Inflammatory Biomarkers in Pediatric Obesity and Diabetes: Research and Mentoring

儿童肥胖和糖尿病的炎症生物标志物：研究和指导

• 批准号: 8531910
• 负责人: PIETRO R GALASSETTI
• 金额: $ 14.73万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531910
• 关键词: Adolescent; American; Area; Award; Biochemical; Biological Markers; Blood; Blood specimen; Breath Tests; California; Carbohydrates; Cardiovascular system; Child; Childhood; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Commit; Development; Diabetes Mellitus; Doctor of Philosophy; Early Diagnosis; Evolution; Exercise; Exhalation; Extramural Activities; Faculty; Fatty acid glycerol esters; Foundations; Free Radicals; Funding; Funding Agency; Gases; Gender; Glucose; Grant; Human; Hyperglycemia; Hyperinsulinism; Hyperlipidemia; Hypoglycemia; Individual; Inflammation; Inflammatory; Ingestion; Institutes; Insulin; Insulin-Dependent Diabetes Mellitus; International; Internships; Journals; Laboratories; Lipids; Measurement; Measures; Medical Students; Mentors; Mentorship; Metabolic syndrome; Metabolism; National Institute of Child Health and Human Development; Nature; Neonatology; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Obesity; Oxidative Stress; Paper; Pathogenesis; Physical Fitness; Physiological; Placebos; Plasma; Population; Postdoctoral Fellow; Publishing; Publishing Peer Reviews; Regulation; Research; Research Activity; Research Personnel; Research Project Grants; Role; Sampling; Scholarship; Services; Structure; Techniques; Testing; Time; Training Programs; Translational Research; United States National Institutes of Health; Universities; Wages; abstracting; base; biological adaptation to stress; career; diabetic; diabetic patient; graduate student; improved; inflammatory marker; middle school; neutrophil; novel; obesity in children; patient oriented; patient oriented research; pediatric pharmacology; professor; programs; public health relevance; research study; response; screening; volatile organic compound

DESCRIPTION (provided by applicant): Pietro Galassetti, MD PhD, is an Associate Professor in the Departments of Pediatric and Pharmacology of the University of California, Irvine, where he also serves as Director of the Metabolism and Bionutrition Core at the Institute for Clinical and Translational Science (ICTS, formerly GCRC). He has been involved in Patient Oriented Research for the last 20 years, and currently is PI on 2 extramural grants (including an NIH RO1), focused on projects with the common theme of defining the biochemical mechanisms underlying the early development of complications in dysmetabolic states, such as obesity, metabolic syndrome, type 1 (T1DM) and type 2 diabetes (T2DM). His current main specific research topics are: a) The development of a non-invasive technique for the measurement of plasma glucose, insulin and lipids through integrated analysis of exhaled volatile organic compounds; b) The definition of inflammatory and oxidative stress mechanisms during exercise in children with obesity and metabolic syndrome. These projects are fully patient-oriented and translational in nature. Maintaining and improving adequate research funding for the evolution of these projects will be challenging in coming years. With this application, support for 50% of Dr. Galassetti's professional effort is requested, of which half, or 25% of his total time, will be devoted to completing novel, exploratory experiments in the 2 research areas outlined above, aimed at facilitating the acquisition of additional research funding. Dr. Galassetti has published extensively on translational research topics in high-impact journals (35 published peer reviewed papers in the last 5 years only, out of a total of 78); he acts as reviewer to over twenty scientific journals, several grant funding agencies (NIH, JDRF, and other national and international foundations). A large share of Dr. Galassetti's time is taken up by mentoring activities, These include: a) direct mentoring of UCI residents, fellows, medical and graduate students who participate in Dr. Galassetti's research projects; b) mentoring of junior faculty who are trying to develop independent research lines; c) mentoring of junior investigators involved in clinical-translational projects with other PIs, requesting Dr. Galassetti's expertise; d) mentoring through structured UCI mechanisms, such as the Bio 199 Clinical Research Course, Internships for the UCI Clinical Trial Courses, the UCI Mentored Medical Student Clinical Research Program, the Neonatology Fellows Scholarship Oversight Committee, etc. Many of his trainees co-authored abstracts and papers based on recent study results, and several have won regional and national research awards while under his mentorship. The remaining 25% of the requested salary support will therefore be devoted to the continuation and expansion of these mentoring activities. In summary, Dr. Galassetti is fully committed to a career in Patient Oriented Research. This award will allow to considerably reduce his current onerous amount of administrative and service duties, and proportionally increase protected time dedicated to mentoring and research activities in translational science. PUBLIC HEALTH RELEVANCE: Pietro Galassetti, MD PhD, is a researcher at the University of California, Irvine, and has been involved in Patient Oriented Research for 20 years. He has 2 funded research projects, with the common theme to define the early development of complications of obesity and diabetes: a) The development of a novel technique to measure glucose, insulin and fat from human breath (i.e. not requiring a blood sample); b) The study of the damage from inflammation and free radicals during exercise in obese children. Both projects are clear examples of patient-oriented research. With this application, 50% salary support is requested for Dr. Galassetti's; of which 25% will be devoted to novel, exploratory experiments that will expand current projects and facilitate acquisition of additional research funding. Dr. Galassetti has published extensively in high-level scientific journals (35 papers in the last 5 years, out of a total of 78). A large share of Dr. Galassetti's time is taken up by mentoring activities, for UCI clinical residents and fellows, post-doctoral fellows, medical and graduate students. The remaining 25% of the requested salary support will be devoted to the continuation and expansion of these mentoring activities. In summary, Dr. Galassetti is fully committed to a career in Patient Oriented Research, and this award will result in reduced administrative duties and more protected time, increasing his current levels of mentoring and research activities.

