EVALUATION OF CALCIUM, VITAMIN D, MAGNESIUM AND ZINC ABSORPTION IN HEALTHY

评估钙、维生素 D、镁和锌的健康吸收情况

• 批准号: 8356713
• 负责人: STEVEN A ABRAMS
• 金额: $ 10.33万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356713
• 关键词: Affect; Age; Calcium; Child; Cholecalciferol; Clinical Research; Copper; Data; Development; Diet; Evaluation; Funding; Goals; Grant; Health; Human Experimentation; Intake; Iron; Magnesium; Methods; Minerals; Minerals Nutrition; National Center for Research Resources; Nutritional; Outcome; Population Study; Principal Investigator; Recommendation; Research; Research Infrastructure; Resources; Source; Supplementation; Techniques; United States National Institutes of Health; Vitamin D; Zinc; absorption; base; calcium absorption; control trial; cost; evidence base; nutritional guideline; stable isotope

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT The goal of our research is to provide data to enhance the development of nutritional guidelines, especially as related to mineral nutrition, in children. Using human experimentation, we are studying methods of delivering the key minerals of calcium, zinc and iron in the diet so as to optimize health outcomes. We will conduct a controlled trial of vitamin D supplementation to assess the effects of vitamin D status on calcium absorption in small children. We will evaluate the effects of differing intakes of zinc on zinc and copper absorption. These studies will utilize stable isotope techniques so as to provide accurate, practically applicable information which may be obtained from the study populations in a safe manner. These data will have global application and provide a strong basis for evidence-based nutritional recommendations to be developed. I. HYPOTHESIS Hypothesis #1: Calcium absorption will not be significantly affected by providing children 8 weeks of supplementation with 1000 IU/d of vitamin D3. Hypothesis #2: There will be no significant relationship between intake and true dietary absorption of zinc. There will be a significant negative relationship between magnesium intake and absorption efficiency. II. SPECIFIC AIMS Objective #1: To evaluate the effects of supplemental vitamin D in enhancing calcium absorption in healthy children 4 to 8 yrs of age. Objective #2: Assess the absorption of magnesium and zinc in healthy children 4 to 8 yrs of age.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 摘要 我们研究的目标是提供数据，以加强儿童营养指南的制定，特别是与矿物质营养有关的营养指南。通过人体实验，我们正在研究在饮食中提供钙，锌和铁等关键矿物质的方法，以优化健康结果。我们将进行一项补充维生素D的对照试验，以评估维生素D状况对幼儿钙吸收的影响。我们将评估不同锌摄入量对锌和铜吸收的影响。这些研究将利用稳定同位素技术，以提供准确、实际适用的信息，这些信息可以安全的方式从研究人群中获得。这些数据将在全球范围内应用，并为制定基于证据的营养建议提供坚实的基础。 I. 假设 假设#1：为儿童提供8周补充1000 IU/d维生素D3不会显著影响钙的吸收。 假设#2：锌的摄入量和实际膳食吸收量之间没有显着关系。镁摄入量与吸收效率呈显著负相关。 二. 具体目标 目的#1：评估补充维生素D对4至8岁健康儿童钙吸收的影响。 目的#2：评估4至8岁健康儿童对镁和锌的吸收。