Biorepository & Tissue Research Facility

生物样本库

• 批准号: 8231138
• 负责人: MICHAEL J. WEBER
• 金额: $ 9.39万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8231138
• 关键词: Advanced Malignant Neoplasm; Anatomy; Animal Model; Basic Science; Biological Markers; Blood; Cancer Center Support Grant; Cells; Clinical; Clinical Research; Clinical Trials; Complex; Diagnostic tests; Disease; Histology; Histopathology; Human; Immunohistochemistry; Knowledge; Lasers; Leadership; Malignant Neoplasms; Microdissection; Operative Surgical Procedures; Pathologist; Pathology; Phase; Protein Microchips; Research; Research Personnel; Resource Sharing; Scanning; Services; Slide; Specimen; Techniques; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Universities; Urine; Validation; Virginia; anticancer research; base; biobank; cancer diagnosis; cancer therapy; clinical practice; digital; human tissue; insight; novel diagnostics; outcome forecast; research facility; tool

Since the last renewal, the previous Tissue Procurement Facility and Research Histology Shared Resource have merged and expanded their functions to form the Biorepository and Tissue Research Facility (BTRF), under new leadership. The BTRF makes human biospecimens available for basic, translational, and clinical research. It is the major conduit through which human tissue specimens are transferred from the Pathology, Surgery and other clinical departments to research labs at the University of Virginia (UVA), and is the major processor of human biospecimens (tissue, blood, urine) in support of clinical trials at UVA. In addition, this is the only shared research facility that supports standard histology services and complex histology-based analytic techniques for animal models and human tissues, including tissue microarray construction, laser microdissection, immunohistochemistry, digital slide scanning and reverse-phase protein microarrays. Expert histopathology support from Board-certified Anatomic Pathologists is provided for these activities through this Shared Resource. The biorepository and analytic services are often vertically integrated with each other to allow for "one-stop shopping" for investigators carrying out translational or clinical cancer research. BTRF services make possible new insights into cancer disease mechanisms by the analysis of tissues and biofluids, assist in the discovery and validation of new clinical cancer biomarkers, and support clinical trials of novel diagnostic tests and therapies for cancer.

自上次更新以来，之前的组织采购机构和研究组织学共享资源 合并并扩大其职能，形成生物储存和组织研究设施（BTRF）， 在新的领导下BTRF使人类生物标本可用于基础，翻译和临床 research.它是人体组织标本从病理室转移的主要渠道， 外科和其他临床部门的研究实验室在弗吉尼亚大学（UVA），是主要的 人类生物标本（组织、血液、尿液）的处理器，以支持UVA的临床试验。此外，这是 唯一的共享研究设施，支持标准的组织学服务和复杂的组织学为基础的 用于动物模型和人体组织的分析技术，包括组织微阵列构建、激光 显微切割、免疫组织化学、数字载玻片扫描和反相蛋白质微阵列。专家 委员会认证的解剖病理学家为这些活动提供组织病理学支持， 这个共享资源。生物储存库和分析服务通常相互垂直整合 为进行转化或临床癌症研究的研究人员提供“一站式服务”。BTRF 服务通过组织分析，使癌症疾病机制的新见解成为可能， 生物流体，协助发现和验证新的临床癌症生物标志物，并支持临床试验， 癌症的新诊断测试和疗法。