VITAMIN D STATUS AND IMPACT ON BONE MINERALIZATION IN HUMAN MILK FED HISPANIC

母乳喂养的西班牙裔人的维生素 D 状况及其对骨矿化的影响

• 批准号: 8166715
• 负责人: STEVEN A ABRAMS
• 金额: $ 6.01万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166715
• 关键词: 25-hydroxyvitamin D; Age-Months; Autoimmune Diseases; Birth; Bone Mineral Contents; Breast Feeding; Calcium; Caucasians; Caucasoid Race; Child; Childhood; Cholecalciferol; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Dual-Energy X-Ray Absorptiometry; Frequencies; Funding; Grant; Hispanics; Human Milk; Immune; Individual; Infant; Institution; Intake; Intervention; Link; Malignant Neoplasms; Measures; Milk; Minerals; Mothers; Newborn Infant; Nutritional; Outcome; Parathyroid Hormones; Physiologic calcification; Predisposition; Public Health; Relative (related person); Reporting; Research; Research Personnel; Resources; Rickets; Risk; Serum; Skin; Son of Sevenless Proteins; Source; Sun Exposure; Supplementation; Texas; Umbilical Cord Blood; United States National Institutes of Health; Urbanization; Vitamin D; Vitamin D Deficiency; Vitamins; bone; bone health; cohort; design; feeding; fetal; follow-up; high risk; human PTH protein; imprint; neonate; randomized trial

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vitamin D deficiency is widespread and linked to decreased bone mineral content. Little data exists regarding the vitamin D status and the relationship of 25-OHD status to functional bone health outcomes in Hispanic infants. To evaluate this, we plan an observational cohort of full term, healthy, exclusively breastfed Hispanic and Caucasian infants. We hypothesize serum 25-OHD measured in cord blood will be significantly lower in Hispanic than Caucasian infants, with 25-OHD < 20 ng/mL found in at least 50% of Hispanic neonates. 25-OHD, ionized calcium, and parathyroid hormone will be measured on cord blood. Secondary aims evaluate the relationship between 25-OHD levels and bone mineral status at baseline and after 3 months of 400 IU/day supplemental vitamin D3. Whole body DXA and SOS U/S will be measured shortly after birth, then again after supplementation. Data from this study will provide information needed to design further randomized trials and interventions. Primary Aim: To evaluate the relative frequency of vitamin D deficiency in human milk fed Hispanic compared to Caucasian newborn infants in Houston, Texas. Secondary Aims: To determine if infant vitamin D status is related to bone mineral status at birth and to determine the effects of vitamin D supplementation on 25-hydroxyvitamin D (25-OHD) concentration and bone mineral status vitamin D deficient and vitamin D replete infants at 3 months of age. In recent years, severe vitamin D deficiency has resurfaced as a major public health concern. Nutritional rickets is widespread, and a recent report on this disease in Texas showed Hispanic children are at increased risk. Long-term follow-up has demonstrated that vitamin D deficient infants are more likely to have decreased bone mineral status in late childhood. Additionally, vitamin D deficiency has been linked to changes in fetal imprinting and increased susceptibility to autoimmune diseases, immune deficiency, and malignancy. At birth, an infant s vitamin D status is entirely dependent on the vitamin D status of the mother. Many studies have shown vitamin D deficiency is very common in mother-child pairs, especially in dark-skinned individuals. However, few data exist regarding the vitamin D status in Hispanic infants. Low milk intakes and decreased sun exposure with urbanization makes this a very high-risk group among infants in Texas.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 维生素D缺乏症普遍存在，并与骨矿物质含量降低有关。关于西班牙裔婴儿的维生素D状态以及25-OHD状态与功能性骨健康结局之间的关系的数据很少。为了评估这一点，我们计划了一组足月、健康、纯母乳喂养的西班牙裔和高加索婴儿的观察队列。我们假设在脐带血中测得的25-OHD将显著低于高加索新生儿，至少50%的拉美裔新生儿中发现25-OHD和20 ng/mL。将在脐带血上测量25-OHD、离子钙和甲状旁腺激素。次要目的是评估在基线和每日补充维生素D3 400IU后3个月，25-OHD水平与骨矿物质状态之间的关系。出生后即刻测量全身DXA和SOSU/S，补充后再次测量。这项研究的数据将提供设计进一步随机试验和干预所需的信息。 主要目的：评估德克萨斯州休斯敦西语裔母乳喂养的母乳中维生素D缺乏的相对频率与高加索新生儿的比较。 第二个目的：确定婴儿维生素D状况是否与出生时的骨矿物质状况有关，以及补充维生素D对婴儿出生3个月时的25-羟基维生素D(25-OHD)浓度和骨矿物质状况的影响。 近年来，严重的维生素D缺乏症再次成为一个主要的公共卫生问题。营养性软骨病很普遍，最近德克萨斯州一份关于这种疾病的报告显示，拉美裔儿童面临更高的风险。长期随访表明，维生素D缺乏的婴儿在儿童后期更有可能出现骨矿物质状态下降。此外，维生素D缺乏与胎儿印记的改变以及自身免疫性疾病、免疫缺陷和恶性肿瘤的易感性增加有关。出生时，婴儿S的维生素D状况完全取决于母亲的维生素D状况。许多研究表明，维生素D缺乏在母子配对中非常普遍，特别是在皮肤黝黑的人身上。然而，关于西班牙裔婴儿维生素D状况的数据很少。低牛奶摄入量和城市化带来的日照减少，使这一群体成为德克萨斯州婴儿的高危人群。