ZINC AND COPPER EXCRETION AND ABSORPTION IN INFANTS WITH OSTOMIES

造口婴儿的锌和铜排泄和吸收

基本信息

  • 批准号:
    8166718
  • 负责人:
  • 金额:
    $ 1.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-12-01 至 2010-11-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to examine the absorption and excretion of zinc and copper in infants with ostomies. This will be accomplished by measuring baseline excretion and serum levels of zinc, copper, and ceruloplasmin, and by utilizing stable isotopes of zinc and copper to measure absorption and excretion. When an infant with an ostomy is receiving primarily total parenteral nutrition (TPN) with minimal or no enteral feeds, we will collect ostomy output for 24 hours to measure zinc and copper excretion, and will measure serum zinc, copper, and ceruloplasmin levels. We will utilize stable isotopes of zinc and copper at two time points: when the infant still has the ostomy and is receiving primarily enteral nutrition without TPN, and lastly, when/if the patient s ostomy is removed with the bowels reanastamosed and the patient is stable on enteral feeds. For the first part of the study, excretion data for zinc will be obtained for ostomy patients. We hypothesize that infants with an ostomy will excrete more zinc in their stools than healthy term or preterm infants without ostomies. For the second part of the study, we will obtain data on zinc absorption, secretion, and excretion through use of stable isotopes. Jalla et al determined that healthy infants retain zinc of 0.4 mg/day. We hypothesize that due to increased zinc losses, the infants in the study will be less positive than the healthy infants in the study by Jalla et al. Our study is designed to be able to detect if the ostomy patients net retention is one-half that described by Jalla (i.e. 0.2 mg/d). We will also obtain data on copper absorption, secretion, and excretion through the use of stable isotopes in the second part of the study. As a pilot study, we do not fully know what to expect regarding copper levels in infants with ostomies, but we hypothesize that they may be less positive than healthy infants without ostomies. Also, we hypothesize that zinc and copper are competitively absorbed in the gut; therefore, infants who receive more zinc may absorb less copper. For the third part of the study, we will obtain data on zinc absorption through the use of stable isotopes after the infant has had surgery to reanastamose the bowel. We hypothesize that there may be continued zinc losses above those documented for healthy infants who have never had an ostomy, but decreased losses compared to when the infant had an ostomy. To determine how the presence of an ileostomy impacts zinc and copper metabolism in infants at three time points: 1) when the infant has an ostomy and is receiving the majority of calories from total parenteral nutrition (TPN); 2) when the infant has an ostomy and is receiving primarily enteral nutrition without TPN; and 3) when/if the infant has a surgery to reconnect the bowel and is receiving primarily enteral nutrition. The primary objective of this study revolves around part 2, the stable isotope portion of zinc and copper absorption, secretion, and excretion in infants with an ostomy. There is currently no data available in this population for zinc balance.
这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得了主要资金, 因此可以在其他CRISP条目中表示。所列机构为 研究中心,而研究中心不一定是研究者所在的机构。 我们建议检查锌和铜的吸收和排泄的婴儿与造口术。这将通过测量锌、铜和血浆铜蓝蛋白的基线排泄和血清水平,以及通过利用锌和铜的稳定同位素测量吸收和排泄来实现。当造口术婴儿主要接受全肠外营养(TPN),很少或没有肠内喂养时,我们将收集24小时造口术排出物以测量锌和铜排泄,并测量血清锌、铜和铜蓝蛋白水平。我们将在两个时间点使用锌和铜的稳定同位素:当婴儿仍然有造口术并主要接受肠内营养而不接受TPN时,最后,当/如果患者的造口术被移除,肠道重新吻合,并且患者在肠内喂养方面稳定时。 对于研究的第一部分,将获得造口患者的锌排泄数据。 我们假设,与健康的足月儿或早产儿相比,有造口术的婴儿在粪便中排出更多的锌。 对于研究的第二部分,我们将通过使用稳定同位素获得锌吸收、分泌和排泄的数据。Jalla等人确定,健康婴儿的锌含量为0.4 mg/天。我们假设,由于锌损失增加,研究中的婴儿将比Jalla等人研究中的健康婴儿阳性率低。我们的研究旨在检测造口术患者的净潴留是否为Jalla描述的一半(即0.2 mg/d)。我们还将在研究的第二部分中通过使用稳定同位素获得关于铜吸收、分泌和排泄的数据。作为一项试点研究,我们并不完全知道造口婴儿的铜水平,但我们假设他们可能比没有造口的健康婴儿更不积极。此外,我们假设锌和铜在肠道中竞争性吸收;因此,接受更多锌的婴儿可能吸收较少的铜。 对于研究的第三部分,我们将通过使用稳定同位素获得婴儿手术后肠道再吻合的锌吸收数据。我们假设,可能有持续的锌损失高于那些记录的健康婴儿谁从来没有做过造口术,但减少损失相比,当婴儿有造口术。 确定回肠造口的存在如何影响婴儿在三个时间点的锌和铜代谢:1)婴儿进行造口并接受来自全肠外营养(TPN)的大部分热量时; 2)婴儿进行造口并主要接受肠内营养(不含TPN)时;以及3)当/如果婴儿进行了重新连接肠的手术并且主要接受肠内营养时。 本研究的主要目的围绕第2部分,锌和铜的吸收,分泌和排泄的婴儿造口术的稳定同位素部分。目前尚无该人群的锌平衡数据。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

