CS DOMAIN OF THE ESSENTIAL H/ACA RNP ASSEMBLY PROTEIN SHQ1

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 H/ACA核糖核蛋白颗粒是核糖体RNA和端粒酶RNA处理和代谢所必需的。Shq1p是一个重要的真核生物H/ACA snoRNP的生物发生和组装因子。Shq1p被认为参与了H/ACA snoRNP复合体的早期生物发生步骤，Shq1p的缺失导致H/ACA snoRNA水平的特异性下降和核糖体RNA加工的缺陷。Shq1p包含两个预测结构域：N-末端CS(以含弦蛋白和SGT1命名)或类似HSP20的结构域，以及序列同源性较高的CT端区域，称为Shq1结构域

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. H/ACA ribonucleoprotein particles are essential for ribosomal RNA and telomerase RNA processing and metabolism. Shq1p has been identified as an essential eukaryotic H/ACA snoRNP biogenesis and assembly factor. Shq1p is postulated to be involved in the early biogenesis steps of H/ACA snoRNP complexes, and Shq1p depletion leads to a specific decrease in H/ACA snoRNA levels and to defects in ribosomal RNA processing. Shq1p contains two predicted domains: an N-terminal CS (named after CHORD-containing proteins and SGT1) or HSP20-like domain, and a Cterminal region of high sequence homology called the Shq1 domain