CS DOMAIN OF THE ESSENTIAL H/ACA RNP ASSEMBLY PROTEIN SHQ1

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 H/ACA核糖核蛋白颗粒是核糖体RNA和端粒酶RNA加工和代谢所必需的。Shq 1 p是真核生物H/ACA snoRNP合成和组装的重要因子。Shq 1 p被假定参与早期的生物合成步骤的H/ACA snoRNP复合物，和Shq 1 p耗尽导致特定的H/ACA snoRNA水平的降低和核糖体RNA加工的缺陷。Shq 1 p包含两个预测的结构域：一个N-末端CS（以含CHORD蛋白和SGT 1命名）或HSP 20样结构域，和一个称为Shq 1结构域的高度序列同源性的C-末端区域

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. H/ACA ribonucleoprotein particles are essential for ribosomal RNA and telomerase RNA processing and metabolism. Shq1p has been identified as an essential eukaryotic H/ACA snoRNP biogenesis and assembly factor. Shq1p is postulated to be involved in the early biogenesis steps of H/ACA snoRNP complexes, and Shq1p depletion leads to a specific decrease in H/ACA snoRNA levels and to defects in ribosomal RNA processing. Shq1p contains two predicted domains: an N-terminal CS (named after CHORD-containing proteins and SGT1) or HSP20-like domain, and a Cterminal region of high sequence homology called the Shq1 domain