OF LOWER BODY NEGATIVE PRESSURE AS A HYPOVOLEMIA MODEL IN BABOONS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 下体负压(LBNP)已经被用来模拟清醒的健康人的中心血容量的丧失(例如出血)。对下半身施加负压会导致血液从上半身(头部和心脏)重新分配到下肢和腹部，刺激与实际出血初期相同的生理反应。虽然下体负压已被用作出血模型，但下体负压水平与实际失血量之间的确切等价性尚未确定。因此，拟议的研究目的是将对下体负压的生理反应与对实际出血的反应联系起来。本研究的目的是测试下体负压作为狒狒低血容量模型的可行性，并比较下体负压和实际出血时的心血管和激素反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Lower body negative pressure (LBNP) has been used to simulate loss of central blood volume (e.g., hemorrhage) in conscious, healthy humans. The application of negative pressure to the lower body results in a redistribution of blood away from the upper body (head and heart) to the lower extremities and abdomen, stimulating the same physiological responses as during the initial stages of actual hemorrhage. While LBNP has been used as a model of hemorrhage, the exact equivalence between levels of LBNP and actual blood loss has not been determined. Thus, the purpose of the proposed study is to correlate the physiological responses to LBNP with responses to actual hemorrhage in baboons. The aims of this study are to test the feasibility of using LBNP as a model of hypovolemia in baboons, and to compare cardiovascular and hormonal responses during LBNP and actual hemorrhage.