Clinical and Translational Research Services Shared Resource

临床和转化研究服务共享资源

• 批准号: 8369400
• 负责人: MICHELE CARBONE
• 金额: $ 10.63万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8369400
• 关键词: Academic Medical Centers; Area; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Patient; Caring; Clinic; Clinical; Clinical Data; Clinical Oncology; Clinical Protocols; Clinical Research; Clinical Research Associate; Clinical Services; Clinical Trials; Commit; Communities; Community Hospitals; Community Outreach; Continuing Education; Data; Databases; Development; Devices; Diagnostic tests; Enrollment; Ensure; Environment; Family; Generations; Goals; Hawaii; Hawaiian population; Health Personnel; Individual; Information Systems; Intervention; Investigator-Initiated Research; Island; Knowledge; Left; Malignant Neoplasms; Malignant neoplasm of liver; Minority; Monitor; NCI-Designated Cancer Center; National Surgical Adjuvant Breast and Bowel Project; Nursing Research; Outcome; Pacific Island Americans; Patient Participation; Patients; Phase; Population; Postdoctoral Fellow; Process; Property; Protocols documentation; Provider; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Priority; Research Project Grants; Research Subjects; Research Training; Resource Sharing; Resources; Risk; Safety; Safety Management; Science; Services; Support System; System; Translating; Translational Research; Travel; Underrepresented Minority; United States National Institutes of Health; Universities; University Hospitals; Update; Vulnerable Populations; Work; base; bench to bedside; cancer care; cancer risk; cancer site; clinical application; cost; data management; ethnic minority population; experience; innovation; malignant breast neoplasm; oncology program; pre-clinical; prognostic; programs; sound

The primary purpose of Clinical and Translational Research Services (CTRS) is to facilitate, support, and assure the generation and conduct of high impact patient research in the most efficient and safe way possible to substantially reduce the burden of cancer for the people of Hawai'i and elsewhere. Reducing the disparate burden of cancer experienced by certain minorities and vulnerable populations is a primary goal. In the absence of a university hospital, CTRS has provided the infrastructure to give Hawai'i's community-based providers and the patients they serve access to NCI/NIH-sponsored clinical trials from Minority-based Clinical Oncology Program (MB-CCOP), National Surgical Adjuvant Breast and Bowel Project (NSABP) and research project grants. These trials have provided Hawai'i patients with access to the most promising research opportunities and contribute Hawai'i's unique multi-ethnic population to large multicenter clinical trials. Furthermore, the system maintains cancer care providers at the cutting edge of state-of-the-science care through their participation in the research and the associated continuing education activities of the system. This assures that in most cases patients can access the best care without having to leave the islands and reduces the chance of patients incurring additional costs to travel more than 2500 miles for care, or be separated from their families and social support systems while receiving cancer care. CTRS supports a level of community access and dissemination for clinical and translational research that is seldom seen at other NCI-designated cancer centers. In the absence of a university medical center, all clinical investigation is conducted through community-based providers. This gives unparalleled opportunity to accelerate the progression of discoveries from bench to bedside to community application. With the formation of the Hawai'i Cancer Consortium (HCC) this year, the University of Hawai'i Cancer Center (UHCC) will develop a vibrant clinical and translational research activity of investigator-initiated protocols. CTRS will support the development and conduct of these protocols as a first priority to rapidly translate discoveries of the UHCC's research programs into community-based clinical applications. A large component of CTRS is committed to facilitating the participation of underserved minorities in clinical trials. We have made substantial progress in this respect. Usually more than 200 new subjects each year are enrolled on cancer clinical trials of all phases, with proportional representation of Hawai'i's ethnic minorities. Native Hawaiians and other Pacific Islanders, who represent about 12% of all cancer patients and experience the worst cancer outcome, constitute 25% of patients enrolled.

临床和转化研究服务（CTRS）的主要目的是以最有效、最安全的方式促进、支持和确保高影响力患者研究的生成和进行，以大幅减轻夏威夷人民的癌症负担和其他地方。减少某些少数群体和弱势群体遭受的不同癌症负担是一个主要目标。在没有大学医院的情况下，CTRS提供了基础设施，使夏威夷的社区提供者和他们所服务的患者能够获得NCI/NIH赞助的临床试验，这些临床试验来自少数民族临床肿瘤学计划（MB-CCOP），国家外科辅助乳腺和肠道项目（NSABP）和研究项目赠款。这些试验为夏威夷患者提供了最有前途的研究机会，并为夏威夷独特的多种族人群提供了大型多中心临床试验。此外，该系统通过参与研究和系统的相关继续教育活动，使癌症护理提供者保持在科学护理的最前沿。这确保了在大多数情况下，患者可以获得最好的护理，而不必离开岛屿，并减少了患者承担额外费用的机会，旅行超过2500英里的护理，或在接受癌症护理时与家人和社会支持系统分离。CTRS支持临床和转化研究的社区访问和传播水平，这在其他NCI指定的癌症中心很少见。在没有大学医疗中心的情况下，所有临床研究都是通过社区提供者进行的。这提供了无与伦比的机会，可以加速从实验室到临床再到社区应用的研究进展。随着今年夏威夷癌症联盟（HCC）的成立，夏威夷大学癌症中心（UHCC）将开展一项充满活力的临床和转化研究活动，研究由癌症患者发起的方案。CTRS将支持这些协议的开发和实施，并将其作为首要任务，以迅速将UHCC研究计划的发现转化为基于社区的临床应用。CTRS的一大部分致力于促进服务不足的少数群体参与临床试验。我们在这方面取得了实质性进展。通常每年有200多名新受试者参加所有阶段的癌症临床试验，夏威夷少数民族的比例代表。夏威夷原住民和其他太平洋岛民约占所有癌症患者的12%，经历了最严重的癌症后果，占登记患者的25%。