E COLI CLASS IA RIBONUCLEOTIDE REDUCTASE (RNR) HOLOCOMPLEX
E COLI CLASS IA RIBONUCLEOTIDE REDUCTASE (RNR) HOLOCOMPLEX
批准号:
8169292
负责人:
CATHERINE L DRENNAN
金额:
$0.41万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-04-01 至 2011-03-31
关键词:
Active SitesAddressBiochemicalCatalysisCellsComplexComputer Retrieval of Information on Scientific Projects DatabaseDeoxyribonucleotidesEnzymesEscherichia coliFundingGrantInstitutionLifeMethodsProteinsReactionResearchResearch PersonnelResourcesRibonucleotide ReductaseSourceStructureUnited States National Institutes of Health
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
核苷酸还原酶是细胞中脱氧核苷酸的唯一来源,因此对所有活细胞都是至关重要的。虽然存在多种类型的RNR,但人们对大肠杆菌I类酶已有广泛的研究。该反应需要两种蛋白质,活性部位含有?和自由基产生蛋白?该蛋白质为催化所需的活性部位提供了自由基。虽然这两个亚基的结构是已知的,但络合物中没有可用的结构,齐聚状态也不是很清楚。我们正试图获得一种复合体的结构,以开始解决迄今为止使用的生化和生物物理方法尚未解决的一些问题。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Ribonucleotide reductases are the sole source of deoxyribonucleotides in the cell and are thus vital for all living cells. While there are multiple classes of RNR's the E. coli class I enzyme has been extensively studied. The reaction requires two proteins, the active site containing ¿ and the radical generating protein ¿. The ¿ protein provides a radical to the active site of ¿, required for catalysis. While structures of the two subunits are known, there is no available structure of ¿ and ¿ in complex and the oligomerization state is not well known. We are attempting to obtain a structure of ¿ and ¿ in complex to begin to address some of the issues unresolved by biochemical and biophysical methods used so far.
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Metalloenzyme structure, function and assembly
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批准号:10621553
-
项目类别:
-
资助金额:$41.03万
-
财政年份:2018
-
负责人:CATHERINE L DRENNAN
-
依托单位:
Metalloenzyme structure, function and assembly
-
批准号:10413652
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项目类别:
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资助金额:$5.55万
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财政年份:2018
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负责人:CATHERINE L DRENNAN
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依托单位:
Metalloenzyme structure, function and assembly
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批准号:9906257
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项目类别:
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资助金额:$30.42万
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财政年份:2018
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负责人:CATHERINE L DRENNAN
-
依托单位:
Metalloenzyme structure, function and assembly
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批准号:10386844
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项目类别:
-
资助金额:$30.42万
-
财政年份:2018
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负责人:CATHERINE L DRENNAN
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依托单位:
SOLUTION SAXS STUDIES OF SUBUNIT INTERACTIONS IN RIBONUCLEOTIDE REDUCTASE
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批准号:8363533
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项目类别:
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资助金额:$2.28万
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财政年份:2011
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负责人:CATHERINE L DRENNAN
-
依托单位:
STRUCTURAL INSIGHT INTO A STAC-LIKE ACTIVE SITE USING A REBC MUTANT
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批准号:8169294
-
项目类别:
-
资助金额:$0.41万
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财政年份:2010
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负责人:CATHERINE L DRENNAN
-
依托单位:
PROTEIN ENGINEERING OF BIRA FOR PROTEIN TAGGING
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批准号:8169295
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项目类别:
-
资助金额:$0.41万
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财政年份:2010
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负责人:CATHERINE L DRENNAN
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依托单位:
COMPLEX OF CORRINOID IRON-SULFUR PROTEIN AND ITS METHYLTRANSFERASE
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批准号:8169291
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项目类别:
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资助金额:$0.41万
-
财政年份:2010
-
负责人:CATHERINE L DRENNAN
-
依托单位:
NON-HEME IRON HALOGENASES IN NON-RIBOSOMAL PEPTIDE SYNTHESIS (NRPS) PATHWAYS
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批准号:8169293
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项目类别:
-
资助金额:$0.41万
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财政年份:2010
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负责人:CATHERINE L DRENNAN
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依托单位:
HYDROXYPROPYLPHOSPHONIC ACID EPOXIDASE (HPPE) BOUND WITH SUBSTRATE ANALOGS
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批准号:8169296
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项目类别:
-
资助金额:$0.41万
-
财政年份:2010
-
负责人:CATHERINE L DRENNAN
-
依托单位:
TERTIARY AND QUATERNARY STRUCTURE CHARACTERIZATION OF METALLOENZYMES IN SOLUTION
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批准号:8171518
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项目类别:
-
资助金额:$1.43万
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财政年份:2010
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负责人:CATHERINE L DRENNAN
-
依托单位:
HIGH PRESSURE COOLING OF E COLI CLASS IA RIBONUCLEOTIDE REDUCTASE COMPLEX
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批准号:8171517
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项目类别:
-
资助金额:$1.43万
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财政年份:2010
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负责人:CATHERINE L DRENNAN
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依托单位:
CRYSTALLOGRAPHIC STUDIES OF NATURAL PRODUCT BIOSYNTHESIS
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批准号:7955170
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项目类别:
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资助金额:$1.07万
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财政年份:2009
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负责人:CATHERINE L DRENNAN
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依托单位:
REGULATION OF TRACE METAL UPTAKE IN BACTERIA
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批准号:7955088
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项目类别:
-
资助金额:$1.07万
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财政年份:2009
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负责人:CATHERINE L DRENNAN
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依托单位:
2009 Vitamin B12 and Corphins Gordon Conference
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批准号:7743612
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项目类别:
-
资助金额:$1.5万
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财政年份:2009
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负责人:CATHERINE L DRENNAN
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依托单位:
METALLOENZYMES AND MEDICINE
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批准号:7721208
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项目类别:
-
资助金额:$0.01万
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财政年份:2008
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负责人:CATHERINE L DRENNAN
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依托单位:
LYSINE 5-6-AMINOMUTASE
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批准号:7182927
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项目类别:
-
资助金额:$0.82万
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财政年份:2005
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负责人:CATHERINE L DRENNAN
-
依托单位:
METALLOENZYMES AND MEDICINE
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批准号:7369499
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项目类别:
-
资助金额:$0.01万
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财政年份:2005
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负责人:CATHERINE L DRENNAN
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依托单位:
CRYSTALS NICKEL-RESPONSIVE TRANSCRIPTION FACTOR NIKR
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批准号:6972721
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项目类别:
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资助金额:$7.49万
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财政年份:2004
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负责人:CATHERINE L DRENNAN
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依托单位:
Complex Metallocluster Structure and Assembly
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批准号:8286294
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项目类别:
-
资助金额:$26.65万
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财政年份:2004
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负责人:CATHERINE L DRENNAN
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依托单位:
海外基金