Cancer Biology

癌症生物学

• 批准号: 8369385
• 负责人: MICHELE CARBONE
• 金额: $ 2.33万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8369385
• 关键词: Area; Basic Cancer Research; Basic Science; Biochemical; Biochemistry; Biological Assay; Biological Factors; Biology; Biophysics; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Etiology; Cellular biology; Chemicals; Chemoprevention; Clinic; Clinical; Collaborations; Development; Diagnosis; Diagnostic; Discipline; Early Diagnosis; Faculty; Focus Groups; Fostering; Foundations; Funding; Genetic; Goals; Hawaii; Immunobiology; Incubators; Inflammation; Intervention; Investigation; Lead; Malignant Neoplasms; Malignant neoplasm of liver; Medical center; Membrane; Mesothelioma; Modality; Molecular; Molecular Biology; Molecular Genetics; Movement; Operative Surgical Procedures; Pathology; Pathway interactions; Pharmaceutical Preparations; Pharmacy facility; Prevention; Preventive; Primary carcinoma of the liver cells; Process; Publications; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Rest; Scientist; Signal Pathway; Signal Transduction; Synthesis Chemistry; Therapeutic; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Work; base; cancer epidemiology; cancer initiation; cancer prevention; cancer therapy; clinical application; college; drug discovery; innovation; insight; medical schools; member; new therapeutic target; novel; novel diagnostics; novel therapeutics; programs; scientific organization; small molecule; tool; tumor initiation; virology

Basic research in cancer biology is paramount to unraveling and understanding the mechanisms of cancer development and progression. Novel insights obtained from basic research investigations are critical for generating new ideas and strategies for cancer prevention, diagnosis and therapy. Members of the Cancer Biology Program (CB) investigate the fundamental cellular, molecular, genetic, biochemical, and immunological mechanisms of cancer biology and develop molecular tools and experimental therapeutics that modulate them. The program has 31 actively participating members from the University of Hawaii's Cancer Center, School of Medicine, and College of Pharmacy as well as the Queen's Medical Center. Of these 25 have joined since the previous review. CB members currently receive a combined $5.63M annually in direct funding, including $3.76M from the NCI and $1.79M in other NIH support. Over the past five years, they have authored a total of 193 cancer-related publications, of which 21% originated from intraprogrammatic, 12% from inter-programmatic, and 5% from inter/intra-programmatic collaborations. The primary goal of the CB is to foster translational research through multi-disciplinary collaborations where investigations of the cellular and molecular mechanisms of cancer development and progression lead to the identification of novel therapeutic targets and potential strategies for cancer prevention, early detection, diagnosis, drug discovery and treatment. The major goals of the program are (1) to generate novel mechanistic insight into the processes that drive tumor initiation, progression, and invasion (Cancer Mechanisms); (2) to target these mechanisms with new small molecules and natural products using cellular and biochemical assays (Drug Discovery); (3) to translate these results into more effective preventive, early detection, and therapeutic modalities (Diagnostics & Intervention). Members of the program have complementary expertise in cell and molecular biology (signal transduction, membrane biophysics, immunobiology and inflammation, and genetics), virology, chemical biology (biochemistry, synthetic chemistry, natural products), pathology and surgery. In addition, the program also includes focus groups dedicated to the investigation of specific cancers. These focus groups provide a framework to translate novel research findings into the development of targeted clinical interventions or innovative diagnostic approaches in these cancers.

癌症生物学的基础研究对于解开和理解癌症发展和进展的机制至关重要。从基础研究调查中获得的新见解对于产生癌症预防，诊断和治疗的新想法和策略至关重要。癌症生物学计划（CB）的成员研究癌症生物学的基本细胞，分子，遗传，生物化学和免疫机制，并开发调节它们的分子工具和实验疗法。该计划有31名积极参与的成员，来自夏威夷大学癌症中心、医学院、药学院以及女王医疗中心。其中25个国家是自上次审查以来加入的。CB成员目前每年共获得563万美元的直接资助，其中包括来自NCI的376万美元和来自NIH其他支持的179万美元。在过去五年中，他们共撰写了193篇癌症相关出版物，其中21%来自项目内，12%来自项目间，5%来自项目间/项目内合作。 CB的主要目标是通过多学科合作促进转化研究，其中对癌症发展和进展的细胞和分子机制的研究导致识别癌症预防，早期检测，诊断，药物发现和治疗的新治疗靶点和潜在策略。该计划的主要目标是（1）产生新的机制洞察的过程，推动肿瘤的启动，发展和侵袭（癌症机制）;（2）使用细胞和生物化学测定，用新的小分子和天然产物靶向这些机制（药物发现）;（3）将这些结果转化为更有效的预防，早期发现和治疗方式（诊断和干预）。该计划的成员在细胞和分子生物学（信号转导，膜生物物理学，免疫生物学和炎症，遗传学），病毒学，化学生物学（生物化学，合成化学，天然产物），病理学和外科学方面具有互补的专业知识。此外，该计划还包括专门调查特定癌症的焦点小组。这些焦点小组提供了一个框架，将新的研究结果转化为针对这些癌症的靶向临床干预或创新诊断方法的发展。