BRAIN MECHANISMS MEDIATING GENETIC RISK FACTORS FOR ANXIETY AND DEPRESSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：探讨脑发育的遗传学基础和焦虑、抑郁的发病机制。 为了了解情绪神经回路的遗传性，可能会影响大脑对行为挑战的反应的候选基因正在被定义。这些研究将进一步加深我们对易患焦虑和抑郁的遗传基础的理解。 这项工作使用了WNPRC动物服务、运营服务和图书馆和信息服务。 出版物： 克里斯蒂安BT，福克斯AS，奥勒JA，范德希NT，穆拉利D，罗杰斯J，奥克斯tr，谢尔顿SE，戴维森RJ，卡林NH。(2009)使用[C-11]DASB PET在非人灵长类动物脑中的5-羟色胺转运体结合和基因分型。NeuroImage，Epub领先于印刷品。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate the genetic basis of brain development and mechanisms underlying anxiety and depression. Candidate genes that are likely to influence the brain's response to a behavioral challenge in order to understand the heritability of the neurocircuitry of emotion are being defined. These studies will further our understanding of the genetic bases of vulnerability to anxiety and depression. This work used WNPRC Animal Services, Operational Services, and Library and Information Services. PUBLICATION: Christian BT, Fox AS, Oler JA, Vandehey NT, Murali D, Rogers J, Oakes TR, Shelton SE, Davidson RJ, Kalin NH. (2009) Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. Neuroimage, Epub ahead of print.