DIET AND GENOTYPE IN PRIMATE ATHEROSCLEROSIS: VETERINARY SERVICES

灵长类动脉粥样硬化的饮食和基因型：兽医服务

• 批准号: 8357665
• 负责人: KAREN S RICE
• 金额: $ 35.77万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357665
• 关键词: Adipose tissue; Animal Technicians; Animals; Atherosclerosis; Biopsy; Birth Records; Blood; Breeding; Caring; Cholesterol; Collection; Databases; Diet; Dietary Fats; Funding; Genotype; Grant; Healthcare; Maintenance; Monitor; Muscle; National Center for Research Resources; Papio; Pregnancy; Primates; Principal Investigator; Procedures; Records; Research; Research Infrastructure; Resources; Services; Source; United States National Institutes of Health; Veterinarians; animal colony; base; cost; feeding; femoral artery; liver biopsy; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is Core C of the Program Project "Diet and Genotype in Primate Atherosclerosis". Core Unit C is responsible for maintaining the pedigreed baboon colony, managing the breeding groups, and conducting the experimental procedures using baboons. Colony maintenance includes daily care, i.e., feeding assigned diets, cleaning cages, observing animals for signs of illness, treating sick animals, and maintaining animal database records. Breeding colony management includes maintaining sire-dam assignments, monitoring dams for pregnancies, recording births in the animal database, and culling unproductive animals from the colony. Experimental procedures include administration of the high cholesterol, high fat dietary challenge, blood collections, femoral artery biopsies, liver biopsies, muscle biopsies, and adipose tissue biopsies. Animal caretakers are responsible for animal maintenance on a daily basis. Veterinarians or veterinary technicians provide health care, prepare experimental diet, and are responsible for experimental procedures.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这是“灵长类动脉粥样硬化的饮食和基因型”项目的核心C。 核心单位C负责维护纯种狒狒群体，管理繁殖组，并使用狒狒进行实验程序。菌落维护包括日常护理，即，喂食指定的饲料、清洁笼舍、观察动物的疾病体征、治疗患病动物以及维护动物数据库记录。繁殖群体管理包括维持母畜分配、监测母畜妊娠、在动物数据库中记录出生情况以及从殖民地剔除无生产力的动物。实验程序包括施用高胆固醇、高脂肪饮食挑战、血液收集、股动脉活检、肝活检、肌肉活检和脂肪组织活检。动物管理员负责动物的日常维护。兽医或兽医技术人员提供医疗保健，准备实验饮食，并负责实验程序。