BRAIN MECHANISMS MEDIATING GENETIC RISK FACTORS FOR ANXIETY AND DEPRESSION

调节焦虑和抑郁遗传风险因素的大脑机制

• 批准号: 8358229
• 负责人: Ned H Kalin
• 金额: $ 33.39万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358229
• 关键词: Animals; Anxiety; Base of the Brain; Behavioral; Brain; Candidate Disease Gene; Development; Emotions; Foxes; Funding; Genetic; Grant; Heritability; Hippocampus (Brain); Information Services; Library Services; Mediating; Mental Depression; National Center for Research Resources; Nature; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Services; Source; Temperament; United States National Institutes of Health; Wisconsin; Work; base; cost; genetic risk factor; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To investigate the genetic basis of brain development and mechanisms underlying anxiety and depression. We are defining candidate genes that are likely to influence the brain's response to a behavioral challenge in order to understand the heritability of the neurocircuitry of emotion. These studies will further our understanding of the genetic bases of vulnerability to anxiety and depression. This work used WNPRC Animal Services, Operational Services, and Library & Information Services. PUBLICATION: Oler JA, Fox AS, Shelton SE, Rogers J, Dyer TD, Davidson RJ, Shelledy W, Oakes TR, Blangero J Kalin NH. (2010) Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. Nature 466(7308):864-8. PMID 20703306. PMCID PMC2998538.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 目的：探讨脑发育的遗传基础及其机制 焦虑和抑郁。 我们正在定义可能影响大脑对行为挑战的反应的候选基因，以了解情绪神经回路的遗传性。这些研究将进一步加深我们对易患焦虑和抑郁症的遗传基础的理解。 这项工作使用WNPRC动物服务，运营服务，图书馆和信息服务。 出版物： Oler JA，Fox AS，谢尔顿SE，罗杰斯J，戴尔TD，戴维森RJ，Shelledy W，奥克斯TR， Blangero J Kalin NH. 03 The Dog（2010） 气质的遗传性不同。Nature 466（7308）：864-8. PMID 20703306。PMCID PMC2998538。