MEMORY MONITORING AND DECLARATIVE MEMORY IN MONKEYS: BEHAVIOR AND BRAIN

猴子的记忆监控和陈述性记忆：行为和大脑

• 批准号: 8357472
• 负责人: ROBERT L. HAMPTON
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357472
• 关键词: Age-associated memory impairment; Alzheimer' s Disease; Animal Model; Attention; Attention deficit hyperactivity disorder; Autistic Disorder; Behavior; Brain; Classification; Cognitive; Decision Making; Funding; Grant; Human; Impaired cognition; Impulse Control Disorders; Learning; Letters; Location; Memory; Monitor; Monkeys; National Center for Research Resources; Persons; Primates; Principal Investigator; Process; Publications; Reporting; Research; Research Infrastructure; Resources; Sampling; Source; Stroke; Structure; Training; United States National Institutes of Health; Work; cost; improved; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The human ability to consciously monitor the contents of memory has not been accessible to study in animal models. Because humans talk about memories that are accessible to monitoring, such memories are called declarative. In contrast, nondeclarative memories cannot be subjectively monitored, but are inferred from their influence on behavior. For example, a person who may not be able to verbally report the locations of the letters on a keyboard may nonetheless type accurately and rapidly without looking at the keys. Loss of declarative memory from stroke, Alzheimer's disease, and other brain insults severely impairs higher cognitive processes including learning, planning, and adaptive decision-making. Memory monitoring is also a form of metacognition. Impaired metacognition is implicated in autism, age-related cognitive decline, and attention and impulse control disorders such as ADHD. Animal models are needed to identify the specific brain structures involved in memory monitoring and declarative memory so that we can develop improved treatments for cognitive impairment in humans. We trained 6 monkeys in a delayed-response task and replicated all the major findings from previous research in monkey metamemory. This work is summarized in the MA thesis of Victoria Templer and is currently being prepared for publication. Twelve monkeys have been trained in the matching-to-sample and classification task necessary for the next experiments in this project. Several monkeys have begun training in the metamemory task.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 人类有意识地监控记忆内容的能力还无法在动物模型中进行研究。因为人类谈论的记忆是可以监控的，所以这样的记忆被称为陈述性的。相比之下，非陈述性记忆不能被主观监控，而是可以根据它们对行为的影响来推断。例如，一个可能无法口头报告字母在键盘上的位置的人仍然可以在不看按键的情况下准确且快速地打字。中风、阿尔茨海默病和其他脑损伤导致的陈述性记忆丧失会严重损害高级认知过程，包括学习、计划和适应性决策。 记忆监控也是元认知的一种形式。元认知受损与自闭症、与年龄相关的认知能力下降以及注意力和冲动控制障碍（例如多动症）有关。需要动物模型来识别参与记忆监控和陈述性记忆的特定大脑结构，以便我们能够开发出改善人类认知障碍的治疗方法。 我们训练了 6 只猴子进行延迟反应任务，并复制了之前猴子元记忆研究的所有主要发现。这项工作在维多利亚·坦普勒 (Victoria Templer) 的硕士论文中进行了总结，目前正在准备出版。十二只猴子已经接受了本项目下一步实验所需的样本匹配和分类任务的训练。几只猴子已经开始进行元记忆任务训练。