Proteomics, Metabolomics and Lipidomics Core
蛋白质组学、代谢组学和脂质组学核心
基本信息
- 批准号:8234059
- 负责人:
- 金额:$ 49.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-03-01 至 2014-02-28
- 项目状态:已结题
- 来源:
- 关键词:BioinformaticsBiometryClinical TreatmentCollaborationsComputer SimulationCoupledDataDatabasesDengue VirusDiagnosticDiseaseDisease modelEbola virusFlavivirus InfectionsFlu virusFrancisellaGenerationsGenomicsHealthIndiumIndividualInfectionLabelLipidsLiquid ChromatographyMass FragmentographyMass Spectrum AnalysisMeasurementMetabolicMethodsModelingPacific NorthwestPathway interactionsPeptidesProcessProteinsProteomicsResource InformaticsResourcesSARS coronavirusSample SizeSamplingSignal TransductionStable Isotope LabelingStagingSystems BiologyTimeValidationWest Nile virusanalogbasecomparativedata acquisitiondata integrationimprovedmetabolomicsmultiple reaction monitoringprotein metabolitetherapeutic targettranscriptomics
项目摘要
The PNW RCE Proteomics, Metabolomics, and Lipidomics (PML) Core provides the resources required
for the parallel application of proteomic, metabolomic, and lipidomic analyses to diverse sample sets provide
by the RCE collaborators. The integration of data generated by these PML Core approaches with the
genomic analyses performed by individual Projects and sub-projects (Project 3 (P01) Dr. Michael Katze,
Project 4 (P01) Dr. Michael Gale, and Project 5 (R01) Dr. Fred Heffron), creates a unique opportunity to
model disease-related pathways (see Biostatistics and Bioinformatics Core) associated with infection by
severe acute respiratory syndrome (SARS) virus, flu virus, Ebola virus, West Nile virus (WNV), Dengue virus
(DENV), and Francisella novidica. The PML Core will leverage ongoing technical advances in proteomics
(including phosphoproteomics), metabolomics, lipidomics, and informatics resources available at PNNL to
generate unique suites of systems biology data by performing high throughput, sensitive, and reproducible
protein, metabolite, and lipid abundance measurements on comparative and longitudinal samples for
iterative cycles of computational modeling and experimental validation. The PML Core provides both
resources and support through multiple stages of proteomics, metabolomics, and lipidomics data acquisition,
from construction/augmentation of reference accurate mass and time tag (AMT) tag databases through
comparative quantitative analyses. Peptide and lipid coverage in AMT tag databases will be enhanced by
advanced liquid chromatography separation methods pioneered at PNNL to reduce sample complexity. In
the RCE the PML Core will leverage established and ongoing technological advancements at PNNL
accomplished under other support in order to perform the large-scale measurements demanded by the
Center collaborations.
PNW RCE蛋白质组学、代谢组学和脂质组学(PML)核心提供了所需的资源
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RICHARD D SMITH其他文献
RICHARD D SMITH的其他文献
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{{ truncateString('RICHARD D SMITH', 18)}}的其他基金
APPROACHES FOR PROTEIN MODIFICATIONS, INTERACTIONS, & SPATIAL & QUANTITATIVE DYN
蛋白质修饰、相互作用的方法,
- 批准号:
8365459 - 财政年份:2011
- 资助金额:
$ 49.7万 - 项目类别:
HIV PROTEOMIC CENTER FOR HOST-VIRAL RESPONSE CHARACTERIZATION
HIV 宿主病毒反应表征蛋白质组学中心
- 批准号:
8357610 - 财政年份:2011
- 资助金额:
$ 49.7万 - 项目类别:
HIV PROTEOMIC CENTER FOR HOST-VIRAL RESPONSE CHARACTERIZATION
HIV 宿主病毒反应表征蛋白质组学中心
- 批准号:
8172780 - 财政年份:2010
- 资助金额:
$ 49.7万 - 项目类别:
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