APPROACHES FOR PROTEIN MODIFICATIONS, INTERACTIONS, & SPATIAL & QUANTITATIVE DYN

蛋白质修饰、相互作用的方法,

基本信息

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Core 1 focuses on developments associated protein localization within the cell, the protein-protein interactions, the quantitative dynamics and protein trafficking, and the modification states of proteins applying high throughput proteomics measurements. For this annual report advancements in top-down proteomics by Center-investigators are provided; advancement in applying gas phase fractionation with FAIMS are described; measurements of posttranslational modifications including the phosphoproteome with measurements of low abundance pTyr modifications in addition to the more abundant pSer and pThr modifications; and an enhanced version of RePlay proteomics is reported. Advanced methods of sample preparation (e.g., trypsin coated nanoparticles; the biofluids CSF and saliva), pressure digestion and sonication, have been developed in support of measuring differential protein abundances for systems biology studies. Core 1 also includes the research area of activity-based proteomics (ABP and MABPP) that provides a more targeted approach to probing the sub-proteomes of tissues, cells, subcellular fractions, and biofluids. Methods in subcellular fractionation are being implemented in the Center to achieve Core 1 goals for characterizing proteins in cells and their associated localization and trafficking. Additional progress has been made on profiling the cell surface membrane proteome, sperm maturation, oncogenic virus detection, and genome annotation.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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RICHARD D SMITH其他文献

RICHARD D SMITH的其他文献

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{{ truncateString('RICHARD D SMITH', 18)}}的其他基金

Experimental Core
实验核心
  • 批准号:
    10213204
  • 财政年份:
    2018
  • 资助金额:
    $ 34.41万
  • 项目类别:
Proteomics, Metabolomics and Lipidomics
蛋白质组学、代谢组学和脂质组学
  • 批准号:
    8580047
  • 财政年份:
    2013
  • 资助金额:
    $ 34.41万
  • 项目类别:
WORKSHOP AND TRAINING ACTIVITIES
研讨会和培训活动
  • 批准号:
    8365463
  • 财政年份:
    2011
  • 资助金额:
    $ 34.41万
  • 项目类别:
HIV PROTEOMIC CENTER FOR HOST-VIRAL RESPONSE CHARACTERIZATION
HIV 宿主病毒反应表征蛋白质组学中心
  • 批准号:
    8357610
  • 财政年份:
    2011
  • 资助金额:
    $ 34.41万
  • 项目类别:
HIV PROJECT
艾滋病项目
  • 批准号:
    8365479
  • 财政年份:
    2011
  • 资助金额:
    $ 34.41万
  • 项目类别:
Proteomics, Metabolomics and Lipidomics Core
蛋白质组学、代谢组学和脂质组学核心
  • 批准号:
    8234059
  • 财政年份:
    2011
  • 资助金额:
    $ 34.41万
  • 项目类别:
HIV PROJECT
艾滋病项目
  • 批准号:
    8170720
  • 财政年份:
    2010
  • 资助金额:
    $ 34.41万
  • 项目类别:
WORKSHOP AND TRAINING ACTIVITIES
研讨会和培训活动
  • 批准号:
    8170700
  • 财政年份:
    2010
  • 资助金额:
    $ 34.41万
  • 项目类别:
HIV PROTEOMIC CENTER FOR HOST-VIRAL RESPONSE CHARACTERIZATION
HIV 宿主病毒反应表征蛋白质组学中心
  • 批准号:
    8172780
  • 财政年份:
    2010
  • 资助金额:
    $ 34.41万
  • 项目类别:
TECH R&D CORE SUPPORT FOR AIDS RESEARCH
技术研发
  • 批准号:
    8170722
  • 财政年份:
    2010
  • 资助金额:
    $ 34.41万
  • 项目类别:

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    18870435
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    1988
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    面上项目

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Increasing the Number of Highly-Qualified Biology and Mathematics Secondary Teachers in the Joliet, Illinois Area
增加伊利诺伊州乔利埃特地区高素质生物学和数学中学教师的数量
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用于结构生物学的 X 射线区域探测器系统
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    6580213
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    2003
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    $ 34.41万
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X-ray Area Detector for Structural Biology
用于结构生物学的 X 射线区域探测器
  • 批准号:
    9724191
  • 财政年份:
    1997
  • 资助金额:
    $ 34.41万
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    Standard Grant
X RAY GENERATOR/AREA DETECTOR FOR STRUCTURAL BIOLOGY
用于结构生物学的 X 射线发生器/区域探测器
  • 批准号:
    2040270
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    1997
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    $ 34.41万
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Advanced CCD-Based Synchrotron Area Detector for Structural Biology
用于结构生物学的基于 CCD 的先进同步加速器区域探测器
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    8914828
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    1990
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    6326024
  • 财政年份:
    1963
  • 资助金额:
    $ 34.41万
  • 项目类别:
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