Liver Cancer Control Interventions for Asian Americans

描述（申请人提供）：1992-2000年期间，在所有癌症类型中，肝癌的5年生存率低于10%，其特点是发病率的年增长率最高（3.9%），而大多数其他癌症的发病率下降。肝癌的男性发病率最高的是越南人（41.8/100 000），女性发病率最高的是朝鲜人（10.0/100 000）;苗族的男性发病率为25.7/100 000，女性发病率为8.8/100 000，介于这两个群体之间。相比之下，非西班牙裔白色人的可比发病率明显较低：（男性，3.7/100，000;女性，1.5/100，000）。这些比率表明，乙型肝炎相关肝癌是影响亚裔美国人的最严重的癌症健康差异。这3个亚洲组中的每一个都将是题为“亚裔美国人肝癌控制干预”的P01的重点。“该P01由3个项目组成：#1“促进越南成年人的B型肝炎筛查”; #2“苗族成年人基于社区的B型肝炎干预”;#3“在韩国教会参加者中增加B型肝炎筛查”。“这些项目之间的协同作用体现在：所有项目都侧重于同一个因变量：提高18-64岁成年人的B型肝炎血清学检测率;使用健康行为框架;采取干预措施，比较干预和控制条件之间的效果;拥有通过NCI的亚裔美国人癌症意识研究和培训网络共同工作超过5年的研究领导者;和2个支持核心：生物统计学和方法学。我们的目标是：（1）开展以社区为基础的研究干预措施，重点是降低这3个亚裔美国人人群中乙型肝炎引起的肝癌发病率和死亡率;（2）分析各项目的数据和经验教训;（3）报告进展情况，并与NCI、种族领袖、高危人群和专业受众分享研究结果。如果这些目标和这三个项目中的每一个的具体目标都实现了，我们希望这项研究与公共卫生的相关性包括第一个基于社区的干预措施有效性的经验数据，以减少乙型肝炎引起的肝癌死亡率。

DESCRIPTION (provided by applicant): Between 1992-2000 among all cancer types, liver cancer, with its 5-year survival rate of less than 10 percent, has the distinction of having the highest annual percent increase in incidence (3.9 percent), while the incidence for the majority of other cancers declined. The highest male incidence rate of liver cancer is among Vietnamese (41.8/100,000), and the highest female incidence is among Koreans (10.0/100,000); for Hmong, the male incidence rate of 25.7/100,000 and the female incidence rate of 8.8/100,000 is intermediate between these other two groups. By contrast, the comparable incidence rates for non-Hispanic White incidence are substantially less: (male, 3.7/100,000; female, 1.5/100,000). These rates indicate that hepatitis-B related liver cancer represents the most drastic cancer health disparity affecting Asian Americans. Each of these 3 Asian groups will be the focus of this P01 entitled, "Liver Cancer Control Interventions for Asian Americans." This P01 is comprised of 3 projects: #1 "Promoting Hepatitis B Screening for Vietnamese Adults"; #2 "Community-based Hep B Interventions for Hmong Adults"; and #3 "Increasing Hep B Screening Among Korean Church Attendees." Synergy among these projects is exemplified by: having all projects focused on the same dependent variable: increasing hepatitis B serological testing rates among adults, ages 18-64; using the Health Behavior Framework; having interventions that compare effects between intervention and control conditions; having research leaders who have worked over 5 years together through the NCI's Asian American Network for Cancer Awareness Research and Training; and 2 supporting cores: Biostatistics, and Methodology. Our goals are to: (1) Conduct community-based research interventions, focused on reducing hepatitis B-induced liver cancer morbidity and mortality within these 3 Asian American populations; (2) Analyze data and lessons across projects; and (3) Report progress and share findings with the NCI, ethnic leaders, populations-at-risk and professional audiences. If these goals and the specific aims of each of these three projects are achieved, we expect the relevance of this research to public health to include the first empirically derived data on the effectiveness of community based interventions to reduce hepatitis B-induced liver cancer mortality.