EVALUATION OF CALCIUM, VITAMIN D, MAGNESIUM AND ZINC ABSORPTION IN HEALTHY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 摘要 我们研究的目的是提供数据，以加强儿童营养指南的制定，特别是与矿物质营养有关的指南。利用人体实验，我们正在研究在饮食中输送关键矿物质钙、锌和铁的方法，以优化健康结果。我们将进行一项维生素D补充剂的对照试验，以评估维生素D状态对儿童钙吸收的影响。我们将评估不同锌摄入量对锌和铜吸收的影响。这些研究将利用稳定的同位素技术，以便以安全的方式提供可从研究人群中获得的准确、实用的信息。这些数据将在全球范围内应用，并为开发基于证据的营养建议提供强有力的基础。 一、假说 假设1：每天给儿童补充1000IU的维生素D3，对钙的吸收不会有显著影响。 假设2：锌的摄入量和膳食中的真实摄入量之间没有显著关系。镁摄入量与吸收效率之间存在显著的负相关关系。 二、具体目标 目的1：评价补充维生素D对4~8岁健康儿童钙吸收的促进作用。 目的#2：评估4-8岁健康儿童对镁和锌的吸收情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT The goal of our research is to provide data to enhance the development of nutritional guidelines, especially as related to mineral nutrition, in children. Using human experimentation, we are studying methods of delivering the key minerals of calcium, zinc and iron in the diet so as to optimize health outcomes. We will conduct a controlled trial of vitamin D supplementation to assess the effects of vitamin D status on calcium absorption in small children. We will evaluate the effects of differing intakes of zinc on zinc and copper absorption. These studies will utilize stable isotope techniques so as to provide accurate, practically applicable information which may be obtained from the study populations in a safe manner. These data will have global application and provide a strong basis for evidence-based nutritional recommendations to be developed. I. HYPOTHESIS Hypothesis #1: Calcium absorption will not be significantly affected by providing children 8 weeks of supplementation with 1000 IU/d of vitamin D3. Hypothesis #2: There will be no significant relationship between intake and true dietary absorption of zinc. There will be a significant negative relationship between magnesium intake and absorption efficiency. II. SPECIFIC AIMS Objective #1: To evaluate the effects of supplemental vitamin D in enhancing calcium absorption in healthy children 4 to 8 yrs of age. Objective #2: Assess the absorption of magnesium and zinc in healthy children 4 to 8 yrs of age.