Translational Pilot Project Program

项目摘要/摘要-翻译试点项目计划 在IDEA的资助下，生物发生研究所(IBR)蓬勃发展，从一个小的、新的 由三名教员组成的机构成为世界著名的发育和生殖生物学中心 四个不同系的十四名教员。IBR-COBRE的总体目标是加强 加快科学发现步伐，提高研究生产率和优化 争取外部资金的竞争力。该中心在哺乳动物的基础和应用研究方面表现出色。 发育和生殖生物学，以及一个明显的领域，将提供一个明确的机会 增长和竞争力的提高是一项转化性研究。在过去的三年里，IBR-Cobre 通过与以下合作伙伴合作，实现了开发其重点的翻译研究部门的主要战略目标 产科、妇科和妇女健康学部。妇产科)。该部门。Ob/Gyn的是 医学院最成功的临床科室，最近积累了800多万美元 为它的学术发展提供捐赠。IBR与妇产科的合作伙伴关系由 任命IBR-Cobre Pi为部门研究部主任。妇产科11月， 2014年。他管理着200万美元的夏尔马捐赠基金，指定用于该部门的研究。另外， 部门妇产科最近招聘了一位内科科学家，曼恩-让·李博士，他是 母体胎儿医学。李博士在主要的IBR设施中获得了实验室空间，促进了合作 在IBR和妇产科之间。IBR的另外两名成员M.Ward博士和Garmire博士是兼职教员 在系里。妇产科。第一阶段Cobre项目是一项与DEPT合作的临床研究。妇产科 研究肥胖母亲所生子女癌症增加的机制。这种伙伴关系已经 导致R01检查患病胎盘的表观遗传学变化。因此，IBR开发了一种 与最接近其研究重点的临床科室建立牢固和成功的合作伙伴关系。同相 第三，中心将利用其与部门的合作伙伴关系。OB/GYN将开发和实施灵活的翻译 研究先导项目计划，旨在开发翻译研究项目，目标是 发展中心的新分支，扩大其竞争力。该计划将是灵活的，有两种类型 需要IBR和妇产科教员合作的奖项和翻译研究试点项目， 并提供资金，帮助研究人员弥补资金缺口。这些程序旨在开发 转化性研究项目，引导成熟的研究人员度过资金缺口，并提供灵活、 和运行机制，以帮助IBR中已经具有竞争力的教师。

PROJECT SUMMARY/ABSTRACT – Translational Pilot Project Program With IDeA funding, the Institute for Biogenesis Research (IBR) has thrived, developing from a small, newly formed institution with three faculty to a world renown center for developmental and reproductive biology with fourteen faculty in four different departments. The overall objective of the IBR-COBRE is to enhance the conditions that accelerate the pace of scientific discovery, heighten research productivity and optimize competitiveness for extramural funding. The center has excelled in basic and applied research in mammalian developmental and reproductive biology, and one obvious arena which would provide a clear opportunity for growth and increased competitiveness is translational research. Over the past three years, the IBR-COBRE has pursued a primary strategic goal of developing a translational research arm of its focus by partnering with the Department of Obstetrics, Gynecology & Women's Health (Dept. Ob/Gyn). The Dept. of Ob/Gyn is one of the most successful clinical departments at the medical school, that has recently accrued more than $8 million in endowments for its academic development. The IBR's partnership with Ob/Gyn is facilitated by the appointment of the IBR-COBRE PI as the Chief of the Division of Research in the Dept. Ob/Gyn in November, 2014. He manages the $2 million Sharma Endowment designated for research in the department. Also, the Dept. of Ob/Gyn recently recruited a physician-scientist, Dr. Men-Jean Lee, who is Chief of the Division of Maternal Fetal Medicine. Dr. Lee was given lab space in the main IBR facility, facilitating collaborations between the IBR and Ob/Gyn. Two other members of the IBR, Drs. M. Ward, and Garmire, are adjunct faculty in the Dept. Ob/Gyn. One Phase II COBRE project is a clinical study that partners with Dept. Ob/Gyn examining the mechanism of increased cancer in children born to obese mothers. This partnership already resulted in an R01 examining epigenetic changes in diseased placenta. The IBR has therefore developed a strong and successful partnership with the clinical department that is closest to its focus of research. In Phase III, the center will leverage its partnership with Dept. Ob/Gyn to develop and implement a flexible Translational Research Pilot Project Program that is targeted to developing translational research projects, with the goal of developing a new arm of the center expanding its competitiveness. The program will be flexible, with two types of awards, translational research pilot projects that require collaborations between IBR and Ob/Gyn faculty, and bridging funds to assist researchers bridge funding gaps. The programs are designed to develop translational research projects, steer mature investigators through funding lapses, and to provide a flexible, and functional mechanism to assist already competitive faculty in the IBR.