RNA EXPRESSION PROFILES OF SIV-SPECIFIC CD8+ T CELLS

SIV 特异性 CD8 T 细胞的 RNA 表达谱

• 批准号: 8172906
• 负责人: NORMAN L LETVIN
• 金额: $ 6.58万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172906
• 关键词: CD8B1 gene; Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Genotype; Grant; Institution; Macaca mulatta; Mamu-A 02 antigen; Molecular Profiling; Monkeys; Plasma; Play; RNA; Research; Research Personnel; Resources; Role; Source; T-Lymphocyte; Testing; Transcript; United States National Institutes of Health; Viral Load result; Viremia; Virus

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is known that SIV-infected Mamu-A superscript 01+ rhesus macaques develop lower plasma viral loads than Mamu-A*01- monkeys. CD8+ T cells possibly play a role in the control of viremia. To test this hypothesis SIV-specific CD8+ T cells from Mamu-A*01+ (A*02-, B*17-,B*08-) monkeys and Mamu-A*02+ (A*01-, B*17-, B*08-) monkeys are being isolated. Virus-specific CD8+ T cells may be different in Mamu-A*01+ monkeys from those on Mamu-A*02+ monkeys. This difference may be reflected in the RNA transcripts that are present in the virus-specific CD8+ T cells from monkeys with different genotypes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 众所周知，SIV感染的Mamu-A上标01+猕猴比Mamu-A*01-猴子发出的血浆病毒载荷低。 CD8+ T细胞可能在控制病毒血症的控制中起作用。为了测试Mamu-A*01+（A*02-，B*17-，B*08-）Monkeys和Mamu-A*02+（A*01-，B*17-，B*08-）猴子的假设SIV特异性CD8+ T细胞。在Mamu-A*01+猴子中，病毒特异性CD8+ T细胞与Mamu-A*02+猴子的猴子可能有所不同。 这种差异可以反映在具有不同基因型的猴子的病毒特异性CD8+ T细胞中存在的RNA转录物中。