Parental Occupational Pesticide Exposure Assessment and Childhood Leukemia Risk

父母职业农药暴露评估和儿童白血病风险

• 批准号: 8330805
• 负责人: Catherine Metayer
• 金额: $ 3.45万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-09 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8330805
• 关键词: Acute Lymphocytic Leukemia; Agriculture; California; Carpet; Case-Control Studies; Child; Childhood Acute Lymphocytic Leukemia; Childhood Leukemia; Concentration measurement; Data; Data Analyses; Data Collection; Disease; Dust; Epidemiologic Studies; Epidemiology; Exposure to; Funding; Goals; Grant; Health; Hispanics; Home environment; Incidence; Linear Regressions; Malignant Childhood Neoplasm; Measurement; Measures; Methods; Modeling; Not Hispanic or Latino; Occupational; Occupational Exposure; Occupations; Outcome; Parents; Participant; Pesticides; Recording of previous events; Relative (related person); Research Design; Risk; Risk Estimate; Risk Factors; Time; attenuation; base; cancer epidemiology; disorder risk; epidemiologic data; improved; leukemia; pesticide exposure; predictive modeling; programs; residence; response; validation studies

DESCRIPTION (provided by applicant): Parental occupational exposure to pesticides has been inconsistently associated with an increased risk of childhood leukemia. Most previous studies have been limited by the use of job titles alone to estimate pesticide exposure or lack of adequate statistical power to detect an association. In this proposal, we will evaluate and quantify the impact of exposure misclassification that results from using job titles alone compared to detailed job history information using task-based job modules, when determining the risk of childhood leukemia. We will conduct secondary analyses of data from the Northern California Childhood Leukemia Study (NCCLS), a large case-control study with more than 40% Hispanic participants and 15% of participating parents with potential occupational pesticide exposure. In addition, the NCCLS includes measurement of concentrations of pesticides in home carpet dust for a subset of participants that will be used to identify agricultural pesticides with potential for contamination of the home from parental occupational exposure. We will determine the variability of pesticide concentrations explained by job titles compared to task-based job modules, and assess exposure measurement error.

描述（由申请人提供）：父母职业接触杀虫剂与儿童白血病风险增加的关系并不一致。大多数先前的研究都受到限制，仅使用职位头衔来估计农药暴露或缺乏足够的统计能力来检测关联。在本提案中，我们将评估和量化在确定儿童白血病风险时，仅使用职位与使用基于任务的工作模块的详细工作历史信息相比导致的暴露错误分类的影响。我们将对北加州儿童白血病研究（NCCLS）的数据进行二次分析，这是一项大型病例对照研究，超过40%的西班牙裔参与者和15%的参与父母有潜在的职业农药暴露。此外，NCCLS还包括对一部分参与者的家庭地毯灰尘中农药浓度的测量，这些浓度将用于识别父母职业接触可能对家庭造成污染的农业农药。与基于任务的工作模块相比，我们将确定由职称解释的农药浓度的可变性，并评估暴露测量误差。