IBR COBRE ADMINISTRATIVE CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Cobre的目标是改变夏威夷大学M分校约翰·A·伯恩斯医学院(JABSOM)现有的生物发生研究所(IBR)NOA(UH-MNOA)成为一家跨学科的生殖生物学转化型研究所。IBR是由夏威夷州于1999年建立的。其成立的基本理念是延续国家科学院院士柳马内隆三博士开创的生殖生物学研究遗产。他的团队在生殖生物学方面取得了重大突破，包括卵胞浆内单精子注射(ICSI)的发展、哺乳动物体外受精(IVF)的基本原理、哺乳动物重复克隆的首次演示以及ICSI介导的转基因小鼠。IBR的研究重点在于哺乳动物胚胎发生的早期分子事件及其对后期发育阶段的影响。Cobre支持五名初级研究人员，他们的研究专长与IBR的研究重点直接相关，并创造了一个转基因小鼠核心。通过与太平洋试管受精研究所和妇产科临床部的合作，我们将支持旨在促进生殖科学并减少儿童不孕不育和出生缺陷的翻译项目。我们寻求通过以下具体目标实现这些目标：1)IBR Cobre将为UH-M的基础设施做出贡献2)IBR Cobre将支持有才华的初级教员走向独立，因为他们进行创新的基础、临床和翻译研究，旨在产生与生殖健康相关的数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of COBRE is to transform the existing Institute for Biogenesis Research (IBR) at the John A. Burns School of Medicine (JABSOM) in the University of Hawaii at M
noa (UH-M
noa) into an interdisciplinary, translational research institute for reproductive biology. The IBR was established in 1999 by the State of Hawaii. Its founding rationale was to continue the legacy of reproductive biology research pioneered by National Academy member Dr. Ryuzo Yanagimachi. His team produced major breakthroughs in reproductive biology, including the development of intracytoplasmic sperm injection (ICSI), the principles underlying in vitro fertilization (IVF) in mammals, the first demonstration of repetitive mammalian cloning, and ICSI-mediated transgenic mice. The IBR's research focus lies in early molecular events in mammalian embryogenesis and their effects on later stages of development. This COBRE supports five junior investigators whose research expertise is directly related to the IBR's research focus, and the creation of a Transgenic Mouse Core. Through partnership with the Pacific IVF Institute and the clinical Department of Obstetrics and Gynecology, we will support translational projects designed to advance the science of reproduction and reduce both infertility and birth defects for children. We seek to accomplish these objectives through the following specific aims: 1) the IBR COBRE will contribute to infrastructure at UH-M
noa by enhancing Core resources available for investigators across campus, and 2) the IBR COBRE will support talented junior faculty toward independence as they conduct innovative basic, clinical and translational studies designed to produce data relevant to reproductive health.