BIOMARKERS OF GLUCOSE METABOLISM IN EXHALED BREATH

呼出气中葡萄糖代谢的生物标志物

• 批准号: 8166907
• 负责人: PIETRO R GALASSETTI
• 金额: $ 0.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166907
• 关键词: Award; Biological Markers; Blood Glucose; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Detection; Exhalation; Funding; Gases; Grant; Human; Institution; Measurement; Metabolic; Metabolism; Methodology; Monitor; Nobel Prize; Patients; Problem Solving; Research; Research Personnel; Resources; Source; Technology; United States National Institutes of Health; glucose metabolism; innovation; interest; non-invasive monitor; volatile organic compound

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose an innovative approach to the field of non-invasive monitoring of blood glucose and related variables, the detection and quantification of trace amounts of Volatile Organic Compounds (VOCs) in exhaled human breath as biomarkers endogenous metabolism. Exhaled gases represent an ideal set of potential biomarkers, as they can be collected easily and non-invasively from virtually any patient. While the potential of VOCs has been recognized for decades and several attempts have been made to utilize them for metabolic monitoring, intrinsic difficulties in measurement and analysis have resulted in inconsistent results, severely limiting their practical applicability. Recent advances in analytical technology, however, may have reduced, if not solved, these problems, and resulted in renewed interest in this methodology, with an exponentially rising number of studies focusing on its applications. Among the greatest contributors to these advances are Drs. Sherwood Rowland and Donald Blake, world renowned atmospheric chemists and co-investigators in this application (for his discoveries in atmospheric gas composition, Dr. Rowland was awarded the 1995 Nobel Prize for Chemistry).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们提出了一种创新方法，用于无创监测血糖和相关变量，检测和量化人类呼出气体中痕量挥发性有机化合物（VOC）作为内源代谢的生物标志物。 呼出气体代表了一组理想的潜在生物标志物，因为几乎可以从任何患者身上轻松、无创地收集它们。 虽然几十年来人们已经认识到 VOC 的潜力，并且已经多次尝试利用它们进行代谢监测，但测量和分析的固有困难导致结果不一致，严重限制了其实际适用性。 然而，分析技术的最新进展即使没有解决，也可能已经减少了这些问题，并导致人们对这种方法重新产生兴趣，关注其应用的研究数量呈指数级增长。 这些进步的最大贡献者之一是博士。舍伍德·罗兰 (Sherwood Rowland) 和唐纳德·布莱克 (Donald Blake) 是世界著名的大气化学家和该应用的共同研究人员（罗兰博士因在大气气体成分方面的发现而荣获 1995 年诺贝尔化学奖）。