IMMUNOGENICITY OF PROCESSED EQUINE XENOGRAFT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究将评估处理马肌腱和软骨栓（一块附着软骨的骨头）的不同方法，最终目标是将它们用于人体移植。组织的处理旨在减少可能导致人体排斥或反应的物质的量。将一小片经处理的肌腱或软骨栓植入狒狒背部的皮肤下，并放置30天。30天后，将取出植入物和一些周围组织，并由病理学家评价移植物接受/排斥。这些研究的结果将提供有关处理的有效性的有价值的信息，以使移植物可用于人类使用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate different methods of processing equine (horse) tendon and chondroplug (a piece of bone with cartilage attached) with the ultimate goal of using them for human transplantation. The processing of the tissue is designed to reduce the amount of substances that might cause rejection or reaction in a human. A small piece of treated tendon or chondroplug will be implanted under the skin on the back of the baboon and left for 30 days. After 30days, the implants, plus some surrounding tissue, will be removed and graft acceptance/rejection will be evaluated by a pathologist. The outcome of these studies will provide valuable information about the efficacy of processing to make the transplant acceptable for human use.