STEVEN A ABRAMS其他文献

STEVEN A ABRAMS的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('STEVEN A ABRAMS', 18)}}的其他基金

EVALUATION OF THE USE OF DONOR HUMAN MILK FOR INFANTS WITH ABDOMINAL WALL DEFECT
腹壁缺陷婴儿使用供者母乳的评估
  • 批准号:
    8356736
  • 财政年份:
    2010
  • 资助金额:
    $ 1.55万
  • 项目类别:
EVALUATION OF CALCIUM, VITAMIN D, MAGNESIUM AND ZINC ABSORPTION IN HEALTHY
评估钙、维生素 D、镁和锌的健康吸收情况
  • 批准号:
    8356713
  • 财政年份:
    2010
  • 资助金额:
    $ 1.55万
  • 项目类别:
ZINC AND COPPER EXCRETION AND ABSORPTION IN INFANTS WITH OSTOMIES
造口婴儿的锌和铜排泄和吸收
  • 批准号:
    8356699
  • 财政年份:
    2010
  • 资助金额:
    $ 1.55万
  • 项目类别:
COMPASSIONATE USE OF AN INTRAVENOUS FAT EMULSION COMPRISED OF FSIH OIL IN THE TR
在 TR 中善意地使用由 FSIH 油组成的静脉脂肪乳剂
  • 批准号:
    8356700
  • 财政年份:
    2010
  • 资助金额:
    $ 1.55万
  • 项目类别:
VITAMIN D STATUS AND IMPACT ON BONE MINERALIZATION IN HUMAN MILK FED HISPANIC
母乳喂养的西班牙裔人的维生素 D 状况及其对骨矿化的影响
  • 批准号:
    8356696
  • 财政年份:
    2010
  • 资助金额:
    $ 1.55万
  • 项目类别:
QUALITY IMPROVEMENT PROJECT - EVALUATION OF CURRENT STANDARD OF CARE
质量改进项目 - 评估当前护理标准
  • 批准号:
    8356752
  • 财政年份:
    2010
  • 资助金额:
    $ 1.55万
  • 项目类别:
EVALUATION OF THE USE OF DONOR HUMAN MILK FOR INFANTS WITH ABDOMINAL WALL DEFECT
腹壁缺陷婴儿使用供者母乳的评估
  • 批准号:
    8166750
  • 财政年份:
    2009
  • 资助金额:
    $ 1.55万
  • 项目类别:
Enhancing Dietary Iron and Zinc Bioavailability in Indian Children
提高印度儿童膳食铁和锌的生物利用度
  • 批准号:
    7665615
  • 财政年份:
    2009
  • 资助金额:
    $ 1.55万
  • 项目类别:
VITAMIN D STATUS AND IMPACT ON BONE MINERALIZATION IN HUMAN MILK FED HISPANIC
母乳喂养的西班牙裔人的维生素 D 状况及其对骨矿化的影响
  • 批准号:
    8166715
  • 财政年份:
    2009
  • 资助金额:
    $ 1.55万
  • 项目类别:
NUTRITIONAL MANAGEMENT OF INFANTS WITH BRONCHOPULMONARY DYSPLASIA (BPD): EFFE
支气管肺发育不良 (BPD) 婴儿的营养管理:EFFE
  • 批准号:
    8166685
  • 财政年份:
    2009
  • 资助金额:
    $ 1.55万
  • 项目类别:

