HYPOGLYCEMIA AND EXERCISE IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的具体目的是确定1型糖尿病儿童/青少年对运动的适应性糖调节反应是否减弱，这是导致这类患者低血糖发生率高的原因之一。 在1型糖尿病(T1 DM)患者的治疗中，低血糖是一个主要的临床问题。低血糖可能会扰乱日常活动，导致生命危险事件，导致胎儿损伤，改变儿童的认知功能，并对智力功能产生长期的负面影响。低血糖通常与体育锻炼有关，经常迫使患者放弃锻炼的几个好处，包括改善胰岛素敏感性和血糖控制，改善血压控制和预防心血管疾病，这些都是这些患者风险较高的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aim of this project is to determine whether in children/adolescents with Type 1 Diabetes, the adaptive glucoregulatory response to exercise is attenuated, contributing to the high incidence of hypoglycemia occurring in this group of patients. In the management of patients with Type 1 diabetes mellitus (T1DM), hypoglycemia is a major clinical problem. Hypoglycemia may disrupt daily activities, cause life-threatening events, induce fetal damage, alter cognitive function in children, and exert long-term negative effects on intellectual function. Hypoglycemia often occurs in association with physical exercise, often forcing patients to renounce several beneficial effects of exercise, including improved insulin sensitivity and glycemic control, and improved control of blood pressure and prevention of cardiovascular disease, for which these patients are at elevated risk.