Inflammatory Biomarkers in Pediatric Obesity and Diabetes: Research and Mentoring

儿童肥胖和糖尿病的炎症生物标志物：研究和指导

• 批准号: 7989293
• 负责人: PIETRO R GALASSETTI
• 金额: $ 15.33万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7989293
• 关键词: Adolescent; American; Area; Award; Biochemical; Biological Markers; Blood; Blood specimen; Breath Tests; California; Carbohydrates; Cardiovascular system; Child; Childhood; Clinical; Clinical Research; Clinical Trials; Commit; Development; Diabetes Mellitus; Doctor of Philosophy; Early Diagnosis; Evolution; Exercise; Exhalation; Extramural Activities; Faculty; Fatty acid glycerol esters; Foundations; Free Radicals; Funding; Funding Agency; Gases; Gender; Glucose; Grant; Human; Hyperglycemia; Hyperinsulinism; Hyperlipidemia; Hypoglycemia; Individual; Inflammation; Inflammatory; Ingestion; Institutes; Insulin; Insulin-Dependent Diabetes Mellitus; International; Internships; Journals; Laboratories; Lipids; Measurement; Measures; Medical; Medical Students; Mentors; Mentorship; Metabolic syndrome; Metabolism; National Institute of Child Health and Human Development; Nature; Neonatology; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Obesity; Oxidative Stress; Paper; Pathogenesis; Physical Fitness; Physiological; Placebos; Plasma; Population; Postdoctoral Fellow; Publishing; Publishing Peer Reviews; Regulation; Research; Research Activity; Research Personnel; Research Project Grants; Role; Sampling; Scholarship; Screening procedure; Services; Structure; Techniques; Testing; Time; Training Programs; Translational Research; United States National Institutes of Health; Universities; Wages; abstracting; base; biological adaptation to stress; career; diabetic; diabetic patient; graduate student; improved; inflammatory marker; middle school; neutrophil; novel; patient oriented; patient oriented research; pediatric pharmacology; professor; programs; public health relevance; research study; response; volatile organic compound

DESCRIPTION (provided by applicant): Pietro Galassetti, MD PhD, is an Associate Professor in the Departments of Pediatric and Pharmacology of the University of California, Irvine, where he also serves as Director of the Metabolism and Bionutrition Core at the Institute for Clinical and Translational Science (ICTS, formerly GCRC). He has been involved in Patient Oriented Research for the last 20 years, and currently is PI on 2 extramural grants (including an NIH RO1), focused on projects with the common theme of defining the biochemical mechanisms underlying the early development of complications in dysmetabolic states, such as obesity, metabolic syndrome, type 1 (T1DM) and type 2 diabetes (T2DM). His current main specific research topics are: a) The development of a non-invasive technique for the measurement of plasma glucose, insulin and lipids through integrated analysis of exhaled volatile organic compounds; b) The definition of inflammatory and oxidative stress mechanisms during exercise in children with obesity and metabolic syndrome. These projects are fully patient-oriented and translational in nature. Maintaining and improving adequate research funding for the evolution of these projects will be challenging in coming years. With this application, support for 50% of Dr. Galassetti's professional effort is requested, of which half, or 25% of his total time, will be devoted to completing novel, exploratory experiments in the 2 research areas outlined above, aimed at facilitating the acquisition of additional research funding. Dr. Galassetti has published extensively on translational research topics in high-impact journals (35 published peer reviewed papers in the last 5 years only, out of a total of 78); he acts as reviewer to over twenty scientific journals, several grant funding agencies (NIH, JDRF, and other national and international foundations). A large share of Dr. Galassetti's time is taken up by mentoring activities, These include: a) direct mentoring of UCI residents, fellows, medical and graduate students who participate in Dr. Galassetti's research projects; b) mentoring of junior faculty who are trying to develop independent research lines; c) mentoring of junior investigators involved in clinical-translational projects with other PIs, requesting Dr. Galassetti's expertise; d) mentoring through structured UCI mechanisms, such as the Bio 199 Clinical Research Course, Internships for the UCI Clinical Trial Courses, the UCI Mentored Medical Student Clinical Research Program, the Neonatology Fellows Scholarship Oversight Committee, etc. Many of his trainees co-authored abstracts and papers based on recent study results, and several have won regional and national research awards while under his mentorship. The remaining 25% of the requested salary support will therefore be devoted to the continuation and expansion of these mentoring activities. In summary, Dr. Galassetti is fully committed to a career in Patient Oriented Research. This award will allow to considerably reduce his current onerous amount of administrative and service duties, and proportionally increase protected time dedicated to mentoring and research activities in translational science. PUBLIC HEALTH RELEVANCE: Pietro Galassetti, MD PhD, is a researcher at the University of California, Irvine, and has been involved in Patient Oriented Research for 20 years. He has 2 funded research projects, with the common theme to define the early development of complications of obesity and diabetes: a) The development of a novel technique to measure glucose, insulin and fat from human breath (i.e. not requiring a blood sample); b) The study of the damage from inflammation and free radicals during exercise in obese children. Both projects are clear examples of patient-oriented research. With this application, 50% salary support is requested for Dr. Galassetti's; of which 25% will be devoted to novel, exploratory experiments that will expand current projects and facilitate acquisition of additional research funding. Dr. Galassetti has published extensively in high-level scientific journals (35 papers in the last 5 years, out of a total of 78). A large share of Dr. Galassetti's time is taken up by mentoring activities, for UCI clinical residents and fellows, post-doctoral fellows, medical and graduate students. The remaining 25% of the requested salary support will be devoted to the continuation and expansion of these mentoring activities. In summary, Dr. Galassetti is fully committed to a career in Patient Oriented Research, and this award will result in reduced administrative duties and more protected time, increasing his current levels of mentoring and research activities.

