EFFECTS OF BRAIN GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)

脑葡萄糖依赖性促胰岛素多肽 (GIP) 的作用

• 批准号: 8172692
• 负责人: ROBERT E SHADE
• 金额: $ 2.03万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172692
• 关键词: Brain; Computer Retrieval of Information on Scientific Projects Database; Funding; GNAI2 gene; Glucose; Grant; Hormones; Institution; Oral; Papio; Research; Research Personnel; Resources; Role; Signal Transduction; Small Intestines; Source; Testing; United States National Institutes of Health; body sense; gastric inhibitory polypeptide receptor; insulin sensitivity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that a recently discovered hormone synthesized by the small intestine, glucose-dependent insulinotropic polypeptide(GIP), has a role in brain signaling related to sensing body glucose availability. This will be done by estimating insulin sensitivity to an oral glucose challenge in baboons before and after chronically increasing brain GIP levels.

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