VITAMIN D STATUS AND IMPACT ON BONE MINERALIZATION IN HUMAN MILK FED HISPANIC

母乳喂养的西班牙裔人的维生素 D 状况及其对骨矿化的影响

• 批准号: 8166715
• 负责人: STEVEN A ABRAMS
• 金额: $ 6.01万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166715
• 关键词: 25-hydroxyvitamin D; Age-Months; Autoimmune Diseases; Birth; Bone Mineral Contents; Breast Feeding; Calcium; Caucasians; Caucasoid Race; Child; Childhood; Cholecalciferol; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Dual-Energy X-Ray Absorptiometry; Frequencies; Funding; Grant; Hispanics; Human Milk; Immune; Individual; Infant; Institution; Intake; Intervention; Link; Malignant Neoplasms; Measures; Milk; Minerals; Mothers; Newborn Infant; Nutritional; Outcome; Parathyroid Hormones; Physiologic calcification; Predisposition; Public Health; Relative (related person); Reporting; Research; Research Personnel; Resources; Rickets; Risk; Serum; Skin; Son of Sevenless Proteins; Source; Sun Exposure; Supplementation; Texas; Umbilical Cord Blood; United States National Institutes of Health; Urbanization; Vitamin D; Vitamin D Deficiency; Vitamins; bone; bone health; cohort; design; feeding; fetal; follow-up; high risk; human PTH protein; imprint; neonate; randomized trial

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vitamin D deficiency is widespread and linked to decreased bone mineral content. Little data exists regarding the vitamin D status and the relationship of 25-OHD status to functional bone health outcomes in Hispanic infants. To evaluate this, we plan an observational cohort of full term, healthy, exclusively breastfed Hispanic and Caucasian infants. We hypothesize serum 25-OHD measured in cord blood will be significantly lower in Hispanic than Caucasian infants, with 25-OHD < 20 ng/mL found in at least 50% of Hispanic neonates. 25-OHD, ionized calcium, and parathyroid hormone will be measured on cord blood. Secondary aims evaluate the relationship between 25-OHD levels and bone mineral status at baseline and after 3 months of 400 IU/day supplemental vitamin D3. Whole body DXA and SOS U/S will be measured shortly after birth, then again after supplementation. Data from this study will provide information needed to design further randomized trials and interventions. Primary Aim: To evaluate the relative frequency of vitamin D deficiency in human milk fed Hispanic compared to Caucasian newborn infants in Houston, Texas. Secondary Aims: To determine if infant vitamin D status is related to bone mineral status at birth and to determine the effects of vitamin D supplementation on 25-hydroxyvitamin D (25-OHD) concentration and bone mineral status vitamin D deficient and vitamin D replete infants at 3 months of age. In recent years, severe vitamin D deficiency has resurfaced as a major public health concern. Nutritional rickets is widespread, and a recent report on this disease in Texas showed Hispanic children are at increased risk. Long-term follow-up has demonstrated that vitamin D deficient infants are more likely to have decreased bone mineral status in late childhood. Additionally, vitamin D deficiency has been linked to changes in fetal imprinting and increased susceptibility to autoimmune diseases, immune deficiency, and malignancy. At birth, an infant s vitamin D status is entirely dependent on the vitamin D status of the mother. Many studies have shown vitamin D deficiency is very common in mother-child pairs, especially in dark-skinned individuals. However, few data exist regarding the vitamin D status in Hispanic infants. Low milk intakes and decreased sun exposure with urbanization makes this a very high-risk group among infants in Texas.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 维生素D缺乏症很普遍，与骨矿物质含量下降有关。 关于西班牙裔婴儿的维生素D状态和25-OHD状态与功能性骨健康结果的关系，几乎没有数据。 为了评估这一点，我们计划对足月、健康、纯母乳喂养的西班牙裔和白人婴儿进行观察。 我们假设在脐带血中测量的血清25-OHD在西班牙裔婴儿中显著低于白人婴儿，在至少50%的西班牙裔新生儿中发现25-OHD < 20 ng/mL。 将测量脐带血中的25-OHD、离子钙和甲状旁腺激素。 次要目的是评估基线时和补充400 IU/天维生素D3 3 3个月后25-OHD水平与骨矿物质状态之间的关系。 全身DXA和SOS U/S将在出生后不久测量，然后在补充后再次测量。 本研究的数据将为设计进一步的随机试验和干预措施提供所需的信息。 主要目的：评价在德克萨斯州休斯顿，西班牙裔人喂养的母乳与白人新生儿喂养的母乳相比维生素D缺乏的相对频率。 次要目标：确定婴儿维生素D状态是否与出生时的骨矿物质状态相关，并确定维生素D补充对3个月龄时维生素D缺乏和维生素D充足婴儿的25-羟基维生素D（25-OHD）浓度和骨矿物质状态的影响。 近年来，严重的维生素D缺乏症重新成为一个主要的公共卫生问题。营养性佝偻病很普遍，最近在德克萨斯州的一份关于这种疾病的报告显示，西班牙裔儿童的风险增加。长期随访表明，维生素D缺乏的婴儿更有可能在儿童晚期出现骨矿物质状态下降。此外，维生素D缺乏症与胎儿印记的变化以及对自身免疫性疾病、免疫缺陷和恶性肿瘤的易感性增加有关。出生时，婴儿的维生素D状况完全取决于母亲的维生素D状况。许多研究表明，维生素D缺乏症在母亲和孩子中非常常见，特别是在深色皮肤的人中。然而，关于西班牙裔婴儿维生素D状况的数据很少。低牛奶摄入量和城市化导致的阳光照射减少使德克萨斯州的婴儿成为一个非常高风险的群体。