描述（由申请人提供）：Pietro Galassetti，医学博士和哲学博士，是加州大学欧文分校儿科和药理学系的副教授，他还担任临床和转化科学研究所（ICTS，前身为GCRC）代谢和生物营养核心主任。在过去的20年里，他一直参与以患者为导向的研究，目前是2个校外资助的赠款（包括NIH RO 1），专注于定义代谢异常状态早期并发症发展的生化机制的共同主题的项目，如肥胖，代谢综合征，1型（T1 DM）和2型糖尿病（T2 DM）。他目前的主要具体研究课题是：a）通过对呼出的挥发性有机化合物进行综合分析，开发用于测量血糖、胰岛素和血脂的非侵入性技术; B）肥胖和代谢综合征儿童运动期间炎症和氧化应激机制的定义。这些项目是完全以病人为导向和翻译的性质。在未来几年里，为这些项目的发展维持和增加足够的研究资金将是一项挑战。Galassetti博士的50%的专业工作需要支持，其中一半，或他的总时间的25%，将致力于完成上述2个研究领域的新颖，探索性实验，旨在促进获得额外的研究资金。Galassetti博士在高影响力期刊上发表了大量关于翻译研究主题的文章（仅在过去5年中发表了35篇同行评审论文，总共78篇）;他担任二十多个科学期刊的评审员，几个赠款资助机构（NIH，JDRF和其他国家和国际基金会）。Galassetti博士的大部分时间都被指导活动所占用，这些活动包括：a）直接指导参加Galassetti博士研究项目的UCI居民，研究员，医学生和研究生; B）指导试图开发独立研究路线的初级教师; c）指导与其他PI一起参与临床转化项目的初级研究者，要求Galassetti博士提供专业知识; d）通过UCI结构化机制进行指导，例如生物199临床研究课程，UCI临床试验课程实习，UCI指导医学生临床研究计划，新生儿科研究员奖学金监督委员会等。在他的指导下，有几个人获得了地区和国家研究奖。因此，所要求的薪金支助的其余25%将用于继续和扩大这些辅导活动。Galassetti博士完全致力于以患者为导向的研究事业。该奖项将大大减少他目前繁重的行政和服务职责，并按比例增加专门用于指导和研究活动的时间。 公共卫生相关性：Pietro Galassetti，医学博士，是加州大学欧文分校的研究员，从事面向患者的研究已有20年。他有两个资助的研究项目，共同的主题是定义肥胖和糖尿病并发症的早期发展：a）开发一种新技术来测量人体呼吸中的葡萄糖，胰岛素和脂肪（即不需要血液样本）; B）研究肥胖儿童运动期间炎症和自由基的损害。这两个项目都是以病人为导向的研究的明显例子。Galassetti博士申请50%的工资支持，其中25%将用于新的探索性实验，以扩大现有项目并促进获得额外的研究资金。Galassetti博士在高水平的科学期刊上发表了大量文章（在过去5年中发表了35篇论文，总共78篇）。Galassetti博士的大部分时间都用于指导UCI临床住院医师和研究员、博士后研究员、医学和研究生的活动。其余25%的薪金支助将用于继续和扩大这些辅导活动。Galassetti博士完全致力于以患者为导向的研究事业，这一奖项将减少行政职责和更多的保护时间，提高他目前的指导和研究活动水平。