COMPASSIONATE USE OF AN INTRAVENOUS FAT EMULSION COMPRISED OF FSIH OIL IN THE TR

在 TR 中善意地使用由 FSIH 油组成的静脉脂肪乳剂

基本信息

  • 批准号:
    8356700
  • 负责人:
  • 金额:
    $ 2.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-12-01 至 2011-11-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT We propose to provide an omega-6 predominant lipid infusion (Omegaven) to patients with severe parenteral nutrition associated cholestasis (conjugated bilirubin 6) on a compassionate use basis. We will monitor for safety parameters during the maximum 5 months of intervention. The Omegaven will be intravenously infused at a dose of 1gm/kg/day until the infant is weaned from parenteral nutrition and for no longer than 5 months. This is a continuation of protocol H-21344. I. HYPOTHESIS Not applicable due to the compassionate use nature of this protocol. II. SPECIFIC AIMS To provide a mechanism for critically ill infants with parenteral nutrition (PN) associated cholestasis to receive Omegaven for compassionate use situations for which there are no satisfactory alternative treatments. III. BACKGROUND AND SIGNIFICANCE Parenteral nutrition (PN) provides intravenous nutritional supplementation for patients unable to absorb adequate enteral nutrients secondary to insufficient intestinal length or function. PN contains the macronutrient building blocks of the human diet in their most elemental forms (amino acids and dextrose) and is commonly administered with a lipid emulsion to avoid essential fatty acid deficiency and to provide a calorically dense source of non-protein calories. In addition, PN contains the essential micronutrients (electrolytes, trace elements, and vitamins) to provide an optimal nutritional regimen. Before the development of PN in the late 1960s, patients with insufficient gastrointestinal absorptive function commonly died of starvation and subsequent complications of malnutrition (1, 2). Today, more than 30,000 patients are permanently dependent on parenteral nutrition for survival. However, PN continues to be associated with hepatic injury that occurs at an unpredictable rate and includes both biochemical, i.e., elevated serum aminotransferase and alkaline phosphatase, and histologic alterations such as steatosis, steatohepatitis, lipidosis, cholestasis, fibrosis, and cirrhosis (3, 4). These abnormalities, which may worsen with the duration of PN administration, is more prevalent in the pediatric population. Additional risk factors for this condition include prematurity, low birth weight, long-term use of PN, the lack of concomitant enteral intake, sepsis, and multiple operative procedures (5). Although the pathological features of PN-induced liver injury have been well described, the etiology, prevention, and treatment of this complication are not well understood. Multiple hypotheses exist to explain the pathogenesis of PN-induced liver injury including altered gut hormonal profiles (6), the propensity for bacterial translocation in the absence of enteral intake (7, 8), intestinal stasis resulting in the reduced clearance of hepatotoxic bile acids (8), and direct deficiencies or toxic components of the PN solution itself resulting in excessive glucose calorie uptake, excessive lipid infusion, or nutritional deficiencies such as essential fatty acid deficiency (9-11). None of these theories has been confirmed consistently. The etiology of PN-associated hepatotoxicity is currently considered multifactorial. Available treatment options for this disease process are limited and have achieved moderate success at best. Care of the PN-dependent patient is focused on gradually increasing enteral caloric intake as the residual bowel adapts allowing PN to be discontinued (12). In fact, it has been shown both experimentally and clinically that partial enteral nutrition, when tolerated, helps to protect against the development of PN-associated liver injury (13-15). In severe cases of refractory hepatic failure, liver transplantation with or without accompanying small bowel transplantation remains the only treatment option. The mechanism of clearance of omega-3 fatty acid containing lipid emulsions is unknown, but appears to be largely independent of the pathways identified above (17). Furthermore, omega-3 fatty acid solutions have been shown to decrease de novo lipogenesis (18), prevent or attenuate PN-induced hepatosteatosis in rats (19) and guinea pigs and ameliorate the severity of high-fat diet-induced hepatosteatosis in rats (20). In addition, omega-3 fatty acids can interfere with the arachidonic acid pathway of inflammation (18, 21). They can displace arachidonic acid from tissue fatty acid pools, thereby reducing the availability for eicasanoid-synthesizing enzymes and inflammation (21).
这个子项目是利用这些资源的众多研究子项目之一

项目成果

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STEVEN A ABRAMS其他文献

STEVEN A ABRAMS的其他文献

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{{ truncateString('STEVEN A ABRAMS', 18)}}的其他基金

EVALUATION OF THE USE OF DONOR HUMAN MILK FOR INFANTS WITH ABDOMINAL WALL DEFECT
腹壁缺陷婴儿使用供者母乳的评估
  • 批准号:
    8356736
  • 财政年份:
    2010
  • 资助金额:
    $ 2.59万
  • 项目类别:
EVALUATION OF CALCIUM, VITAMIN D, MAGNESIUM AND ZINC ABSORPTION IN HEALTHY
评估钙、维生素 D、镁和锌的健康吸收情况
  • 批准号:
    8356713
  • 财政年份:
    2010
  • 资助金额:
    $ 2.59万
  • 项目类别:
ZINC AND COPPER EXCRETION AND ABSORPTION IN INFANTS WITH OSTOMIES
造口婴儿的锌和铜排泄和吸收
  • 批准号:
    8356699
  • 财政年份:
    2010
  • 资助金额:
    $ 2.59万
  • 项目类别:
VITAMIN D STATUS AND IMPACT ON BONE MINERALIZATION IN HUMAN MILK FED HISPANIC
母乳喂养的西班牙裔人的维生素 D 状况及其对骨矿化的影响
  • 批准号:
    8356696
  • 财政年份:
    2010
  • 资助金额:
    $ 2.59万
  • 项目类别:
QUALITY IMPROVEMENT PROJECT - EVALUATION OF CURRENT STANDARD OF CARE
质量改进项目 - 评估当前护理标准
  • 批准号:
    8356752
  • 财政年份:
    2010
  • 资助金额:
    $ 2.59万
  • 项目类别:
ZINC AND COPPER EXCRETION AND ABSORPTION IN INFANTS WITH OSTOMIES
造口婴儿的锌和铜排泄和吸收
  • 批准号:
    8166718
  • 财政年份:
    2009
  • 资助金额:
    $ 2.59万
  • 项目类别:
EVALUATION OF THE USE OF DONOR HUMAN MILK FOR INFANTS WITH ABDOMINAL WALL DEFECT
腹壁缺陷婴儿使用供者母乳的评估
  • 批准号:
    8166750
  • 财政年份:
    2009
  • 资助金额:
    $ 2.59万
  • 项目类别:
Enhancing Dietary Iron and Zinc Bioavailability in Indian Children
提高印度儿童膳食铁和锌的生物利用度
  • 批准号:
    7665615
  • 财政年份:
    2009
  • 资助金额:
    $ 2.59万
  • 项目类别:
VITAMIN D STATUS AND IMPACT ON BONE MINERALIZATION IN HUMAN MILK FED HISPANIC
母乳喂养的西班牙裔人的维生素 D 状况及其对骨矿化的影响
  • 批准号:
    8166715
  • 财政年份:
    2009
  • 资助金额:
    $ 2.59万
  • 项目类别:
NUTRITIONAL MANAGEMENT OF INFANTS WITH BRONCHOPULMONARY DYSPLASIA (BPD): EFFE
支气管肺发育不良 (BPD) 婴儿的营养管理:EFFE
  • 批准号:
    8166685
  • 财政年份:
    2009
  • 资助金额:
    $ 2.59万
  • 项目类别:

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