EMOTIONAL PROCESSING

情绪处理

• 批准号: 8358191
• 负责人: Ned H Kalin
• 金额: $ 15.64万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358191
• 关键词: Accounting; Address; Adrenal Glands; Amygdaloid structure; Animals; Anxiety; Biological Psychiatry; Brain; Cognitive; Emotional; Emotions; Foxes; Funding; Grant; Human; Hypothalamic structure; Individual Differences; Information Services; Journals; Lesion; Library Services; Maps; Medial; Mediating; National Center for Research Resources; Neurosciences; Pathology; Physiologic pulse; Physiological; Pituitary Gland; Prefrontal Cortex; Primates; Principal Investigator; Process; Psychopathology; Research; Research Infrastructure; Resources; Role; Services; Source; Structure of terminal stria nuclei of preoptic region; System; United States National Institutes of Health; Wisconsin; Work; cost; relating to nervous system; showing emotion

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To understand the neural system underlying the expression of emotion in primates. Using EPI pulse sequence mapping of functional brain connectivity and accounting for physiological fluctuations, we have found a significant connectivity between the mid- posterior cingulated region and the medial PFC. In addition, we have found indications of connectivity in the "default network," thought to be associated with integrating cognitive and emotional processes, that included regions of the medial PFC and the insular. The findings from these studies will be highly relevant to humans, addressing the role of amygdala-orbitofrontal interactions in mediating normal emotion and psychopathology. This work used WNPRC Animal Services, Pathology, Operational Services, and Library & Information Services. PUBLICATIONS: Jahn AL, Fox AS, Abercrombie HC, Shelton SE, Oakes TR, Davidson RJ, Kalin NH. (2010) Subgenual prefrontal cortex activity predicts individual differences in hypothalamic-pituitary-adrenal activity across different contexts. Biological Psychiatry 67(2), 175-81. PMID: 19846063, PMCID: PMC2804442. Fox AS, Shelton SE, Oakes TR, Converse AK, Davidson RJ, Kalin NH. (2010) Orbitofrontal Cortex Lesions Alter Anxiety-Related Activity in the Primate Bed Nucleus of Stria Terminalis. Journal of Neuroscience, 30 (20), 7023-7027. PMID: 20484644, PMCID: PMC2915894.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 目的：了解情感表达的神经系统 灵长类动物。 使用功能性大脑连接性的EPI脉冲序列映射和考虑 生理波动，我们发现了中部之间有显着的连通性 后扣带区域和内侧PFC。此外，我们发现了 “默认网络”中连接性的指示，被认为与 整合认知和情感过程，包括内侧区域 PFC和岛屿。这些研究的发现将与 人类，解决杏仁核 - 轨道额相互作用在中介中的作用 正常的情绪和心理病理学。 这项工作使用了WNPRC动物服务，病理学，操作服务和图书馆 ＆信息服务。 出版物： Jahn AL，Fox AS，Abercrombie HC，Shelton SE，Oakes TR，Davidson RJ，Kalin NH。 （2010）亚属前额叶皮层活性预测了个体差异 下丘脑 - 垂体 - 肾上腺活性在不同情况下。 生物精神病学 67（2），175-81。 PMID：19846063，PMCID：PMC2804442。 Fox AS，Shelton SE，Oakes TR，Converse AK，Davidson RJ，Kalin NH。 （2010） 眶额皮层病变改变了灵长类床核中与焦虑相关的活性 Stria末端。神经科学杂志，30（20），7023-7027。 PMID：20484644， PMCID：PMC2915894。