Translational Pilot Project Program

转化试点项目计划

• 批准号: 10656279
• 负责人: WILLIAM S WARD
• 金额: $ 36.09万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-13 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656279
• 关键词: Acceleration; Applications Grants; Applied Research; Appointment; Award; Basic Science; Biogenesis; Center for Translational Science Activities; Centers of Research Excellence; Cessation of life; Clinical; Clinical Research; Collaborations; Development; Developmental Biology; Discipline of obstetrics; Endowment; Epigenetic Process; Extramural Activities; Faculty; Funding; Future; Goals; Growth; Gynecology; Institution; Investments; Malignant Childhood Neoplasm; Maternal-fetal medicine; Medical; Mentors; Phase; Physicians; Pilot Projects; Placenta Diseases; Productivity; Reproductive Biology; Research; Research Personnel; Research Project Grants; Scientist; Series; Teacher Professional Development; Techniques; Translational Research; Translations; United States National Institutes of Health; Women' s Health; arm; career development; clinical application; design; faculty mentor; flexibility; innovation; medical schools; member; men; obese mothers; programs; recruit; research facility; safety assessment; success; ward

PROJECT SUMMARY/ABSTRACT – Translational Pilot Project Program With IDeA funding, the Institute for Biogenesis Research (IBR) has thrived, developing from a small, newly formed institution with three faculty to a world renown center for developmental and reproductive biology with fourteen faculty in four different departments. The overall objective of the IBR-COBRE is to enhance the conditions that accelerate the pace of scientific discovery, heighten research productivity and optimize competitiveness for extramural funding. The center has excelled in basic and applied research in mammalian developmental and reproductive biology, and one obvious arena which would provide a clear opportunity for growth and increased competitiveness is translational research. Over the past three years, the IBR-COBRE has pursued a primary strategic goal of developing a translational research arm of its focus by partnering with the Department of Obstetrics, Gynecology & Women's Health (Dept. Ob/Gyn). The Dept. of Ob/Gyn is one of the most successful clinical departments at the medical school, that has recently accrued more than $8 million in endowments for its academic development. The IBR's partnership with Ob/Gyn is facilitated by the appointment of the IBR-COBRE PI as the Chief of the Division of Research in the Dept. Ob/Gyn in November, 2014. He manages the $2 million Sharma Endowment designated for research in the department. Also, the Dept. of Ob/Gyn recently recruited a physician-scientist, Dr. Men-Jean Lee, who is Chief of the Division of Maternal Fetal Medicine. Dr. Lee was given lab space in the main IBR facility, facilitating collaborations between the IBR and Ob/Gyn. Two other members of the IBR, Drs. M. Ward, and Garmire, are adjunct faculty in the Dept. Ob/Gyn. One Phase II COBRE project is a clinical study that partners with Dept. Ob/Gyn examining the mechanism of increased cancer in children born to obese mothers. This partnership already resulted in an R01 examining epigenetic changes in diseased placenta. The IBR has therefore developed a strong and successful partnership with the clinical department that is closest to its focus of research. In Phase III, the center will leverage its partnership with Dept. Ob/Gyn to develop and implement a flexible Translational Research Pilot Project Program that is targeted to developing translational research projects, with the goal of developing a new arm of the center expanding its competitiveness. The program will be flexible, with two types of awards, translational research pilot projects that require collaborations between IBR and Ob/Gyn faculty, and bridging funds to assist researchers bridge funding gaps. The programs are designed to develop translational research projects, steer mature investigators through funding lapses, and to provide a flexible, and functional mechanism to assist already competitive faculty in the IBR.

项目概要/摘要-翻译试点项目计划 在IDEA的资助下，生物发生研究所（IBR）蓬勃发展，从一个小型的，新的 成立了一个拥有三名教员的机构，成为世界著名的发育和生殖生物学中心， 四个不同部门的十四名教师。IBR-COBRE的总体目标是加强 加速科学发现的步伐，提高研究生产力和优化的条件 竞争力的外部资金。该中心在哺乳动物的基础和应用研究方面表现出色 发育和生殖生物学，以及一个明显的竞技场，这将为人类提供明显的机会 增长和提高竞争力是转化研究。在过去的三年里，IBR-COBRE 追求的主要战略目标是通过与以下机构合作， 妇产科与妇女健康系（Department of Obstetrics，Gynecology & Women's Health）Ob/Gyn）。六处Ob/Gyn是一个 医学院最成功的临床部门，最近已经积累了超过800万美元 为它的学术发展提供捐赠。IBR与Ob/Gyn的合作伙伴关系由 任命IBR-COBRE PI为该部研究司司长。妇产科11月， 2014.他管理着200万美元的夏尔马捐赠基金，该基金被指定用于该部门的研究。还 部妇产科最近聘请了一位医生兼科学家Men-Jean Lee博士，他是妇产科主任。 母胎医学。Lee博士在IBR的主要设施中获得了实验室空间，促进了合作 IBR和Ob/Gyn之间的关系。IBR的另外两名成员，M博士。沃德和加米尔是兼职教师 在部门。妇产科一个二期COBRE项目是一项临床研究，与部门合作。Ob/GYN 研究肥胖母亲所生儿童癌症增加的机制。这种合作关系已经 导致R 01检查患病胎盘的表观遗传变化。因此，IBR制定了一项 与最接近其研究重点的临床部门建立了强大而成功的伙伴关系。同相 中心将充分利用与教育部的合作关系。Ob/Gyn开发和实施灵活的翻译 研究试点项目计划，旨在开发转化研究项目，目标是 发展中心的新分支机构，扩大其竞争力。该计划将是灵活的，有两种类型 奖项，转化研究试点项目，需要IBR和Ob/Gyn教师之间的合作， 以及帮助研究人员弥补资金缺口的过渡基金。这些项目旨在开发 转化研究项目，引导成熟的研究人员通过资金失误，并提供一个灵活的， 和功能机制，以帮助已经在IBR竞争力的教师。