OF LOWER BODY NEGATIVE PRESSURE AS A HYPOVOLEMIA MODEL IN BABOONS

下半身负压作为狒狒低血容量模型的研究

• 批准号: 8357708
• 负责人: ROBERT E SHADE
• 金额: $ 3.98万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357708
• 关键词: Abdomen; Blood; Blood Volume; Cardiovascular system; Conscious; Funding; Grant; Head; Heart; Hemorrhage; Hormonal; Human; Hypovolemia; Lower Body Negative Pressure; Lower Extremity; Modeling; National Center for Research Resources; Papio; Physiological; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Simulate; Source; Staging; Testing; United States National Institutes of Health; cost; pressure; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Lower body negative pressure (LBNP) has been used to simulate loss of central blood volume (e.g., hemorrhage) in conscious, healthy humans. The application of negative pressure to the lower body results in a redistribution of blood away from the upper body (head and heart) to the lower extremities and abdomen, stimulating the same physiological responses as during the initial stages of actual hemorrhage. While LBNP has been used as a model of hemorrhage, the exact equivalence between levels of LBNP and actual blood loss has not been determined. Thus, the purpose of the proposed study is to correlate the physiological responses to LBNP with responses to actual hemorrhage in baboons. The aims of this study are to test the feasibility of using LBNP as a model of hypovolemia in baboons, and to compare cardiovascular and hormonal responses during LBNP and actual hemorrhage.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 下半身负压 (LBNP) 已被用来模拟意识清醒的健康人的中心血容量损失（例如出血）。 对下半身施加负压会导致血液从上半身（头部和心脏）重新分配到下肢和腹部，从而刺激与实际出血初始阶段相同的生理反应。 虽然 LBNP 已被用作出血模型，但 LBNP 水平与实际失血量之间的确切等价性尚未确定。 因此，本研究的目的是将狒狒对 LBNP 的生理反应与对实际出血的反应联系起来。 本研究的目的是测试使用 LBNP 作为狒狒低血容量模型的可行性，并比较 LBNP 和实际出血期间的心血管和激素反应。