Parental Occupational Pesticide Exposure Assessment and Childhood Leukemia Risk

描述(由申请人提供)：父母职业接触杀虫剂与儿童白血病风险的增加并不一致。以前的大多数研究都受到仅使用职称来估计农药暴露或缺乏足够的统计能力来检测关联的限制。在这项提案中，我们将在确定儿童白血病风险时，与使用基于任务的工作模块的详细工作历史信息相比，评估和量化仅使用职称导致的暴露错误分类的影响。我们将对北加州儿童白血病研究(NCCLS)的数据进行二次分析，这是一项大型病例对照研究，有超过40%的西班牙裔参与者和15%的潜在职业性农药暴露的参与父母。此外，NCCLS还包括为一部分参与者测量家中地毯灰尘中的农药浓度，这将用于识别可能因父母的职业暴露而污染家庭的农业农药。我们将确定与基于任务的工作模块相比，由职称解释的农药浓度的变异性，并评估暴露测量误差。 公共卫生相关性：儿童白血病是最常见的儿童癌症，急性淋巴细胞白血病(ALL)是最常见的亚型。父母职业接触杀虫剂被怀疑是儿童白血病的一个重要风险因素，但研究结果一直不一致，可能是由于分类错误。我们建议评估详细的基于任务的工作单元是否比仅仅是职位提供更具体的暴露估计，并量化错误分类对父母职业暴露与儿童ALL风险之间关系的影响，以帮助提供其他研究，探讨父母职业暴露对儿童各种健康结果的影响。

DESCRIPTION (provided by applicant): Parental occupational exposure to pesticides has been inconsistently associated with an increased risk of childhood leukemia. Most previous studies have been limited by the use of job titles alone to estimate pesticide exposure or lack of adequate statistical power to detect an association. In this proposal, we will evaluate and quantify the impact of exposure misclassification that results from using job titles alone compared to detailed job history information using task-based job modules, when determining the risk of childhood leukemia. We will conduct secondary analyses of data from the Northern California Childhood Leukemia Study (NCCLS), a large case-control study with more than 40% Hispanic participants and 15% of participating parents with potential occupational pesticide exposure. In addition, the NCCLS includes measurement of concentrations of pesticides in home carpet dust for a subset of participants that will be used to identify agricultural pesticides with potential for contamination of the home from parental occupational exposure. We will determine the variability of pesticide concentrations explained by job titles compared to task-based job modules, and assess exposure measurement error. PUBLIC HEALTH RELEVANCE: Childhood leukemia is the most common childhood cancer and acute lymphocytic leukemia (ALL) is the most frequent subtype. Parental occupational exposure to pesticides is suspected to be an important risk factor for childhood leukemia, but study findings have been inconsistent, likely due to misclassification errors. We propose to evaluate whether detailed task-based job modules provide more specific estimates of exposure than job titles alone, and to quantify the impact of misclassification on the associations between parental occupational exposure to pesticides and risk of childhood ALL, in order to help inform other studies examining the effect of parental occupational pesticide exposure on various health outcomes in children.