MOSAIC VACCINE-ELICITED IMMUNE RESPONSES IN RHESUS MONKEYS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 成功的HIV疫苗的创建将需要开发一种免疫原，该免疫原将产生具有足够跨分支宽度的细胞免疫，以应对病毒的极端遗传多样性。最近有人提出，基于集中的HIV基因序列的疫苗可能会为流行的HIV病毒株的遗传异质性所带来的问题提供解决方案。 共有和多价嵌合免疫原都是基于集中的基因序列。本研究旨在探讨与共识免疫原相比，多价嵌合体疫苗接种产生的CD 4+和CD 8 + T淋巴细胞应答的广度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Creation of a successful HIV vaccine will require development of an immunogen that will generate cellular immunity with sufficient cross-clade breadth to deal with the extreme genetic diversity of the virus. Recently it has been suggested that vaccines based on centralized HIV gene sequences might provide a solution to the problem posed by the genetic heterogeneity of the circulating strains of HIV. Both consensus and polyvalent mosaic immunogens are based on centralized gene sequences. The present study was designed to explore the breadth of CD4+ and CD8+ T lymphocyte responses generated by vaccination with polyvalent mosaic as compared to vaccination with consensus immunogens.