The Psychobiology of Trauma and Resilience Across the Lifespan

描述（由申请人提供）：本申请旨在为在蒙特利尔（2010年11月4-6日）和洛杉矶（2012年11月1-3日）举行的第26、28和30届国际创伤应激研究学会（ISTSS）年会上的科学报告寻求资助，地点待定（2014年11月）。我们将复制目前nimh资助的会议拨款中使用的成功模式。每次会议都有一个核心的科学规划的基础和临床科学解决重要的创伤应激问题。暴露于潜在创伤性事件（pte）的发生率很高，如儿童虐待、人际暴力、灾难、恐怖主义和战争，暴露于pte会增加PTSD、抑郁症、物质使用障碍和暴力行为的风险。会议的规划将解决更好的创伤应激研究和将临床研究转化为临床实践的障碍，包括：1)所研究的创伤性精神创伤类型的碎片化；2)缺乏整合创伤应激研究，包括遗传、分子、行为、心理和公共卫生层面的分析和观点；3)未考虑儿童时期经历的创伤后应激障碍对生命后期暴露于创伤后应激障碍风险的发育影响；4)基础科学研究向临床研究、临床研究向临床和公共卫生实践的转化不佳。具体目标是：1)组织年度会议，让研究、临床实践和政策受众参与讨论基因、分子、行为、心理和社会对风险、恢复力、预防和治疗创伤后应激障碍及相关疾病的影响，以鼓励发展更好的研究和改进的护理；2)整合这些不同角度和分析层次的知识，以提高科学知识和科学知情的临床实践；3)通过《创伤应激杂志》的年度特刊向科学界传播有关重要会议主题和演讲的信息。在P.I.和项目协调委员会的指导下，2010年、2012年和2014年年会的20%内容将专门讨论这些问题。将选择主旨演讲、全体会议演讲和其他演讲，以确保有充分的这类规划。示范性报告将在ISTSS网站上进行总结，并且每年将在JTS上发表基于这些报告的特别部分。协调委员会将确保该项目包括妇女和传统上代表性不足的种族/少数民族。将获得与会者的调查反馈、媒体报道数据以及在JTS特别部分发表的文章的引用数据。注：根据新的NIMH会议资助政策，我们将使用额外的资助资金来实现一个完全可持续的年度会议，其中包括由资助可能实现的项目改进，因此不需要额外申请NIMH会议资助资金。

DESCRIPTION (provided by applicant): This application seeks funding for scientific presentations at the 26th, 28th, and 30th Annual Meetings of the International Society for Traumatic Stress Studies (ISTSS) to be held in Montreal (November 4-6, 2010), Los Angeles (November 1-3, 2012) and a site to be determined (November, 2014). We will replicate the successful model used in our current NIMH-funded conference grant. Each meeting has a core of scientific programming of basic and clinical science addressing important traumatic stress issues. The prevalence of exposure to potentially traumatic events (PTEs) such as child maltreatment, interpersonal violence, disasters, terrorism, and war is high, and exposure to PTEs increases risk of PTSD, depression, substance use disorders and perpetration of violence. Programming at the meetings will address barriers to better traumatic stress research and translation of clinical research to clinical practice that include: 1) fragmentation with respect to the types of PTEs studied; 2) lack of integration of traumatic stress research that incorporates genetic, molecular, behavioral, psychological, and public health levels of analysis and perspective; 3) failure to consider the developmental impact of PTEs experienced during childhood on risk for PTSD given exposure to PTEs occurring at later points during the lifespan; and 4) poor translation of basic science research to clinical research and of clinical research to clinical and public health practice. Specific aims are to: 1) organize annual meetings that engage research, clinical practice, and policy audiences in discussions about genetic, molecular, behavioral, psychological, and social influences on risk, resilience, prevention, and treatment of PTSD and related disorders in an effort to encourage development of better research and improved care; 2) integrate knowledge from these different perspectives and levels of analysis to improve scientific knowledge and scientifically informed clinical practice; and 3) disseminate information about key meeting themes and presentations to the scientific community via annual special sections in the Journal of Traumatic Stress. Under the direction of the P.I. and a Project Coordinating Committee, 20% of the content of the 2010, 2012, and 2014 Annual Meetings will be devoted to these issues. Keynote speakers, plenary speakers, and other presentations will be selected to insure that there is adequate programming of this type. Exemplary presentations will be summarized on the ISTSS website, and a special section based on these presentations will be published in JTS each year. The Coordinating Committee will insure that the program includes women and traditionally underrepresented racial/ethnic minorities. Survey feedback from meeting participants, data on media coverage, and citation data on articles published in Special Section of the JTS will be obtained. Note: Consistent with the new NIMH policy on conference grants, we will use the additional grant funding to achieve a fully sustainable annual meeting that incorporates program enhancements made possible by the grant so that no additional requests for NIMH conference grant funding will be necessary. PUBLIC HEALTH RELEVANCE: The proposed presentations within the 2010, 2012 and 2014 ISTSS annual Meetings are designed to address several barriers to improved traumatic stress research and clinical practice that include: 1) fragmentation with respect to type of potentially traumatic events (PTE) studied; 2) lack of integration of traumatic stress research that documents genetic, molecular, behavioral, psychological, or social findings or import to the field 3) failure to consider the developmental impact of PTEs experienced at different points in the lifespan; and 4) poor translation of research findings and their implications from traumatic stress researchers to clinical and public health practitioners. Specific aims are to: 1) organize annual meetings that engage research, practice, and policy audiences in a discussion about the genetic, molecular, behavioral, psychological, and social influences on resilience, prevention, and treatment of trauma-related problems in an effort to educate these disparate audiences and to encourage the development of innovative treatment and research; 2) integrate knowledge from genetic, biological, neuroscience, psychosocial, and public health perspectives to improve scientific knowledge and scientifically informed clinical practice and advocacy; and 3) disseminate information about key meeting themes and presentations to the scientific community via an annual special issues of the Journal of Traumatic Stress (JTS). This application seeks continued funding for a conference grant.