IMMUNOGENICITY OF PROCESSED EQUINE XENOGRAFT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将评估处理马(马)腱和软骨塞(一块附着软骨的骨头)的不同方法，最终目标是将它们用于人类移植。对组织的处理旨在减少可能导致人体排斥或反应的物质的数量。一小块经过处理的肌腱或软骨塞将被植入狒狒背部的皮肤下，放置30天。30天后，植入物以及周围的一些组织将被移除，移植接受/排斥将由病理学家进行评估。这些研究的结果将提供有关使移植供人类使用的处理效果的有价值的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate different methods of processing equine (horse) tendon and chondroplug (a piece of bone with cartilage attached) with the ultimate goal of using them for human transplantation. The processing of the tissue is designed to reduce the amount of substances that might cause rejection or reaction in a human. A small piece of treated tendon or chondroplug will be implanted under the skin on the back of the baboon and left for 30 days. After 30days, the implants, plus some surrounding tissue, will be removed and graft acceptance/rejection will be evaluated by a pathologist. The outcome of these studies will provide valuable information about the efficacy of processing to make the transplant acceptable for human use.