Sub-Voxel Tissue Characterization With In-Vivo MRI

使用体内 MRI 进行亚体素组织表征

• 批准号: 8333253
• 负责人: MARK D DOES
• 金额: $ 34.58万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8333253
• 关键词: Address; Anatomy; Autistic Disorder; Biological Markers; Caliber; Cerebrum; Characteristics; Chemicals; Clinical; Complex; Computer Simulation; Data; Development; Diagnostic; Diagnostic Imaging; Diffusion; Disease; Duchenne muscular dystrophy; Environment; Evaluation; Exhibits; Fibrosis; Foundations; Funding; Gold; Histology; Image; Imagery; Inflammation; Injury; Magnetic Resonance Imaging; Measures; Methods; Modeling; Muscle; Muscular Dystrophies; Myelin; Neuraxis; Nuclear Magnetic Resonance; Paper; Peripheral; Physiologic pulse; Preparation; Protocols documentation; Protons; Rattus; Relaxation; Reperfusion Injury; Research; Research Personnel; Schizophrenia; Signal Transduction; Skeletal Muscle; Slice; Specificity; Spinal; Testing; Thick; Tissue Model; Tissues; Translating; Variant; Water; Work; base; clinically relevant; computerized tools; imaging modality; in vivo; injured; method development; model development; mouse model; novel; prognostic; programs; relating to nervous system; research study; simulation; soft tissue; water diffusion; white matter

PROJECT SUMMARY Magnetic resonance imaging (MRI) is a uniquely informative soft tissue imaging modality with contrast that is sensitive to a myriad of physical, chemical, and functional characteristics of tissue but often lacks specificity. On the spatial scale relevant to water proton (1H) nuclear magnetic resonance (NMR), tissues are heterogeneous and, consequently, exhibit an NMR signal that is the complex summation of spatially varying characteristics. Most MRI protocols provide contrast between tissues that can be resolved spatially, but yield little or no quantitative information about the variation in NMR signal that exists on a smaller scale, that is, the sub-voxel scale. This quantitative sub-voxel information is alluring because it provides specificity to tissue micro-anatomy. Development of quantitative sub-voxel MRI tissue characterization requires coordinated advancement on two fronts: 1) quantitative models that relate relevant micro-anatomical characteristics to 1H NMR signal characteristics, and 2) practical and effective quantitative MRI methods that can translate these the use of sub-voxel tissue models to widespread utility for researchers and clinicians. The proposed studies address both modeling and method development with the aim to develop practical and quantitative imaging biomarkers for micro-anatomical characteristics of white matter and skeletal muscle, including 1) myelin volume fraction and myelin thickness in normal, developing, and abnormally developing white matter, and 2) myofiber volume fraction and size, in the presence of inflammation and fibrosis. Such biomarkers have the potential to impact research and clinical diagnostics by providing quantitative and specific measures to track changes in disorders associated with abnormal white matter development, such as Schizophrenia and Autism, as well muscle injuries and diseases such as Muscular Dystrophy.

项目概要 磁共振成像 (MRI) 是一种独特的信息丰富的软组织成像方式，其对比度 对组织的无数物理、化学和功能特征敏感，但往往缺乏特异性。 在与水质子 (1H) 核磁共振 (NMR) 相关的空间尺度上，组织是 异质性，因此表现出 NMR 信号，该信号是空间变化的复杂总和 特征。大多数 MRI 协议提供可以在空间上解析的组织之间的对比度，但会产生 关于小尺度 NMR 信号变化的定量信息很少或没有，即 亚体素尺度。这种定量的亚体素信息很有吸引力，因为它提供了组织的特异性 显微解剖学。定量亚体素 MRI 组织表征的发展需要协调 在两个方面取得进展：1）将相关微观解剖特征与1H联系起来的定量模型 NMR 信号特征，以及 2) 实用且有效的定量 MRI 方法，可以将这些方法转化为 亚体素组织模型的使用为研究人员和临床医生提供了广泛的应用。 拟议的研究涉及建模和方法开发，旨在开发实用的 白质和骨骼肌微观解剖特征的定量成像生物标志物， 包括1）正常、发育和异常发育的髓磷脂体积分数和髓磷脂厚度 白质，2) 肌纤维体积分数和大小，存在炎症和纤维化。这样的 生物标志物有可能通过提供定量和特异性来影响研究和临床诊断 追踪与白质发育异常相关的疾病变化的措施，例如 精神分裂症和自闭症，以及肌肉损伤和肌肉萎缩症等疾病。