STRUCTURE OF E COLI RECEPTOR KINASES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 E.大肠杆菌组氨酸激酶受体（HKR）是位于细胞膜上的蛋白质，其作用是感受环境刺激。为了将信号传递到细胞并触发对刺激的反应，它们与其细胞内伴侣蛋白（称为反应调节剂（RR））一起工作。HKR和RR形成所谓的双组分系统（TCS），其是原核生物中的主要信号转导机制，也存在于真菌和植物中。大多数HKR具有两个跨膜结构域、周质传感器结构域和负责将信号转导至RR的大的胞质结构域。在E. coli中，但不知道全长蛋白的结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. E. coli histidine kinase receptors (HKR) are proteins located in the cell membrane and their role is to sense environmental stimuli. In order to transmit the signal to the cell and trigger a response to the stimulus they work together with their intracellular partner proteins, known as response regulators (RR). HKRs and RRs form the so-called Two Component Systems (TCS), which are the predominant signal transduction mechanisms in prokaryotic organisms, also present in fungi and plants. Most HKRs have two transmembrane domains ,a periplasmic sensor domain, and a large cytoplasmic domain which is responsible for the transduction of the signal to the RR. There are 23 identified HKRs in E. coli but a structure of no full length protein is known.