EMOTIONAL PROCESSING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：了解老年人情绪表达的神经系统。 灵长类动物。 使用EPI脉冲序列图进行脑功能连接并解释 生理波动，我们发现了一个显著的连接在中期 后扣带区和PFC内侧。此外，我们还发现， “默认网络”中的连通性指示，被认为与 整合认知和情绪过程，包括内侧脑区 一等兵和岛国。这些研究的结果将与以下方面高度相关 人类，解决杏仁核-眼眶额叶相互作用在调节 正常的情绪和精神病态。 这项工作使用了WNPRC动物服务、病理学、运营服务和图书馆 &信息服务。 出版物： Jahn AL，Fox AS，Abercrombie HC，Shelton SE，Okers tr，Davidson RJ，Kalin NH。 (2010)亚膝前额叶皮质活动预测个体差异 不同背景下的下丘脑-垂体-肾上腺活动。生物精神病学 67(2)，175-81。PMID：19846063，PMC2804442。 福克斯AS，谢尔顿SE，奥克斯tr，匡威AK，戴维森RJ，卡林NH。(2010年) 损毁眶前皮质改变灵长类动物床核的焦虑相关活动 终纹。神经科学杂志，30(20)，7023-7027。PMID：20484644， PMCID：PMC2915894。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To understand the neural system underlying the expression of emotion in primates. Using EPI pulse sequence mapping of functional brain connectivity and accounting for physiological fluctuations, we have found a significant connectivity between the mid- posterior cingulated region and the medial PFC. In addition, we have found indications of connectivity in the "default network," thought to be associated with integrating cognitive and emotional processes, that included regions of the medial PFC and the insular. The findings from these studies will be highly relevant to humans, addressing the role of amygdala-orbitofrontal interactions in mediating normal emotion and psychopathology. This work used WNPRC Animal Services, Pathology, Operational Services, and Library & Information Services. PUBLICATIONS: Jahn AL, Fox AS, Abercrombie HC, Shelton SE, Oakes TR, Davidson RJ, Kalin NH. (2010) Subgenual prefrontal cortex activity predicts individual differences in hypothalamic-pituitary-adrenal activity across different contexts. Biological Psychiatry 67(2), 175-81. PMID: 19846063, PMCID: PMC2804442. Fox AS, Shelton SE, Oakes TR, Converse AK, Davidson RJ, Kalin NH. (2010) Orbitofrontal Cortex Lesions Alter Anxiety-Related Activity in the Primate Bed Nucleus of Stria Terminalis. Journal of Neuroscience, 30 (20), 7023-7027. PMID: 20484644, PMCID: PMC2915894.