IMMUNOGENICITY OF PROCESSED EQUINE XENOGRAFT

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究将评估处理马肌腱和软骨栓（一块附有软骨的骨头）的不同方法，最终目标是将它们用于人体移植。组织的处理旨在减少可能引起人体排斥或反应的物质的量。一小块经过处理的肌腱或软骨塞将被植入狒狒背部的皮下，并保留 30 天。 30 天后，植入物以及一些周围组织将被移除，病理学家将评估移植物的接受/拒绝。这些研究的结果将提供有关加工效率的有价值的信息，以使移植物可供人类使用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate different methods of processing equine (horse) tendon and chondroplug (a piece of bone with cartilage attached) with the ultimate goal of using them for human transplantation. The processing of the tissue is designed to reduce the amount of substances that might cause rejection or reaction in a human. A small piece of treated tendon or chondroplug will be implanted under the skin on the back of the baboon and left for 30 days. After 30days, the implants, plus some surrounding tissue, will be removed and graft acceptance/rejection will be evaluated by a pathologist. The outcome of these studies will provide valuable information about the efficacy of processing to make the transplant acceptable for human use.