ROLE OF THE BRAINSTEM IN VOLUNTARY GAZE SHIFTS

脑干在自愿目光转移中的作用

• 批准号: 8172731
• 负责人: ALBERT Frederick FUCHS
• 金额: $ 15.51万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172731
• 关键词: Action Potentials; Behavior; Brain Stem; Cerebellum; Computer Retrieval of Information on Scientific Projects Database; Eye; Eye Movements; Funding; Grant; Head; Head Movements; Institution; Neurons; Pattern; Production; Research; Research Personnel; Resources; Rest; Role; Saccades; Semicircular canal structure; Signal Transduction; Source; Time; United States National Institutes of Health; gaze; interest

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, we have been studying the role of the brain stem and cerebellum in the production of head-unrestrained gaze shifts from one object of interest to another. Such gaze shifts are composed of an eye saccade and a head movement. There are 3 studies within this project. First, we have finished analyzing the behavior of brain stem neurons that discharge a burst of action potentials with normal head unrestrained gaze shifts. The duration and number of spikes in the burst are best correlated with the eye movement component of the gaze shift. Second, because the eye component and overall gaze shift are tightly correlated in normal gaze shifts, we dissociated them by plugging the semicircular canals, which deliver a signal related to head movement to the brain stem. Under these conditions, the eye saccade always ends before the gaze lands and the head carries the eye the rest of the way. In this situation, the burst is unambiguously related to the eye saccade. Finally, we recorded from the part of the cerebellum whose neurons project to the burst generator. Neurons there have discharge patterns that help accelerate gaze shifts in one horizontal direction and decelerate them in the other. Moreover, the bursts of those neurons are tightly timed with the end of the gaze shift and probably are instrumental in insuring that the gaze stops at the appropriate time to land on target.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这项研究中，我们一直在研究脑干和小脑在头部自由凝视从一个感兴趣的物体转移到另一个感兴趣的物体的过程中所起的作用。这种凝视转移由眼跳和头部运动组成。在这个项目中有3项研究。首先，我们已经完成了对脑干神经元行为的分析，这些神经元在正常头部自由凝视转移的情况下释放出一连串的动作电位。突发波的持续时间和数量与凝视转移的眼动成分有很好的相关性。其次，因为在正常的凝视转移中，眼睛成分和整体凝视转移是紧密相关的，我们通过堵塞半规管来分离它们，半规管向脑干传递与头部运动相关的信号。在这种情况下，眼跳总是在凝视落地之前结束，头部在剩下的过程中携带着眼睛。在这种情况下，脉冲波毫无疑问与眼跳有关。最后，我们记录了小脑中神经元投射到脉冲发生器的那部分。那里的神经元有放电模式，有助于加速一个水平方向的凝视转移，并减缓另一个方向的凝视转移。此外，这些神经元的爆发与凝视转移的结束密切相关，可能有助于确保凝视在适当的时间停下来，落在目标上。