BRAIN MECHANISMS MEDIATING GENETIC RISK FACTORS FOR ANXIETY AND DEPRESSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：探讨脑发育的遗传基础及焦虑、抑郁的发病机制。 为了理解情绪神经回路的遗传性，可能影响大脑对行为挑战的反应的候选基因正在被定义。 这些研究将进一步加深我们对易患焦虑和抑郁症的遗传基础的理解。 这项工作使用WNPRC动物服务，运营服务，图书馆和信息服务。 出版物： Christian BT，Fox AS，Oler JA，Vandehey NT，Murali D，Rogers J，奥克斯TR，谢尔顿SE，戴维森RJ，Kalin NH.（2009）使用[C-11]DASB PET的非人灵长类动物大脑中的血清素转运蛋白结合和基因型。神经影像，印刷前的电子版。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate the genetic basis of brain development and mechanisms underlying anxiety and depression. Candidate genes that are likely to influence the brain's response to a behavioral challenge in order to understand the heritability of the neurocircuitry of emotion are being defined. These studies will further our understanding of the genetic bases of vulnerability to anxiety and depression. This work used WNPRC Animal Services, Operational Services, and Library and Information Services. PUBLICATION: Christian BT, Fox AS, Oler JA, Vandehey NT, Murali D, Rogers J, Oakes TR, Shelton SE, Davidson RJ, Kalin NH. (2009) Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. Neuroimage, Epub ahead of print.