EFFECTS OF BRAIN GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)

脑葡萄糖依赖性促胰岛素多肽 (GIP) 的作用

• 批准号: 8357673
• 负责人: ROBERT E SHADE
• 金额: $ 1.19万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357673
• 关键词: Brain; Funding; Glucose; Grant; Hormones; National Center for Research Resources; Oral; Papio; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Signal Transduction; Small Intestines; Source; Testing; United States National Institutes of Health; body sense; cost; gastric inhibitory polypeptide receptor; insulin sensitivity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This study will test the hypothesis that a recently discovered hormone synthesized by the small intestine, glucose-dependent insulinotropic polypeptide(GIP), has a role in brain signaling related to sensing body glucose availability. This will be done by estimating insulin sensitivity to an oral glucose challenge in baboons before and after chronically increasing brain GIP levels.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这项研究将测试一种最近发现的由小肠合成的激素的假设， 促胰岛素多肽（GIP）在与感知身体葡萄糖可用性相关的脑信号传导中起作用。会来做这项工作 评估狒狒在慢性增加脑GIP水平之前和之后对口服葡萄糖挑战的胰岛素敏感性。