ZINC AND COPPER EXCRETION AND ABSORPTION IN INFANTS WITH OSTOMIES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 摘要 我们建议检查造口婴儿对锌和铜的吸收和排泄。这将通过测量基线排泄量和血清锌、铜和铜蓝蛋白水平，并通过利用锌和铜的稳定同位素来测量吸收和排泄来实现。当造口婴儿主要接受全肠外营养(TPN)，只需少量或不经肠道喂养时，我们将收集造口输出量24小时，以测量锌和铜的排泄，并测量血清锌、铜和铜蓝蛋白水平。我们将在两个时间点使用稳定的锌和铜同位素：当婴儿仍在造口并在没有TPN的情况下接受主要的肠内营养时，以及当/如果患者切除造口并重新吻合肠道且患者的肠道喂养稳定时。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT We propose to examine the absorption and excretion of zinc and copper in infants with ostomies. This will be accomplished by measuring baseline excretion and serum levels of zinc, copper, and ceruloplasmin, and by utilizing stable isotopes of zinc and copper to measure absorption and excretion. When an infant with an ostomy is receiving primarily total parenteral nutrition (TPN) with minimal or no enteral feeds, we will collect ostomy output for 24 hours to measure zinc and copper excretion, and will measure serum zinc, copper, and ceruloplasmin levels. We will utilize stable isotopes of zinc and copper at two time points: when the infant still has the ostomy and is receiving primarily enteral nutrition without TPN, and lastly, when/if the patients ostomy is removed with the bowels reanastamosed and the patient is stable on enteral feeds.