相似海外基金

Analysis of ceruloplasmin-related genes in pediatric patients with nonalcoholic fatty liver diseases.
儿科非酒精性脂肪肝患者血浆铜蓝蛋白相关基因分析
  • 批准号:
    19K11638
  • 财政年份:
    2019
  • 资助金额:
    $ 1.55万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Investigation on pathological significance of ceruloplasmin for development of new diagnostic methods and treatment strategies in bladder cancer
铜蓝蛋白病理学意义的研究对于开发膀胱癌新的诊断方法和治疗策略
  • 批准号:
    18K09197
  • 财政年份:
    2018
  • 资助金额:
    $ 1.55万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Understanding the reactivity of the most complex multicopper oxidase ceruloplasmin: insight into the reaction intermediates, mechanism and the roles of the additional type 1 copper sites
了解最复杂的多铜氧化酶铜蓝蛋白的反应性:深入了解反应中间体、机制和附加 1 型铜位点的作用
  • 批准号:
    9764381
  • 财政年份:
    2017
  • 资助金额:
    $ 1.55万
  • 项目类别:
Kidney Cu Homeostasis and Ceruloplasmin during Infection and Inflammation
感染和炎症期间肾脏铜稳态和铜蓝蛋白
  • 批准号:
    9752581
  • 财政年份:
    2016
  • 资助金额:
    $ 1.55万
  • 项目类别:
Kidney Cu Homeostasis and Ceruloplasmin during Infection and Inflammation
感染和炎症期间肾脏铜稳态和铜蓝蛋白
  • 批准号:
    9412383
  • 财政年份:
    2016
  • 资助金额:
    $ 1.55万
  • 项目类别:
Function of ceruloplasmin in the nervous system development
铜蓝蛋白在神经系统发育中的作用
  • 批准号:
    105730-2011
  • 财政年份:
    2015
  • 资助金额:
    $ 1.55万
  • 项目类别:
    Discovery Grants Program - Individual
Function of ceruloplasmin in the nervous system development
铜蓝蛋白在神经系统发育中的作用
  • 批准号:
    105730-2011
  • 财政年份:
    2014
  • 资助金额:
    $ 1.55万
  • 项目类别:
    Discovery Grants Program - Individual
Function of ceruloplasmin in the nervous system development
铜蓝蛋白在神经系统发育中的作用
  • 批准号:
    105730-2011
  • 财政年份:
    2013
  • 资助金额:
    $ 1.55万
  • 项目类别:
    Discovery Grants Program - Individual
Function of ceruloplasmin in the nervous system development
铜蓝蛋白在神经系统发育中的作用
  • 批准号:
    105730-2011
  • 财政年份:
    2012
  • 资助金额:
    $ 1.55万
  • 项目类别:
    Discovery Grants Program - Individual
Copper Uptake from Plasma Ceruloplasmin
从血浆铜蓝蛋白中摄取铜
  • 批准号:
    8367816
  • 财政年份:
    2012
  • 资助金额:
    $ 1.55万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了