VITAMIN D STATUS AND IMPACT ON BONE MINERALIZATION IN HUMAN MILK FED HISPANIC

母乳喂养的西班牙裔人的维生素 D 状况及其对骨矿化的影响

• 批准号: 8356696
• 负责人: STEVEN A ABRAMS
• 金额: $ 4.15万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356696
• 关键词: 25-hydroxyvitamin D; Age-Months; Autoimmune Diseases; Birth; Bone Mineral Contents; Breast Feeding; Caucasians; Caucasoid Race; Child; Childhood; Cholecalciferol; Clinical Research; Data; Disease; Dual-Energy X-Ray Absorptiometry; Frequencies; Funding; Grant; Hispanics; Human Milk; Immune; Individual; Infant; Intake; Life; Link; Malignant Neoplasms; Measures; Milk; Minerals; Mothers; National Center for Research Resources; Newborn Infant; Nutritional; Outcome; Physiologic calcification; Predisposition; Principal Investigator; Public Health; Relative (related person); Reporting; Research; Research Infrastructure; Resources; Rickets; Risk; Serum; Skin; Source; Speed; Sun Exposure; Supplementation; Texas; Ultrasonography; Umbilical Cord Blood; United States National Institutes of Health; Urbanization; Vitamin D; Vitamin D Deficiency; bone; bone health; cohort; cost; feeding; fetal; follow-up; high risk; imprint; neonate; sound

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT Vitamin D deficiency is widespread and linked to decreased bone mineral content. Little data exists regarding the vitamin D status and the relationship of 25-OHD status to functional bone health outcomes in Hispanic infants. To evaluate this, we plan an observational cohort of full term, healthy, exclusively breastfed Hispanic and Caucasian infants. We hypothesize serum 25-OHD measured in cord blood will be significantly lower in Hispanic than Caucasian infants, with 25-OHD 50% of Hispanic neonates. Hypothesis #2: Speed of sound bone ultrasound (SOS U/S) and dual-energy X-ray absorptiometry (DXA) whole body bone mineral content measured in the first week of life will correlate positively with 25-OHD concentration in cord blood. Hypothesis #3: Supplementation with 400 IU/d of vitamin D3 from birth will allow all infants to achieve 25-OHD levels 20 ng/mL. Baseline-adjusted bone mineral content and SOS U/S will be significantly correlated with 25-OHD status at 3 months. II. SPECIFIC AIMS Primary Aim: To evaluate the relative frequency of vitamin D deficiency in human milk fed Hispanic compared to Caucasian newborn infants in Houston, Texas. Secondary Aims: To determine if infant vitamin D status is related to bone mineral status at birth and to determine the effects of vitamin D supplementation on 25-hydroxyvitamin D (25-OHD) concentration and bone mineral status vitamin D deficient and vitamin D replete infants at 3 months of age. III. BACKGROUND AND SIGNIFICANCE In recent years, severe vitamin D deficiency has resurfaced as a major public health concern. Nutritional rickets is widespread, and a recent report on this disease in Texas showed Hispanic children are at increased risk. Long-term follow-up has demonstrated that vitamin D deficient infants are more likely to have decreased bone mineral status in late childhood. Additionally, vitamin D deficiency has been linked to changes in fetal imprinting and increased susceptibility to autoimmune diseases, immune deficiency, and malignancy. At birth, an infants vitamin D status is entirely dependent on the vitamin D status of the mother. Many studies have shown vitamin D deficiency is very common in mother-child pairs, especially in dark-skinned individuals. However, few data exist regarding the vitamin D status in Hispanic infants. Low milk intakes and decreased sun exposure with urbanization makes this a very high-risk group among infants in Texas.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 摘要 维生素D缺乏症普遍存在，并与骨矿物质含量降低有关。关于西班牙裔婴儿的维生素D状态以及25-OHD状态与功能性骨健康结局之间的关系的数据很少。为了评估这一点，我们计划了一组足月、健康、纯母乳喂养的西班牙裔和高加索婴儿的观察队列。我们假设在脐带血中测得的25-OHD水平在拉美裔新生儿中显著低于高加索新生儿，其中西班牙裔新生儿中25-OHD占50%。 假设2：声速骨超声(SOS U/S)和双能X线骨密度仪(DXA)在出生第一周测量的全身骨矿含量将与脐血中25-OHD浓度呈正相关。 假设3：从出生起每天补充400IU维生素D3将使所有婴儿达到25-OHD水平20毫克/毫升。基线调整后的骨矿含量和SOSU/S将与3个月后的25-OHD状态显著相关。 二、具体目标 主要目的：评估德克萨斯州休斯敦西语裔母乳喂养的母乳中维生素D缺乏的相对频率与高加索新生儿的比较。 第二个目的：确定婴儿维生素D状况是否与出生时的骨矿物质状况有关，以及补充维生素D对婴儿出生3个月时的25-羟基维生素D(25-OHD)浓度和骨矿物质状况的影响。 三、背景和意义 近年来，严重的维生素D缺乏症再次成为一个主要的公共卫生问题。营养性软骨病很普遍，最近德克萨斯州一份关于这种疾病的报告显示，拉美裔儿童面临更高的风险。长期随访表明，维生素D缺乏的婴儿在儿童后期更有可能出现骨矿物质状态下降。此外，维生素D缺乏与胎儿印记的改变以及自身免疫性疾病、免疫缺陷和恶性肿瘤的易感性增加有关。在出生时，婴儿的维生素D状态完全取决于母亲的维生素D状态。许多研究表明，维生素D缺乏在母子配对中非常普遍，特别是在皮肤黝黑的人身上。然而，关于西班牙裔婴儿维生素D状况的数据很少。低牛奶摄入量和城市化带来的日照减少，使这一群体成为德克萨斯州婴儿的高危人群。