BIOMARKERS OF GLUCOSE METABOLISM IN EXHALED BREATH

呼出气中葡萄糖代谢的生物标志物

• 批准号: 8166907
• 负责人: PIETRO R GALASSETTI
• 金额: $ 0.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166907
• 关键词: Award; Biological Markers; Blood Glucose; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Detection; Exhalation; Funding; Gases; Grant; Human; Institution; Measurement; Metabolic; Metabolism; Methodology; Monitor; Nobel Prize; Patients; Problem Solving; Research; Research Personnel; Resources; Source; Technology; United States National Institutes of Health; glucose metabolism; innovation; interest; non-invasive monitor; volatile organic compound

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose an innovative approach to the field of non-invasive monitoring of blood glucose and related variables, the detection and quantification of trace amounts of Volatile Organic Compounds (VOCs) in exhaled human breath as biomarkers endogenous metabolism. Exhaled gases represent an ideal set of potential biomarkers, as they can be collected easily and non-invasively from virtually any patient. While the potential of VOCs has been recognized for decades and several attempts have been made to utilize them for metabolic monitoring, intrinsic difficulties in measurement and analysis have resulted in inconsistent results, severely limiting their practical applicability. Recent advances in analytical technology, however, may have reduced, if not solved, these problems, and resulted in renewed interest in this methodology, with an exponentially rising number of studies focusing on its applications. Among the greatest contributors to these advances are Drs. Sherwood Rowland and Donald Blake, world renowned atmospheric chemists and co-investigators in this application (for his discoveries in atmospheric gas composition, Dr. Rowland was awarded the 1995 Nobel Prize for Chemistry).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们提出了一种创新的方法，血糖和相关变量的非侵入性监测领域，检测和定量的微量挥发性有机化合物（VOCs）在呼出的人的呼吸作为内源性代谢的生物标志物。 呼出气体代表了一组理想的潜在生物标志物，因为它们可以从几乎任何患者中轻松且无创地收集。 虽然挥发性有机化合物的潜力已经被认识了几十年，并已作出了几次尝试，利用它们进行代谢监测，在测量和分析的内在困难，导致不一致的结果，严重限制了他们的实用性。 然而，分析技术的最新进展可能已经减少了这些问题，如果不是解决了这些问题的话，并导致对这种方法的新的兴趣，以指数方式增加了对其应用的研究。 这些进展的最大贡献者是舍伍德·罗兰博士和唐纳德·布莱克博士，他们是世界著名的大气化学家和这一应用的共同研究者（罗兰博士因其在大气气体成分方面的发现而获得1995年诺贝尔化学奖）。