IBR-COBRE Phase III

项目总结/摘要-整体组件 2015年在美国出生的大约7万名婴儿是通过人工生殖技术受孕的。 技术（ART），涉及两种技术之一：体外受精（IVF），其中精子 在体外使卵子受精，或将精子注射到卵子中的胞浆内精子注射（ICSI） 使用显微操作。ART在全球范围内的迅速崛起，以及程序的持续发展 由ART诊所雇用，要求研究跟上步伐，以确保ART的安全性，并提高 生殖健康。从2000年只有三名教师开始，从2008年开始提供COBRE支持，IBR 发展到14个全职教师在四个部门，在约翰A。伯恩斯医学院（JABSOM）， 夏威夷大学马诺阿分校（UHM）。在这14个项目中，COBRE第一和第二阶段支持了10个项目， 其中两项获得了独立的NIH R系列资助。COBRE资助的直接结果是IBR已经 成为国际公认的生殖生物学卓越研究中心， 世界上最好的小鼠配子操作中心（ICSI和IVF）。在第一阶段，IBR招募了 五个新的教师，建立它作为一个生殖生物学研究所，并吸引了几个国家和 国际实习生。在第二阶段，第一阶段的项目领导人成为导师和核心主任， 维护自己的实验室。另外招募了五名教师，带来了表观遗传学方面的专业知识， 生物信息学、基因编辑和器官开发，我们还与 妇产科和妇女健康系（妇产科）。经过十年的支持，该中心是 现在有竞争力的几个赠款机会，我们将在第三阶段追求。COBRE第三阶段的目标是 维持IBR COBRE作为一个世界级的基础和卓越的转化科学中心， 生殖生物学这将通过两个具体目标来实现。具体目标1：扩大和 使COBRE研究核心的专业知识多样化。核心用户群的增长和多样化， 精简核心业务，加强核心收入流，将使 加快科学发现的步伐，提高研究生产力， 竞争力的外部资金。具体目标2：制定和实施翻译试点项目 程序.我们将利用与部门的强有力的伙伴关系。Ob/Gyn开发一种新的平移臂， 研究IBR。在第三阶段COBRE结束时，我们设想每个核心都将完全或 基本上是自我维持的，通过一个协调的补充帐户计划、校外赠款、战略 投资和慈善事业，IBR将成功完成翻译的发展， 研究臂通过一个新的试点项目计划的实施。

PROJECT SUMMARY/ABSTRACT – Overall Component Approximately 70,000 babies born in the U.S. in 2015 were conceived by artificial reproductive technologies (ART), which involves one of two techniques: in vitro fertilization (IVF) in which the sperm fertilizes the egg in vitro, or intracytoplasmic sperm injection (ICSI) in which the sperm is injected into the egg using micromanipulation. The rapid rise in ART world wide, and continued developments of the procedures employed by ART clinics, requires that research keeps pace to ensure the safety of ART and to improve reproductive health. Starting with just three faculty in 2000, with COBRE support starting in 2008, the IBR has grown to 14 full-time faculty in four departments, within the John A. Burns School of Medicine (JABSOM), of the University of Hawaii at Manoa (UHM). Of these 14, the COBRE Phases I and II supported 10, and all but two have obtained independent NIH R-series funding. The direct result of COBRE funding is that the IBR has emerged as an internationally recognized center of research excellence for reproductive biology and one of the best centers in the world for mouse gamete manipulation (ICSI and IVF). During Phase I, the IBR recruited five new faculty, establishing it as a reproductive biology research institute and attracting several national and international trainees. During Phase II, the Phase I project leaders became mentors and core directors while maintaining their own labs. Five additional faculty were recruited, bringing expertise in epigenetics, bioinformatics, gene editing and organ development, and we also established a close partnership with the Department of Obstetrics, Gynecology and Women's Health (Ob/Gyn). After ten years of support, the center is now competitive for several grant opportunities that we will pursue in Phase III. Phase III COBRE objective is to sustain the IBR COBRE as a world-class basic and translational science center of excellence in reproductive biology. This will be accomplished through two Specific Aims. Specific Aim 1: Expand and diversify the expertise of the COBRE research cores. Growing and diversifying the core user base, enhancing and streamlining core operations, and strengthening the core revenue streams will result in the sustainability of the cores and accelerate the pace of scientific discovery, heighten research productivity and increase competitiveness for extramural funding. Specific Aim 2: Develop and implement a Translational Pilot Project Program. We will leverage a strong partnership with the Dept. of Ob/Gyn to develop a new translational arm of research for the IBR. At the end of the Phase III COBRE, we envision that each of the cores will be fully or largely self-sustained, through a coordinated plan of recharge accounts, extramural grants, strategic investments and philanthropy, and that a the IBR will have successfully completed development of translational research arm through a novel implementation of the pilot projects program.