IBR COBRE ADMINISTRATIVE CORE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 COBRE的目标是改造现有的生物发生研究所（IBR）在约翰A。美国夏威夷大学伯恩斯医学院
noa（UH-M
noa）成为一个跨学科的生殖生物学转化研究所。 IBR于1999年由夏威夷州建立。其成立的理由是继续由国家科学院成员Ryuzo Yanagimachi博士开创的生殖生物学研究遗产。他的团队在生殖生物学方面取得了重大突破，包括胞浆内单精子注射（ICSI）的发展，哺乳动物体外受精（IVF）的基本原理，重复哺乳动物克隆的首次演示，以及ICSI介导的转基因小鼠。 IBR的研究重点在于哺乳动物胚胎发生的早期分子事件及其对后期发育的影响。 该COBRE支持五名初级研究人员，他们的研究专长与IBR的研究重点直接相关，并创建转基因小鼠核心。通过与太平洋试管婴儿研究所和妇产科临床部门的合作，我们将支持旨在促进生殖科学和减少不孕症和儿童出生缺陷的转化项目。我们寻求通过以下具体目标来实现这些目标：1）IBR COBRE将有助于UH-M的基础设施
noa通过增强校园内研究人员的核心资源，2）IBR COBRE将支持有才华的初级教师走向独立，因为他们进行创新的基础，临床和翻译研究，旨在产生与生殖健康相关的数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of COBRE is to transform the existing Institute for Biogenesis Research (IBR) at the John A. Burns School of Medicine (JABSOM) in the University of Hawaii at M
noa (UH-M
noa) into an interdisciplinary, translational research institute for reproductive biology. The IBR was established in 1999 by the State of Hawaii. Its founding rationale was to continue the legacy of reproductive biology research pioneered by National Academy member Dr. Ryuzo Yanagimachi. His team produced major breakthroughs in reproductive biology, including the development of intracytoplasmic sperm injection (ICSI), the principles underlying in vitro fertilization (IVF) in mammals, the first demonstration of repetitive mammalian cloning, and ICSI-mediated transgenic mice. The IBR's research focus lies in early molecular events in mammalian embryogenesis and their effects on later stages of development. This COBRE supports five junior investigators whose research expertise is directly related to the IBR's research focus, and the creation of a Transgenic Mouse Core. Through partnership with the Pacific IVF Institute and the clinical Department of Obstetrics and Gynecology, we will support translational projects designed to advance the science of reproduction and reduce both infertility and birth defects for children. We seek to accomplish these objectives through the following specific aims: 1) the IBR COBRE will contribute to infrastructure at UH-M
noa by enhancing Core resources available for investigators across campus, and 2) the IBR COBRE will support talented junior faculty toward independence as they conduct innovative basic, clinical and translational studies designed to produce data relevant to reproductive health.