Core A: Administrative Core

拟议的新儿童环境健康中心设在加州大学伯克利分校，旨在研究宫内和早期接触家庭中潜在致癌化学品(即杀虫剂、烟草相关污染物、多氯联苯和多溴联苯醚)的影响、遗传和表观遗传因素及其在儿童白血病发展中的相互作用。拟议的中心，称为儿童白血病与环境跨学科研究中心，包括以下三个研究项目和两个核心：项目1(儿童白血病国际联合会研究)将确定与儿童白血病最相关的时间段和儿童白血病亚型的暴露，并通过汇集全球19项研究的数据，确定可以改变儿童白血病与父母吸烟或家庭农药暴露之间关系的重要基因多态性；项目2(儿童白血病暴露评估)将根据对房屋灰尘和血液样本的分析，评估致癌物暴露，特别是与烟草相关的污染物、多氯联苯和多溴二苯醚；项目3(产前暴露、DNA甲基化和儿童白血病)将利用新生儿血液更清楚地了解父母吸烟、杀虫剂、多氯联苯、多溴二苯醚暴露与儿童白血病DNA甲基化模式之间的联系。研究、翻译和社区推广核心(RTCO核心)将把每个项目的结果传播给对儿童白血病病因有共同兴趣的不同受众。核心A的主要目标是提供1)中心活动的监督、协调和整合；2)科学领导；3)集中数据管理支持。核心A将建立和管理内部和外部咨询委员会；任命两名儿科健康专家并与其合作，并在该中心的结构内支持新的初级教职员工级调查人员的研究职业发展。核心A将通过RTCO核心协调社区参与，并由足科保健专家协助

The proposed new Children's Environmental Health Center based at the University of California, Berkeley is designed to examine the effects of in utero and early life exposure to potentially carcinogenic chemicals present in homes (i.e., pesticides, tobacco-related contaminants, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs), genetic and epigenetic factors and their interplay in the development of childhood leukemia. The proposed Center, referred to as Center for Interdisciplinary Research on Childhood Leukemia and the Environment (CIRCLE) includes three Research Projects and two Cores as follows: Project 1 (Childhood Leukemia International Consortium Studies) will identify the exposures to the most relevant time periods and childhood leukemia subtypes and identify important genetic polymorphisms that can modify the association between childhood leukemia and parental tobacco smoking or home pesticide exposure by pooling data from 19 studies worldwide; Project 2 (Exposure Assessment for Childhood Leukemia) y\/ill assess carcinogen exposures, based upon analysis of house dust and blood specimens, with special interest in tobacco-related contaminants, PCBs, and PBDEs; Project 3 (Prenatal exposures, DNA Methylation, & Childhood Leukemia) will provide a clearer understanding of the association between parental smoking, pesticides, PCBs, PBDEs exposures and DNA methylation patterns in childhood leukemia, using neonatal bloods. The Research Translation and Community Outreach Core (RTCO Core) will disseminate findings from each Project to various audiences with common interest in the etiology of childhood leukemia. The main objectives of Core A are to provide 1) oversight, coordination, and integration of Center activities; 2) scientific leadership; and 3) centralized data management support. Core A will establish and manage Internal and External Advisory Committees; appoint and collaborate with two Pediatric Health Specialists, and support the research career development of new, junior faculty-level investigators within the structure of the Center. Core A will coordinate Community Engagement through the RTCO Core, assisted by the pedicatric Health Specialists