NUEROBIOLOGY OF INCREASED VULNEABILITY TO SOCIAL STRESSORS DURING ADOLESCENCE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 使用恒河猴模型，这个项目的目的是提供一个更好的理解，如何心理社会压力，施加社会从属地位，影响大脑成熟和情感发展的女性，这是否是受多态性的基因编码的血清素再摄取转运蛋白（5 HTT），蛋白质的正常血清素神经传递和情绪。 在该项目的初始阶段，招募了第一批动物。 这些动物被嵌入野外站的大型社会群体中，并分布在每个群体的社会地位等级中。 此外，19只动物具有l/l 5 HTT基因型，20只动物具有l/s或s/s 5 HTT基因型。 今年开始的研究包括地塞米松抑制试验，以评估糖皮质激素的负反馈;使用动物佩戴的设备（Actical）测量活动;使用接近/回避试验进行情绪测试;以及使用PET进行5-羟色胺（5 HT）1A受体的神经成像。 这些研究将阐明行为、遗传和生殖成熟之间复杂的相互作用，全面了解青春期是如何成为精神疾病出现的关键时期。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using a rhesus monkey model, this project is designed to provide a better understanding of how psychosocial stress, imposed by social subordination, affects brain maturations and emotional development in females and whether this is influenced by polymorphisms in the gene that encodes the serotonin re-uptake transporter (5HTT), a protein essential for normal serotonin neurotransmission and emotionality. In this initial of the project, the first cohort of animals were recruited. These animals are embedded in large social groups at the Field Station and are distributed throughout the social status hierarchy of each group. In addition, 19 animals have the l/l 5HTT genotype and 20 animals have the l/s or s/s 5HTT genotype. Studies began this year included a dexamethasone suppression test to assess glucocorticoid negative feedback; measures of activity using a device (Actical) worn by the animal; tests of emotionality using the approach/avoidance test; and neuroimaging of the serotonin (5HT) 1A receptor using PET. These studies will elucidate the complex interplay between behavior, genetics, and reproductive maturation, providing a comprehensive understanding of how adolescence represents a critical period for the emergence of psychiatric disorders.