描述（由申请人提供）：Pietro Galassetti，医学博士，博士，是加州大学欧文分校儿科和药理学系的副教授，同时担任临床和转化科学研究所（ICTS，前身为 GCRC）代谢和生物营养核心主任。在过去的 20 年里，他一直参与以患者为导向的研究，目前是 2 项校外资助（包括 NIH RO1）的 PI​​，重点关注共同主题的项目，即确定代谢失调状态并发症早期发展的生化机制，例如肥胖、代谢综合征、1 型 (T1DM) 和 2 型糖尿病 (T2DM)。他目前的主要具体研究课题是： a) 通过呼出的挥发性有机化合物的综合分析，开发一种无创测量血浆葡萄糖、胰岛素和血脂的技术； b) 肥胖和代谢综合征儿童运动期间炎症和氧化应激机制的定义。这些项目本质上是完全以患者为导向和转化性的。未来几年，为这些项目的发展维持和增加足够的研究经费将是一项挑战。通过此申请，需要支持 Galassetti 博士 50% 的专业工作，其中一半（即总时间的 25%）将用于完成上述 2 个研究领域的新颖的探索性实验，旨在促进获得额外的研究资金。 Galassetti 博士在高影响力期刊上发表了大量关于转化研究主题的文章（仅在过去 5 年发表了 35 篇同行评审论文，总共 78 篇）；他担任 20 多种科学期刊、多家资助机构（NIH、JDRF 以及其他国家和国际基金会）的审稿人。 Galassetti 博士的大部分时间都花在指导活动上，其中包括： a) 直接指导参与 Galassetti 博士研究项目的 UCI 住院医生、研究员、医学生和研究生； b）对试图发展独立研究方向的初级教师进行指导； c) 与其他 PI 一起指导参与临床转化项目的初级研究者，请求 Galassetti 博士的专业知识； d) 通过结构化的 UCI 机制进行指导，例如 Bio 199 临床研究课程、UCI 临床试验课程实习、UCI 指导医学生临床研究计划、新生儿研究员奖学金监督委员会等。他的许多学员根据最近的研究结果共同撰写了摘要和论文，其中一些学员在他的指导下获得了地区和国家研究奖项。因此，剩余 25% 的薪资支持将用于继续和扩大这些指导活动。总之，加拉塞蒂博士完全致力于以患者为导向的研究事业。该奖项将大大减少他目前繁重的行政和服务职责，并按比例增加专门用于转化科学指导和研究活动的受保护时间。 公共卫生相关性：Pietro Galassetti 博士是加州大学欧文分校的研究员，从事以患者为导向的研究已有 20 年。他有 2 个受资助的研究项目，其共同主题是定义肥胖和糖尿病并发症的早期发展： a) 开发一种新技术来测量人类呼吸中的葡萄糖、胰岛素和脂肪（即不需要血液样本）； b) 研究肥胖儿童运动过程中炎症和自由基造成的损害。这两个项目都是以患者为中心的研究的明显例子。通过此申请，要求为 Galassetti 博士提供 50% 的工资支持；其中 25% 将用于新颖的探索性实验，以扩大现有项目并促进获得额外的研究资金。 Galassetti 博士在高水平科学期刊上发表了大量文章（过去 5 年发表了 35 篇论文，总共 78 篇论文）。 Galassetti 博士的大部分时间都花在为 UCI 临床住院医师和研究员、博士后研究员、医学生和研究生提供指导活动上。所要求的薪资支持的其余 25% 将专门用于继续和扩大这些指导活动。总之，Galassetti 博士完全致力于以患者为导向的研究事业，该奖项将减少行政职责和更多受保护的时间，从而提高他目前的指导和研究活动水平。