BONE GRAFT SUBSTITUTE FOR INTER-BODY SPINAL FUSION

体间脊柱融合的骨移植替代品

• 批准号: 8172711
• 负责人: KAREN S RICE
• 金额: $ 9.06万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172711
• 关键词: Autologous; Bone Transplantation; Clinical; Computer Retrieval of Information on Scientific Projects Database; Funding; Gold; Grant; Healed; Hip Fractures; Implant; Institution; Laceration; Low Back Pain; Operative Surgical Procedures; Pain; Papio; Patients; Pelvis; Process; Research; Research Personnel; Resources; Societies; Source; Spinal Fusion; Testing; United States National Institutes of Health; Vertebral column; bone; healing; relating to nervous system; research study; vertebra body

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Spine ailments are amongst the most common and costly illnesses of today's societies. In the US alone, 30 billion dollars are spent annually for the surgical treatment of low back pain. About 400,000 such surgeries are performed every year. The gold standard, in 2008, still is to perform a spine fusion, using spongy bone of the patient's own pelvis (so called autologous iliac crest bone graft). To obtain the latter is often associated with prolonged pain (up to 30% of the patients), but also more serious complications such as vessel lacerations, neural damage, pelvic or hip fracture, etc. To use an artificial material that is forming a bone fusion just as bone does, would avoid taking bone from the pelvis. A new artificial material shall be tested in a baboon experiment for its clinical suitability. During a six month survival period the implant spacer is expected to bony integrate and thus form a stable bridge between the two adjacent vertebral bodies (this process is called a spine fusion). The artificial material is tested for achieving at least equal or possibly even better healing results compared to natural bone.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 脊柱疾病是当今社会最常见和最昂贵的疾病之一。仅在美国，每年就有300亿美元用于手术治疗腰痛。每年约有40万例此类手术。2008年的黄金标准仍然是使用患者自身骨盆的松质骨（所谓的自体髂嵴骨移植）进行脊柱融合。为了获得后者往往与长期疼痛（高达30%的患者），但也更严重的并发症，如血管撕裂，神经损伤，骨盆或髋部骨折等，使用人工材料，形成骨融合就像骨一样，将避免从骨盆取骨。应在狒狒实验中测试新的人工材料的临床适用性。 在6个月的生存期内，预计植入物融合器会骨整合，从而在两个相邻椎体之间形成稳定的桥（该过程称为脊柱融合）。测试人造材料以实现与天然骨相比至少相等或甚至可能更好的愈合结果。