BIOMARKERS OF GLUCOSE METABOLISM IN EXHALED BREATH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们提出了一种创新的方法，用于非侵入性监测血糖和相关变量，检测和量化呼气中微量挥发性有机化合物(VOCs)作为内源性代谢的生物标记物。呼出的气体代表了一套理想的潜在生物标记物，因为它们可以从几乎任何患者身上轻松且非侵入性地收集。虽然VOCs的潜力已经被认识到几十年了，并曾多次尝试利用它们进行代谢监测，但测量和分析的固有困难导致了不一致的结果，严重限制了它们的实际适用性。然而，最近分析技术的进步可能减少了这些问题，如果不能解决的话，并导致人们对这一方法重新产生兴趣，侧重于其应用的研究数量呈指数级增加。这些进展的最大贡献者是Sherwood Rowland博士和Donald Blake博士，他们是世界著名的大气化学家，也是这一应用领域的合作研究者(由于他在大气气体成分方面的发现，Rowland博士被授予1995年诺贝尔化学奖)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose an innovative approach to the field of non-invasive monitoring of blood glucose and related variables, the detection and quantification of trace amounts of Volatile Organic Compounds (VOCs) in exhaled human breath as biomarkers endogenous metabolism. Exhaled gases represent an ideal set of potential biomarkers, as they can be collected easily and non-invasively from virtually any patient. While the potential of VOCs has been recognized for decades and several attempts have been made to utilize them for metabolic monitoring, intrinsic difficulties in measurement and analysis have resulted in inconsistent results, severely limiting their practical applicability. Recent advances in analytical technology, however, may have reduced, if not solved, these problems, and resulted in renewed interest in this methodology, with an exponentially rising number of studies focusing on its applications. Among the greatest contributors to these advances are Drs. Sherwood Rowland and Donald Blake, world renowned atmospheric chemists and co-investigators in this application (for his discoveries in atmospheric gas composition, Dr. Rowland was awarded the 1995 Nobel Prize for Chemistry).