BRAIN MECHANISMS MEDIATING GENETIC RISK FACTORS FOR ANXIETY AND DEPRESSION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：探讨脑发育的遗传学基础及其机制。 焦虑和抑郁。 我们正在定义可能影响大脑对行为挑战反应的候选基因，以了解情绪神经回路的遗传性。这些研究将进一步加深我们对易患焦虑和抑郁的遗传基础的理解。 这项工作使用了WNPRC动物服务、运营服务和图书信息服务。 出版物： 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容 布兰杰罗·J·卡林NH。(2010)焦虑的杏仁核和海马区底物 气质的遗传性不同。自然466(7308)：864-8PMID为20703306。PMCID PMC2998538。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To investigate the genetic basis of brain development and mechanisms underlying anxiety and depression. We are defining candidate genes that are likely to influence the brain's response to a behavioral challenge in order to understand the heritability of the neurocircuitry of emotion. These studies will further our understanding of the genetic bases of vulnerability to anxiety and depression. This work used WNPRC Animal Services, Operational Services, and Library & Information Services. PUBLICATION: Oler JA, Fox AS, Shelton SE, Rogers J, Dyer TD, Davidson RJ, Shelledy W, Oakes TR, Blangero J Kalin NH. (2010) Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. Nature 466(7308):864-8. PMID 20703306. PMCID PMC2998538.