concluded that success would require us to focus on making information and infrastructure accessible and to bring investigators from diverse disciplines together. To this end, our CTSC is designed to: 1) enhance the ability of investigators to identify information and access resources and tools necessary to conceive and successfully complete C/T experiments; 2) engage experts from many diverse areas in a team-based approach to address challenging questions in C/T research; 3) involve academic disciplines not traditionally engaged in C/T research as well as members of industry in addressing translational challenges; 4) provide novel advisory and facilitative human resources to lower the barriers to performing innovative, collaborative, and cross-institutional C/T experiments; 5) educate the broader Harvard research community as to the opportunities, challenges, and goals of C/T research; 6) improve the impact of C/T research on underserved populations and communities; and 7) ensure that opportunities in C/T research are equally afforded to all. Therefore, we will focus on the people doing the work and their training. We will provide them with the resources and consultation to identify relevant collaborators to perform successful C/T experiments. This new collaborative and trans-disciplinary environment, with new tools and new conceptual approaches, will catalyze translation that will result in substantive discoveries impacting the health of our patients and those at risk.