EXERCISE AND OXIDATIVE STRESS MECHANISMS

运动和氧化应激机制

• 批准号: 8166910
• 负责人: PIETRO R GALASSETTI
• 金额: $ 1.12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166910
• 关键词: Adolescent; Adult; Antioxidants; Cardiovascular system; Child; Computer Retrieval of Information on Scientific Projects Database; Defense Mechanisms; Dyslipidemias; Elements; Exercise; Frequencies; Funding; Generations; Grant; Human; Hyperglycemia; Hypertension; Indium; Institution; Metabolic Diseases; Metabolic syndrome; Morbidity - disease rate; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Oxidative Stress; Pathogenesis; Pathology; Physical activity; Production; Reactive Oxygen Species; Regulation; Research; Research Personnel; Research Support; Resources; Role; Source; United States National Institutes of Health; cost; diet and exercise; nutrition; sound; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In a recent conference sponsored by the NICHD and NIDDK, an alarm was sounded by a group of nationally known investigators that elements of the emerging metabolic syndrome [a constellation of pathologies consisting of obesity, dyslipidemia, hypertension and hyperglycemia] (1) are appearing in increasing frequency in children and adolescents (2). If unchecked, we will witness an unprecedented level of cardiovascular and metabolic disease as this generation becomes adults, and the morbidity and cost will be staggering. While the pathogenic mechanisms of the metabolic syndrome and its elements in children are not fully understood, recent research supports a role for an imbalance between production of reactive oxygen species (ROS) and antioxidant defenses, inducing oxidative stress (3-5). This is compelling because physical activity and nutrition are among the most important naturally occurring modifiers of ROS production and antioxidant defense mechanisms in humans (6-12). In children, key mechanisms governing the interactions among exercise, diet, and the regulation of oxidative stress in the pathogenesis of the metabolic syndrome have yet to be investigated.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在最近由NICHD和NIDDK主办的一次会议上，一组全国知名的研究人员发出了警报，即新出现的代谢综合征[由肥胖、血脂异常、高血压和高血糖组成的一系列病理]（1）在儿童和青少年中出现的频率越来越高（2）。 如果不加控制，随着这一代人成年，我们将目睹前所未有的心血管和代谢疾病水平，发病率和成本将是惊人的。 虽然儿童代谢综合征及其要素的致病机制尚未完全了解，但最近的研究支持活性氧（ROS）和抗氧化防御之间的不平衡，诱导氧化应激（3-5）。 这是令人信服的，因为身体活动和营养是人体内ROS产生和抗氧化防御机制的最重要的天然调节剂之一（6-12）。 在儿童中，运动、饮食和氧化应激调节在代谢综合征发病机制中相互作用的关键机制还有待研究。